The Function of Modulators in Proteasome MHC Class I Antigen Processing Activity

  • P.-M. Kloetzel
Conference paper


In eukaryotes the major non-lysosmal proteolytic system is characterized by a high-molecular-mass ATP-dependent 26S protease (for review see Coux et al. 1996). This complex is composed of the 20S proteasome, forming the proteolytic core, and the 19S regulator PA700, rendering ATP dependence and binding sites for ubiquitinated protein substrates (Rivett 1993; Hochstrasser 1995). The essential 26S enzyme complex is, in collaboration with the ubiquitin signalling pathway, responsible for the selective turnover of cytosolic and nuclear proteins.


Proteasome Complex Fluorogenic Peptide Substrate Multicatalytic Proteinase Proteasome Regulator Multicatalytic Proteinase Complex 
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© Springer-Verlag Berlin Heidelberg 1998

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  • P.-M. Kloetzel

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