Fe(III) Periplasm-to-Cytosol Transporters of Gram-Negative Pathogens

  • T. A. Mietzner
  • S. B. Tencza
  • P. Adhikari
  • K. G. Vaughan
  • A. J. Nowalk
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 225)


Iron acquisition by bacteria is a concept that is embedded in both classical microbiology and contemporary biochemistry. Early work by Warburg (1949) defined the bacterial requirement for iron and allowed Schade and Caroline (Schade 1985) to deduce that the bacteriostatic property of serum could be reversed by the inclusion of iron. This in turn led to the contributions of Neilands and colleagues (1987) toward defining the biology of bacterial, fungal, and plant siderophores; this is a concept that is now accepted as a necessary, but by itself insufficient contributor to the virulence of many bacterial pathogens (Weinberg 1978, 1984). Focused studies on bacterial iron acquisition have set up a dichotomy of iron transport systems for gram-negative pathogens: those that employ a siderophore-mediated mechanism (Neilands 1980, 1981, 1991, 1995; Sawatzki 1987) and those that utilize a mechanism involving transferrin-bound iron (Schryvers and Lee 1989; Williams and Griffiths 1992). The culmination of these studies is a broad literature describing the molecular and biochemical basis for high-affinity iron transport.


Neisseria Gonorrhoeae Iron Transport Iron Acquisition Human Transferrin Human Lactoferrin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • T. A. Mietzner
    • 1
  • S. B. Tencza
    • 1
  • P. Adhikari
    • 1
  • K. G. Vaughan
    • 1
  • A. J. Nowalk
    • 1
  1. 1.Department of Molecular Genetics and BiochemistryUniversity of Pittsburgh School of MedicinePittsburghUSA

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