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Tissue Factor Pathway Inhibitor (TFPI): Nachweis und Bestimmung in der Synovialflüssigkeit großer Gelenke

  • S. Müller
  • R. Schulz
  • I. Scharrer
  • L. Hovy
Conference paper

Zusammenfassung

Tissue Factor Pathway Inhibitor (TFPI) und Antithrombin sind natürliche Hemmstoffe von Faktor Xa und TF/Faktor-VIIa-Komplex. Dabei kommt es zur Hemmung des Faktors Xa und im nächsten Schritt im Komplex mit diesem, zur Inhibiton des aktivierten Faktors VII. So ist TFPI zusammen mit Faktor Xa, VIIa und Thromboplastin (= „tissue factor“) endogener Inhibitor der extrinsischen Gerinnungskaskade und verlängert im Plasma die Gerinnungszeit.

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Literatur

  1. 1.
    Abumiya T, Nakamura S, Takenaka A et al. (1994) Response of plasma tissue factor pathway inhibitor to diet-induced hypercholesterolemia in crab-eating monkeys. Atherioscler Thromb 14 /3: 483–488CrossRefGoogle Scholar
  2. 2.
    Airens RAS, Coppola R, Potenza I, Mannucci PM (1995) The increase with age of the components of the tissue factor coagulation pathway is gender-dependent. Blood Coag Fibrinol 6: 388–394CrossRefGoogle Scholar
  3. 3.
    Brinkmann T, Kähnert H, Prohaska W, Nordfang O, Kleesiek K (1994) Synthesis of tissue factor pathway inhibitor in human synovial cells and chondrocytes Makes joints the predilected site of bleeding in haemophiliacs. Eur J Clin Chem Clin Biochem 32: 313–317PubMedGoogle Scholar
  4. 4.
    Broze GJ, Girard TJ, Novotny WF (1990) Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochemistry 29: 7539–7546PubMedCrossRefGoogle Scholar
  5. 5.
    Chitolie A, Hudson M, Wakefield AJ, Riddell A, Lee CA, Pounder RE (1993) Tissue factor pathway inhibitor (TFPI) and factor VII in inflammatory bowel disease (IBD). Thromb Haemostas THHADQ 69 /6: 1081Google Scholar
  6. 6.
    Erhardtsen E, Ezban M, Madsen MT et al. (1995) Blocking of tissue factor pathway inhibitor ( TFPI) shortens bleeding time in rabbits with antibody induced haemo¬philia A. Blood Coag Fibrinol 6: 388–394Google Scholar
  7. 7.
    Fareed J, Callas DD, Hoppensteadt D, Bernes EW Tissue (1995) Factor antigen levels in various biological fluids. Blood Coag Fibrinol 6/1: S 32–S 36Google Scholar
  8. 8.
    Hansen JB, Huseby NE, Sandset PM et al. (1994) Tissue factor pathway inhibitor and lipoproteins. Evidence for association with and regulation by LDL in human plasma. Atherioscler Thromb 14 /2: 223–229CrossRefGoogle Scholar
  9. 9.
    Hedner U (1990) Factor Vila in the treatment of hemophilia. Blood Coag Fibrinol 1: 307–317CrossRefGoogle Scholar
  10. 10.
    Imubind Total TFPI ELISA Kit, Product #849. American Diagnostica Inc. ADI, 94- 06–22Google Scholar
  11. 11.
    Kalbas M, Hinz,U, Müller-Berghaus G (1993) Heparin-induced release of tissue factor pathway inhibitor (TFPI) by human endothelial and malignant cells. Thromb Haemostas THHADQ 69 /6: 681Google Scholar
  12. 12.
    Mesters RM, Kienast J, Ostermann H, Loo J van de (1993) Tissue factor pathway inhibitor (TFPI) in septicemia: a prospective study in neutropenic patients. Thromb Haemostas THHADQ 69 /6: 1198Google Scholar
  13. 13.
    Sandset PM, Larsen ML, Abildgaard U, Lindahl AK, Odegaard OR (1991) Chromogenic substrate assay of extrinsic pathway inhibitor (EPI): Levels in the normal population and relation to cholesterol. Blood Coag Fibrinol 2: 425–433Google Scholar
  14. 14.
    Wendisch J, Weissbach G, Harenberg J (1993) The behaviour of the tissue factor pathway inhibitor (TFPI) in healthy and sick children. Thromb Haemostas THHADQ 69 /6: 682Google Scholar
  15. 15.
    Zitou D, Bara L, Basdevant A, Guy-Grand B, Samama M (1993) Human hyperglyce- ridemia is associated with an increase of F VII coagulant activity and a decrease of TFPI activity. Thromb Haemostas THHADQ 69 /6: 561Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • S. Müller
  • R. Schulz
  • I. Scharrer
  • L. Hovy

There are no affiliations available

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