Origin of Peptides Presented by MHC Class I Molecules: Generation by Proteasomes Precedes Evolution of the Immune System
Major histocompatibility complex (MHC) class I molecules present peptide epitopes, derived from cytosolic and nuclear proteins, for recognition by CD8+ T cells. The vast majority of these epitopes are derived from self-proteins and are recognized primarily by the precursors of CD8+ T cells within the thymus, in order to delete those that are self-reactive. A small proportion of MHC class I epitopes, derived from proteins of intracellular pathogens or from mutated tumor-associated self-proteins, are recognized by peripheral CD8 + T cells, which are then activated to cytotoxic cells and destroy the cells presenting these epitopes.
KeywordsMajor Histocompatibility Complex Transporter Associate With Antigen Processing Proteolytic Fragment Peptide Binding Groove Major Histocompatibility Complex Complex
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