Vaccination Against Pathogenic Cells by DNA Inoculation
- 108 Downloads
The goal of vaccination is to induce immunity to protect the host from disease. Vaccines should generate long-term protective immune responses which perform immune surveillance against specific antigens. Currently, a wide spectrum of vaccines are under development against not only infectious diseases, but also against cancers as well as allergic and autoimmune diseases. The mechanisms by which vaccines elicit protective immune responses against tumor growth have not been completely understood. Costimulatory molecule activation and strong cytolytic T cells (CTLs) have been implicated in the control of tumor cell growth or metastasis. Specific monoclonal antibodies have been also shown to control tumor cell growth to some degree. To achieve protective immune responses against tumor cells, we need to understand the context of the different cellular, humoral and molecular functions of the immune system.
KeywordsRabies Virus Antitumor Immunity Protective Immune Response Pathogenic Cell Gene Inoculation
Unable to display preview. Download preview PDF.
- Agadjanyan MG, Wang B, Ugen KE, Villafana T, Merva M, Petrushina I, Williams WV and Weiner DB (1994) DNA inoculation with an HTLV-I envelope construct elicits immune responses in rabbits. Vaccines 94:47–53Google Scholar
- Dranofï G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D and Mulligan RC (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long lasting antitumor immunity (Meeting abstract). Gene Therapy for Neoplastic Diseases June 26–29, 1993, Washington, DC, AGoogle Scholar
- Guo HG, Veronese F, Tschachler E, Pal R, Gallo RC and Reitz MS (1989) Characterization of an HIV-1 point mutation blocked in envelope glycoprotein cleavage. V. International conference on AIDSGoogle Scholar
- Lafreniere R and Rosenberg SA (1985a) Adoptive immunotherapy of murine hepatic metastases with lymphokine activated killer (LAK) cells and recombinant interleukin 2 (RIL 2) can mediate the regression of both immunogenic and nonimmunogenic sarcomas and an adenocarcinoma. J Immunol 135:4273–80PubMedGoogle Scholar
- Morton DL, Foshag LJ, Hoon DS, Nizze JA, Famatiga E, Wanek LA, Chang C, Davtyan DG, Gupta RK, Elashoff R and Irie RF (1992) Prolongation of survival in metastatic melanoma after active specific immunotherapy with a new polyvalent melanoma vaccine [published erratum appears in Ann Surg 1993 Mar; 217(3): 309]. Ann Surg 216:463–82PubMedCrossRefGoogle Scholar
- Robinson HL, Fynan EF and Webster RG (1993) Use of direct DNA inoculations to elicit protective immune responses. Vaccines 93 Cold Spring Harbor Press:311–315Google Scholar
- Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Feigner PL, Dwarki VJ, Gromkowski SH, Deck RR, DeWitt CM, Friedman A, Hawe LA, Leander KR, Martinez D, Perry HC, Shiver JW, Montgomery DL and Liu M (1993) Heterologous protection against Influenza by injection of DNA encoding a viral protein. Science 259:1745–1749PubMedCrossRefGoogle Scholar
- Wang B, Boyer J, Srikantan V, Coney L, Carrano R, Phan C, Merva M, Dang K, Agadjanyan M, Gilbert L, Ugen K, Williams VW and Weiner DB (1993) DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and nonhuman primates. DNA Cell Biol 12:799–805PubMedCrossRefGoogle Scholar