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Stoffwechsel von 17α-Hydroxyprogesteron in der Nebennierenrinde, im Phäochromocytom und im Paragangliom des Menschen

  • G. S. Rao
  • M. L. Rao
  • H. Breuer
Part of the Symposion der Deutschen Gesellschaft für Endokrinologie in Ulm vom 26.—28. Februar 1970 book series (ENDOKRINOLOGIE, volume 16)

Metabolism of 17α-Hydroxyprogesterone in Normal Adrenal Cortex, Pheochromocytoma and Paraganglioma

Summary

Radioactive 17α-hydroxyprogesterone vas incubated with slices of normal adrenals, and of pheochromocytoma and paraganglioma tumours. The metabolites vere separated and purified by chromatography in different systems; their radiochemical purity vas proved by crystallization to constant specific activity. Cortisol, cortisone. Compound S and testosterone vere identified as metabolites from all three tissues. The formation of these metabolites was significantly lover in the tumour tissues. The study demonstrates that not only the pheochromocytoma, but also the extra-adrenal tumour, paraganglioma, contains enzyme systems capable of synthesizing steroid hormones.

Literatur

  1. 1.
    Manger, W. M.: Hormones and Hypertension, p. 21. Springfield: Charles C. Thomas 1966.Google Scholar
  2. 2.
    Mulrow, P. J., Cohen, G. L., Yesner, R.: Yale J. Biol. Med. 31, 363 (1959).PubMedGoogle Scholar
  3. 3.
    Carballeira, A., Venning, E. H.: Steroids, 4, 329 (1964).CrossRefGoogle Scholar
  4. 4.
    Acevedo, H. F., Beering, S. C.: Steroids, 6, 531 (1965).PubMedCrossRefGoogle Scholar
  5. 5.
    Kokai, K. , Fazekas, A. G., Kovacs, K. : Acta med. Acad. Sci. hung. 25 107 (1968).PubMedGoogle Scholar
  6. 6.
    Fazekas, A. G., Kokai, K.: Steroids, 9, 177 (1967).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 1970

Authors and Affiliations

  • G. S. Rao
    • 1
  • M. L. Rao
    • 1
  • H. Breuer
    • 1
  1. 1.Institut für Klinische Biochemie und Klinische ChemieUniversität BonnDeutschland

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