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Diffusion Imaging with Echo-Planar Imaging

  • R. Turner

Abstract

By diffusion we mean the random, thermally activated motion of particles from site to site, often given the name of Brownian motion, after its first observer. This may be self-diffusion, as in the case of a pure liquid in which we may conceptually label one of the molecules and follow its motion over the course of time, or diffusion of one type of particle among others, such as the movement of hydrogen atoms through certain types of metal, the movement of small dust particles through still water, or the diffusion of water molecules through cell membranes. In solids self-diffusion is extremely slow because the energy barriers separating atomic sites are considerably greater than the thermal energy available, 3kT/2 per molecule.

Keywords

Apparent Diffusion Coefficient Magn Reson Image Free Induction Decay Diffusion Gradient Diffusion Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Le Bihan D, Breton E (1985) Imagerie de diffusion in-vivo par resonance magnétique. CR Acad Sci [II] 15:1109–1112Google Scholar
  2. 2.
    Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologie disorders. Radiology 161:401–407PubMedGoogle Scholar
  3. 3.
    Jost W (1960) Diffusion in solids, liquids, gases. Academic, New YorkGoogle Scholar
  4. 4.
    Hazlewood CF, Rorschach HE, Lin C (1991) Diffusion of water in tissues and MRI. Magn Reson Med 19:214–216PubMedCrossRefGoogle Scholar
  5. 5.
    Stejskal EO, Tanner JE (1964) Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 42:288–292CrossRefGoogle Scholar
  6. 6.
    Corey DG, Garroway AN (1990) Measurement of translational displacement probabilities by NMR: an indicator of compartmentation. Magn Reson Med 14:435–444CrossRefGoogle Scholar
  7. 7.
    Von Meerwall E, Ferguson RD (1981) Interpreting pulsed-gradient spin-echo diffusion experiments with permeable membranes. J Chem Phys 74:6956–6959CrossRefGoogle Scholar
  8. 8.
    Taylor DG, Bushell MC (1985) The spatial mapping of translational diffusion coefficients by the NMR imaging technique. Phys Med Biol 30:345–349PubMedCrossRefGoogle Scholar
  9. 9.
    Le Bihan D, Turner R, Moonen CTW, Pekar J (1991) Imaging of diffusion and microcirculation with gradient sensitization: design, strategy and significance. J Magn Reson Imaging 1:7–28PubMedCrossRefGoogle Scholar
  10. 10.
    Merboldt KD, Bruhn H, Frahm J, Gyngell ML, Hänicke W, Diemling M (1989) MRI of ‘diffusion’ in the human brain: new results using a modified CE-FAST sequence. Magn Reson Med 9:423–429PubMedCrossRefGoogle Scholar
  11. 11.
    Chenevert TL, Brunberg JA, Schielke GP (1989) Quantitative improvement of in vivo tissue perfusion and diffusion imaging. In: Book of abstracts: Society of Magnetic Resonance in Medicine 1989. Berkeley, Society of Magnetic Resonance in Medicine, 1989, p 62Google Scholar
  12. 12.
    Poncelet B, Wedeen VJ, Cohen MS, Weisskoff RM, Brady TJ (1991) Brain motion measurement with EPI. In: Book of abstracts, Society of Magnetic Resonance in Medicine 1991. Berkeley: Society of Magnetic Resonance in Medicine, 1991, p 855Google Scholar
  13. 13.
    Deimling M, Mueller E, Laub G (1990) Diffusion weighted imaging with turbo-FLASH. In: Book of abstracts: Society of Magnetic Resonance in Medicine 1990. Berkeley: Society of Magnetic Resonance in Medicine. 1990, p 387Google Scholar
  14. 14.
    Turner R (1988) Perfusion studies and fast imaging. In: Rescigno A, Boicelli A (eds) Cerebral blood flow. Plenum, New York, pp 245–258Google Scholar
  15. 15.
    Mansfield P (1977) Multi-planar image formation using NMR spin echoes. J Phys C 10:L55–L58CrossRefGoogle Scholar
  16. 16.
    Avram HE, Crooks LE (1988) Effect of self-diffusion on echo-planar imaging. In: Book of abstracts: Society of Magnetic Resonance in Medicine 1988. Berkeley: Society of Magnetic Resonance in Medicine, 1988, p 980Google Scholar
  17. 17a.
    Turner R, Maier J, Vavrek R, Le Bihan D (1989) EPI diffusion imaging of the brain at 1.5 tesla without motion artifact using a localized head gradient coil. In: Book of abstracts: Society of Magnetic Resonance in Medicine 1989. Berkeley: Society of Magnetic Resonance in Medicine, 1989, WIP, p 1123Google Scholar
  18. 17b.
    Turner R, Le Bihan D, Maier J, Vavrek R, Hedges LK, Pekar J (1990) Echo-planar imaging of intra-voxel incoherent motion. Radiology 177:407–414PubMedGoogle Scholar
  19. 18.
    Warach S, Wielopolski P, Edelman RR (1993) Identification and characterization of the ischemic penumbra of acute human stroke using echo-planar diffusion and perfusion imaging. In: Book of abstracts, Society of Magnetic Resonance in Medicine 1993. Berkeley, Society of Magnetic Resonance in Medicine, 1993, p 249Google Scholar
  20. 19.
    Turner R (1989) Single shot imaging at 4.7 tesla. Relaxation times, GE NMR Instrum. Newslett 6:4–6Google Scholar
  21. 20.
    Turner R, Le Bihan D (1990) Single-shot diffusion imaging at 2.0 tesla. J Magn Reson 86:445–452CrossRefGoogle Scholar
  22. 21.
    McKinstry RC, Weisskopf RM, Cohen MS, Vevea JM, Kwong KK, Rzedzian RR, Brady TJ, Rosen BR (1990) Diffusion-weighted Imaging of the Brain using EPI. In: Book of abstracts: Society for Magnetic Resonance Imaging, WIP, p 5Google Scholar
  23. 22.
    Howseman AM, Stehling MK, Chapman B, Coxon R, Turner R, Ordidge RJ, Cawley MG, Glover P, Mansfield P, Coupland RE (1988) Improvements in snapshot nuclear magnetic resonance imaging. Br J Radiol 61:822–828PubMedCrossRefGoogle Scholar
  24. 23.
    Wong EC, Bandettini PA, Hyde JS (1992) Echo-planar imaging of the human brain using a three axis local gradient coil. In: Book of abstracts, Society of Magnetic Resonance in Medicine 1992. Berkeley, Society of Magnetic Resonance in Medicine, 1992, p 105Google Scholar
  25. 24.
    Turner R (1986) A target field approach for optimal coil design. J Phys D 19:L147–L151CrossRefGoogle Scholar
  26. 25.
    Turner R (1988) Minimum inductance coils. J Phys E 21:948–952CrossRefGoogle Scholar
  27. 26.
    Wong EC, Jesmanowicz A, Hyde JS (1991) Coil optimization for MRI by conjugate gradient descent. Magn Reson Med 21:39–48PubMedCrossRefGoogle Scholar
  28. 27.
    Turner R (1993) Gradient coil design: a review of methods. Magn Reson Imaging 11:903–20PubMedCrossRefGoogle Scholar
  29. 28.
    Moseley ME, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J, Wendland MF, Weinstein PR (1990) Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med 14:330–346PubMedCrossRefGoogle Scholar
  30. 29.
    Chenevert TL, Brunberg JA, Pipe JG (1990) Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo. Radiology 177:401–405PubMedGoogle Scholar
  31. 30.
    Moseley ME, Kucharczyk J, Mintorovitch J et al (1990) Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats. AJNR 11:423–429PubMedGoogle Scholar
  32. 31.
    Szafer A, Zhong J, Gore JC (1995) Theoretical model for water diffusion in tissues. Magn Reson Med 33:697–712PubMedCrossRefGoogle Scholar
  33. 32.
    Helpern JA, Dereski MO, Knight RA, Ordidge RJ, Chopp M, Qing ZX (1993) Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia. Magn Reson Imaging 11:241–246PubMedCrossRefGoogle Scholar
  34. 33.
    Warach S, Gaa J, Siewert B, Wielopolski P, Edelman RR (1995) Acute human stroke studied by whole brain planar diffusion-weighted magnetic resonance imaging. Ann Neurol 37:231–241PubMedCrossRefGoogle Scholar
  35. 34.
    Sorensen AG, Buonanno FS, Schwamm L, Lev MH, Huang-Hellinger FR et al (1995) Diffusion and perfusion weighted MR imaging in the clinical diagnosis of acute stroke. Proceedings, Third Meeting of the Society of Magnetic Resonance, p 81Google Scholar
  36. 35.
    Lo EH, Matsumoto K, Pierce AR, Garrido L, Luttinger D (1994) Pharmacological reversal of acute changes in diffusion-weighted magnetic resonance imaging in focal cerebral ischemia. J Cereb Blood Flow Meta 14:597–603CrossRefGoogle Scholar
  37. 36.
    Basser PJ, Mattiello J, Le Bihan D (1994) MR diffusion tensor spectroscopy and imaging. Biophys J 66:259–267PubMedCrossRefGoogle Scholar
  38. 37.
    Moseley ME, Kucharczyk J, Mintorovitch J et al (1990) Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats. AJNR 11:423–429PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • R. Turner

There are no affiliations available

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