Involvement of Ocular Opiate Receptors in the Regulation of Intraocular Pressure
Receptors for morphine and endogenous morphine-like peptides (opiate receptors) have largely been described in nervous structures both central and peripheral (for a review, see: Olson et al. 1981). Recently, the presence of opiate receptors has also been suggested in the iris of rabbit (Drago et al. 1980) and of man (Fanciullacci et al. 1980). In fact, the intraocular injection of morphine and D-Ala2-metenkephalinamide (D-Ala-E, a synthetic opioid peptide resistant to enzymatic degradation) induced a significant dose-dependent decrease in pupillary size in conscious rabbits (Drago et al. 1980). Moreover, pupillary constriction following the instillation of morphine has been described in man (Nomof et al. 1968; Fanciullacci et al. 1979, 1980).
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- Fanciullacci M, Boccuni M, Ermini P (1979) Recettori morfinici nell’iride umana. IV Congr Soc Ital Farmacol Clin, Firenze, Abs 16Google Scholar