DNA Vaccines for Infectious Diseases, Allergies and Cancer

  • R. G. Whalen


DNA vaccination involves the direct injection of a suitable designed plasmid DNA molecule into a tissue such that the antigenic proteins encoded by the plasmid are expressed in the cells of the treated host. This extraordinarily simple approach has been translated into practice for many antigens from infectious agents, for putative tumor antigens, and for certain potential allergens. If the results currently obtained in animal models can be replicated with equal efficiency in humans and large animals, and if the justifiable concerns about safety can be resolved, then the DNA vaccination may become the basis for an entirely new generation of vaccines.


Infectious Hematopoietic Necrosis Virus Genetic Immunization Putative Tumor Antigen 
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© Springer-Verlag Berlin Heidelberg 1998

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  • R. G. Whalen

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