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Orthopädische Hämophiliebehandlung pp 27–33Cite as

Tissue Factor Pathway Inhibitor (TFPI): Nachweis und Bestimmung in der Synovialflüssigkeit großer Gelenke

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Zusammenfassung

Tissue Factor Pathway Inhibitor (TFPI) und Antithrombin sind natürliche Hemmstoffe von Faktor Xa und TF/Faktor-VIIa-Komplex. Dabei kommt es zur Hemmung des Faktors Xa und im nächsten Schritt im Komplex mit diesem, zur Inhibiton des aktivierten Faktors VII. So ist TFPI zusammen mit Faktor Xa, VIIa und Thromboplastin (= „tissue factor“) endogener Inhibitor der extrinsischen Gerinnungskaskade und verlängert im Plasma die Gerinnungszeit.

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Authors
  1. S. Müller
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  2. R. Schulz
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  3. I. Scharrer
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  4. L. Hovy
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Editor information

Editors and Affiliations

  1. Innere Medizin, Universitätsklinik Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany

    I. Scharrer

  2. Friedrichsheim, Orthopädische Universitätsklinik, Marienburgstr. 2, 60528, Frankfurt, Germany

    L. Hovy

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© 1998 Springer-Verlag Berlin Heidelberg

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Müller, S., Schulz, R., Scharrer, I., Hovy, L. (1998). Tissue Factor Pathway Inhibitor (TFPI): Nachweis und Bestimmung in der Synovialflüssigkeit großer Gelenke. In: Scharrer, I., Hovy, L. (eds) Orthopädische Hämophiliebehandlung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80468-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-80468-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63365-5

  • Online ISBN: 978-3-642-80468-7

  • eBook Packages: Springer Book Archive

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