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Bacterial Infection: Close Encounters at the Host Pathogen Interface pp 13–35Cite as

Anthrax Pathogenesis and Host Response

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Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 225)

Abstract

Anthrax has been both a scourge and a fundamental model for infectious disease studies for over a century. Death associated with systemic anthrax is mimicked in animals challenged with anthrax lethal toxin, a virulence factor believed to affect only macrophages. Animals depleted of macrophages become resistant to the toxin, while reintroduction of cultured macrophages into depleted animals restores sensitivity. These studies and others implicate an active role for the innate immune system in the demise of the anthrax victim. Many of the molecular factors and events in the cascade of lethal events during anthrax infections have now been identified. Other recent overviews of anthrax pathogenesis and toxins include those by Stephen (1986), Friedlander (1990), Leppla (1995), and Hanna and Collier (1997).

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  1. Department of Microbiology, Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    P. Hanna

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  1. Division of Oncovirology, BCC 239, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Peter K. Vogt Ph.D.

  2. Department of Molecular, Cellular, and Developmental Biology, University of California, 93106, Santa Barbara, CA, USA

    Michael J. Mahan Ph.D.

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Hanna, P. (1998). Anthrax Pathogenesis and Host Response. In: Vogt, P.K., Mahan, M.J. (eds) Bacterial Infection: Close Encounters at the Host Pathogen Interface. Current Topics in Microbiology and Immunology, vol 225. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80451-9_2

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