DNA Vaccines for Infectious Diseases, Allergies and Cancer
DNA vaccination involves the direct injection of a suitable designed plasmid DNA molecule into a tissue such that the antigenic proteins encoded by the plasmid are expressed in the cells of the treated host. This extraordinarily simple approach has been translated into practice for many antigens from infectious agents, for putative tumor antigens, and for certain potential allergens. If the results currently obtained in animal models can be replicated with equal efficiency in humans and large animals, and if the justifiable concerns about safety can be resolved, then the DNA vaccination may become the basis for an entirely new generation of vaccines.
KeywordsInfectious Hematopoietic Necrosis Virus Genetic Immunization Putative Tumor Antigen
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- Angus CW, Klivington D, Wyman J, Kovacs JA (1996) Nucleic acid vaccination against Toxoplasma gondii in mice. J Eukaryot Microbiol 43:117SGoogle Scholar
- Boyer JD, Ugen KE, Wang B, Agadjanyan M, Gilbert L, Bagarazzi ML, Chattergoon M, Frost P, Javadian A, Williams WV, Refaeli Y, Ciccarelli RB, McCallus D, Coney L, Weiner DB (1997) Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat Med 3:526–532PubMedCrossRefGoogle Scholar
- Davis HL, Michel ML, Mancini M, Schleef M, Whalen RG (1994) Long-lasting production of antibody to hepatitis B surface antigen after genetic vaccination with pure plasmid DNA expression vectors. In: Eighth Cent-Gardes Colloquium, Mérieux Foundation, Paris, pp. 329–334Google Scholar
- Davis HL, Michel ML, Mancini M, Schleef M, Whalen RG (1995) DNA-based immunization overcomes H-2 haplotype-restricted nonresponsiveness to HBsAg in mice. In: Chanock RM, Brown F, Ginsberg HS, Norrby E (eds) Vaccines ‘95. Cold Spring Harbor Press, New York, pp 111–116Google Scholar
- González Armas JC, Morello CS, Cranmer LD, Spector DH (1996) DNA immunization confers protection against murine cytomegalovirus infection. J Virol 70:7921–7928Google Scholar
- Inchauspé G, Vitvitski L, Major ME, Jung G, Spengler U, Maisonnas M, Trépo C (1997) Plasmid DNA expressing a secreted or a nonsecreted form of hepatitis C virus nucleocapsid: comparative studies of antibody and T-helper responses following genetic immunization. DNA Cell Biol 16:185–195PubMedCrossRefGoogle Scholar
- Leclerc C, Dériaud E, Rojas M, Whalen RG (1997) The preferential induction of a Th1 immune response by DNA-based immunization is mediated by the immunostimulatory effect of plasmid DNA. Cell Immunol (in press)Google Scholar
- Prince AM, Whalen RG, Brotman B (1997) Successful nucleic acid based immunization of newborn chimpanzees against HBV. Vaccine (in press)Google Scholar
- Tsuji T, Hamajima K, Ishii N, Aoki I, Fukushima J, Xin KQ, Kawamoto S, Sasaki S, Matsunaga K, Ishigatsubo Y, Tani K, Okubo T, Okuda K (1997b) Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen. Eur J Immunol 27:782–787PubMedCrossRefGoogle Scholar
- Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L (1996) Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med 2:899–905PubMedCrossRefGoogle Scholar