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Molecular Pathogenesis of Urinary Tract Infections

  • Chapter
Bacterial Infection: Close Encounters at the Host Pathogen Interface

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 225))

Abstract

Urinary tract infection (UTI) is the most common bacterial infection of the human body. It has been estimated that there are as many as 8 million visits a year to physicians’ offices for treatment of the symptoms of UTI and more than 100 000 hospital admissions for serious infections (US Department of Health and Human Services 1990). In addition, the urinary tract is usually the most common source of bacteremia in hospitals and nursing homes. The presence of bacteria in urine (bacteriuria) alone is not necessarily indicative of a UTI; significant bacterial counts (> 105 cfu/ml) and pyuria are the classic signs of UTI. Infections can range from mild, asymptomatic episodes of bladder infection (cystitis) to more severe, life-threatening complications of the kidney, such as acute pyelonephritis.

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Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA, 02115, USA

    S. E. F. D’Orazio

  2. Department of Microbiology and Immunology, University of Miami School of Medicine, P.O. Box 016960 (R-138), Miami, FL, 33101, USA

    C. M. Collins

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  1. S. E. F. D’Orazio
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  2. C. M. Collins
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  1. Division of Oncovirology, BCC 239, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Peter K. Vogt Ph.D.

  2. Department of Molecular, Cellular, and Developmental Biology, University of California, 93106, Santa Barbara, CA, USA

    Michael J. Mahan Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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D’Orazio, S.E.F., Collins, C.M. (1998). Molecular Pathogenesis of Urinary Tract Infections. In: Vogt, P.K., Mahan, M.J. (eds) Bacterial Infection: Close Encounters at the Host Pathogen Interface. Current Topics in Microbiology and Immunology, vol 225. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80451-9_8

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  • DOI: https://doi.org/10.1007/978-3-642-80451-9_8

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