Echo-Planar Imaging of the Abdomen

  • P. Reimer
  • R. Ladebeck

Abstract

Magnetic resonance imaging (MRI) of the abdomen has been of limited clinical value because of long examination times, motion artifacts, and lack of suitable contrast agents [1–7]. Echo-planar MRI (EPI) and its derivatives have been developed to provide ultrafast imaging capability thus eliminating motion-related volume-averaging and phase-encoding artifacts (Fig. 1) combined with the acquisition of purely T2-weighted images using single-excitation techniques (TR = ∞) [8–19]. Major disadvantages in the past have been the need for specifically designed systems, suboptimal resolution (64×64 or 64×128), narrow magnet bores, limited multi-slice capability, and restricted slice orientation [20–23]. Limitations due to poor signal-to-noise ratio (SNR) have encouraged a trend from low-field MR systems to middle- or high-field MR systems [1, 10, 20, 24–26]. EPI is currently being prepared for installation into clinical MR systems by various manufactures [1, 9, 20, 24] because recent technical advances provide multi-slice capability, almost free-slice orientation, anatomical resolution, and sufficient SNR values [1, 27, 28]. EPI and its derivatives can be performed on conventional scanners, and a wide spectrum of pulse sequences is available [14, 15, 17–19, 29]. The purpose of this chapter is to describe the potential clinical applications of abdominal EPI.

Keywords

Ferrite Adenocarcinoma Pancreatitis Barium Glucagon 

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References

  1. 1.
    Cohen MS, Weisskoff RM (1991) Ultra-fast imaging. Magn Reson Imaging 9:1–37PubMedCrossRefGoogle Scholar
  2. 2.
    Saini S, Modic MT, Hamm B, Hahn PF (1991) Advances in contrast-enhanced MR imaging. AJR 156:235–254Google Scholar
  3. 3.
    Mitchell DG, Vinitski S, Saponaro S, Tasciyan T, Burk DL, Rifkin MD (1991) Liver and pancreas: improved spin-echo T1 contrast by shorter echo time and fat suppression at 1.5T. Radiology 178:67–71PubMedGoogle Scholar
  4. 4.
    Mitchell DG (1991) Rapid-acquisition spin-echo MR imaging of the liver: a critical view. Radiology 179:609–612PubMedGoogle Scholar
  5. 5.
    Mirowitz SA, Lee JKT (1991) Optimizing MR imaging of the abdomen: the case for rapid acquisition spin-echo MR imaging. Radiology 179:612–614PubMedGoogle Scholar
  6. 6.
    Brasch RC (1992) New directions in the development of MR imaging contrast media. Radiology 183:1–11PubMedGoogle Scholar
  7. 7.
    Patten RM, Moss AA, Fenton TA, Elliot S (1992) OMR, a positive bowel contrast agent for abdominal and pelvic MR imaging: safety and imaging characteristics. JMRI 2:25–34PubMedCrossRefGoogle Scholar
  8. 8.
    Mansfield P, Maudsley AA (1977) Planar spin imaging by NMR. J Magn Reson 27:101–107CrossRefGoogle Scholar
  9. 9.
    Pykett IL, Rzedzian RR (1987) Instant images of the body by magnetic resonance. Magn Reson Med 5:563–571PubMedCrossRefGoogle Scholar
  10. 10.
    Stehling MJ, Charnley RM, Blamire AM et al (1990) Ultrafast magnetic resonance scanning of the liver with echo-planar imaging. Br J Radiol 63:430PubMedCrossRefGoogle Scholar
  11. 11.
    Haase A (1990) Snapshot FLASH MRI: application to T1, T2, and chemical-shift imaging. Magn Reson Med 13:77–89PubMedCrossRefGoogle Scholar
  12. 12.
    Edelman RR, Wallner B, Singer A, Atkinson DJ, Saini S (1990) Segmented turboFlash: method for breath-hold MR imaging of the liver with flexible contrast. Radiology 177:515–521PubMedGoogle Scholar
  13. 13.
    Mirowitz SA, Lee JKT, Brown JJ, Eilenberg SS, Heiken JP, Perman WH (1990) Rapid acquisition spin-echo (RASE) MR imaging: a new technique for reduction of artifacts and acquisition time. Radiology 175:131–135PubMedGoogle Scholar
  14. 14.
    Feinberg D, Oshio K (1991) GRASE (gradient- and spin-echo) MR imaging: new fast clinical imaging technique. Radiology 181:280–293Google Scholar
  15. 15.
    Oshio K, Feinberg D (1991) GRASE (gradient- and spin-echo): a novel fast MR imaging technique. Magn Reson Med 20:344–349PubMedCrossRefGoogle Scholar
  16. 16.
    Wehrli FW (1991) Fast-scan magnetic resonance: principles and applications. Raven Press, New YorkGoogle Scholar
  17. 17.
    Melki PS, Jolesz FA, Mulkern RV (1992) Partial RF echo-planar imaging with the FAISE method II. Contrast equivalence with spin-echo-sequences. Magn Reson Med 26:342–354PubMedCrossRefGoogle Scholar
  18. 18.
    Melki PS, Jolesz FA, Mulkern RV (1992) Partial RF echo-planar imaging with the FAISE method I. Experimental and theoretical assessment of artifact. Magn Reson Med 26:328–341PubMedCrossRefGoogle Scholar
  19. 19.
    Kiefer B, Hausmann R (1993) Turbo-gradient-spin echo: technique, implementation and comparison to turbo-spin-echo-imaging. 8th European congress of radiology, Vienna, p 186Google Scholar
  20. 20.
    Rzedzian RR, Pykett IL (1987) Instant images of the body by magnetic resonance. Magn Reson Med 5:563–571PubMedCrossRefGoogle Scholar
  21. 21.
    Crooks LE, Arakawa M, Hylton NM et al (1988) Echo-planar pediatric imager. Radiology 166:157–163PubMedGoogle Scholar
  22. 22.
    Saini S, Stark DD, Rzedzian RR et al (1989) Forty-millisecond MR imaging of the abdomen at 2.0 T. Radiology 173:111–116PubMedGoogle Scholar
  23. 23.
    Stehling MJ, Howseman AM, Ordidge RJ et al (1989) Whole-body echo-planar MR imaging at 0.5 T. Radiology 170:257–263PubMedGoogle Scholar
  24. 24.
    Mansfield P (1977) Multi-planar image formation using NMR spin echoes. J Phys (Solid State Phys) C10:L55–58CrossRefGoogle Scholar
  25. 25.
    Ordidge RJ, Howseman A, Coxon R et al (1989) Snapshot imaging at 0.5 T using echo-planar techniques. Magn Reson Med 10:227–240PubMedCrossRefGoogle Scholar
  26. 26.
    Mansfield P, Coxon R, Glover P, Bowtell R (1993) High resolution echo-planar imaging at 3.0 T. SMRM, 12th annual meeting, New York, p 480Google Scholar
  27. 27.
    Fahrzaneh F, Riederer SJ (1988) Hybrid imaging with use of gradient-recalled echoes (abstract). Radiology 169 (P):379Google Scholar
  28. 28.
    Weisskoff RM, Cohen MS, Rzedzian RR (1993) Nonaxial whole-body instant imaging. Magn Reson Med 29:796–803PubMedCrossRefGoogle Scholar
  29. 29.
    Butts K, Riederer SJ, Ehman RL, Felmlee JP, Grimm RC (1993) Echo-planar imaging of the liver with a standard MR imaging system. Radiology 189:259–264PubMedGoogle Scholar
  30. 30.
    Feinberg D, Hale JD, Watts JC, Kauffman L, Mark A (1986) Halving MR imaging time by conjugation: demonstration at 3.5 kG. Radiology 161:527–531PubMedGoogle Scholar
  31. 31.
    Hennig J, Nauerth A, Friedburg H (1986) RARE imaging: a fast method for clinical MR. Magn Reson Med 3:823–833PubMedCrossRefGoogle Scholar
  32. 32.
    Reimer P, Saini S, Hahn PF, Brady TJ, Cohen MS (1994) Clinical application of abdominal echoplanar imaging: Optimization using a retrofitted EPI system. JCAT 18:673–679Google Scholar
  33. 33.
    Stark DD, Wittenberg J, Butch RJ, Ferrucci JT (1987) Hepatic metastases: randomized, controlled comparison of detection with MR imaging and CT. Radiology 165:399–406PubMedGoogle Scholar
  34. 34.
    Nelson RC, Chezmar JL, Sugarbaker PH, Bernardino ME (1989) Hepatic tumors: comparison of CT during arterial portography, delayed CT, and MR imaging for preoperative evaluation. Radiology 172:27–34PubMedGoogle Scholar
  35. 35.
    Heiken JP, Weyman PJ, Lee JKT et al (1989) Detection of focal hepatic masses: prospective evaluation with CT, delayed CT, CT during arterial portography, and MR imaging. Radiology 171:47–51PubMedGoogle Scholar
  36. 36.
    Rummeny EJ, Wernecke K, Saini S et al (1992) Comparison between high-field-strength MR imaging and CT for screening of hepatic metastases: a receiver operating characteristics analysis. Radiology 182:879–886PubMedGoogle Scholar
  37. 37.
    Nelson RC, Thompson GH, Chezmar JL, Harned II RK, Fernandez MP (1992) CT during arterial portography: diagnostic pitfalls. Radiographics 12:705–718PubMedGoogle Scholar
  38. 38.
    Oshio K, Jolesz FA (1993) Fast MRI by creating multiple spin echoes in a CPMG sequence. Magn Reson Med 30:251–255PubMedCrossRefGoogle Scholar
  39. 39.
    Jakob PM, Haase A (1992) Scan time reduction in snapshot FLASH MRI. Magn Reson Med 24:391–396PubMedCrossRefGoogle Scholar
  40. 40.
    Semelka RC, Simm FC, Recht M, Deimling M, Lenz G, Laub GA (1991) T1-weighted sequences for MR imaging of the liver: comparison of three techniques for single-breath whole-volume acquisition at 1.0 and 1.5 T. Radiology 180:629–635PubMedGoogle Scholar
  41. 41.
    Butts RK, Farzaneh F, Riederer SJ, Rydberg JN, Grimm RC (1991) T2-weighted spin-echo pulse with variable repetition and echo times for reduction of MR image acquisition time. Radiology 180:551–556PubMedGoogle Scholar
  42. 42.
    Holsinger-Bampton AE, Riederer SJ, Campeau NG, Ehman RL, Johnson CD (1991) T1-weighted snapshot gradient-echo MR imaging of the abdomen. Radiology 181:25–32PubMedGoogle Scholar
  43. 43.
    Semelka RC, Shoenut P, Kroeker MA et al (1992) Focal liver disease: comparison of dynamic contrast-enhanced CT and T2-weighted fat suppressed, FLASH, and dynamic gadolinium-enhanced MR imaging at 1.5 T. Radiology 184:687–694PubMedGoogle Scholar
  44. 44.
    Pauly J, Spielman D, Macovski A (1993) Echo-planar spin-echo and inversion pulses. Magn Reson Med 29:776–782PubMedCrossRefGoogle Scholar
  45. 45.
    Saini S, Hahn PF, Reimer P, Nadeau KA, Cohen MS, Mueller PR (1991) Ultrafast MR Imaging of the liver: analysis of pulse sequence performance. Society of Magnetic Resonance in Medicine, 10th annual scientific meeting and exhibition, San Francisco, USA, p 24Google Scholar
  46. 46.
    Reimer P, Saini S, Hahn PF, Cohen MS, Brady TJ (1993) Klinische Anwendung der echoplanaren MR-Tomographie in der Detektion fokaler Leberläsionen: Ergebnisse einer quantitativen Untersuchung. RÖFO 159:16–21PubMedGoogle Scholar
  47. 47.
    Stehling MJ, Ordidge RJ, Coxon R, Mansfield P (1990) Inversion-recovery echo planar imaging (IR-EPI) at 0.5 T. Magn Reson Med 13:514–517PubMedCrossRefGoogle Scholar
  48. 48.
    Bydder GM, Young IR (1985) MR Imaging: clinical use of the inversion recovery sequence. JCAT 9:659–675Google Scholar
  49. 49.
    Reimer P, Ladebeck R, Rummney EJ, Repp H, Peters PE, Schmitt F (1994) Detection of focal liver lesions with EPI: preliminary clinical results with CT comparison. MRM 32:733–737Google Scholar
  50. 50.
    Bruder H, Fischer H, Reinfelder H-E, Schmitt F (1992) Image reconstruction for echo-planar imaging with nonequidistant k-space sampling. Magn Reson Med 23:311–323PubMedCrossRefGoogle Scholar
  51. 51.
    Bampton AEH, Riederer SJ (1992) Improved efficiency in 2DFT magnetization-prepared rapid gradient echo imaging: application to abdominal imaging. Magn Reson Med 25:195–203PubMedCrossRefGoogle Scholar
  52. 52.
    Ortendahl AD, Kaufman L, Kramer DM (1992) Analysis of hybrid imaging techniques. Magn Reson Med 26:155–173PubMedCrossRefGoogle Scholar
  53. 53.
    Constable RT, Gore JC (1992) The loss of small objects in variable TE imaging: implications for FSE, RARE, and EPI. Magn Reson Med 28:9–24PubMedCrossRefGoogle Scholar
  54. 54.
    Karhunen PJ (1986) Benign hepatic tumours and tumour like conditions in men. J Clin Pathol 39:183–189PubMedCrossRefGoogle Scholar
  55. 55.
    Wittenberg J, Stark DD, Forman BH et al (1988) Differentiation of hepatic metastases from hepatic hemangiomas and cysts by using MR imaging. AJR 151:79–84PubMedGoogle Scholar
  56. 56.
    Ohtomo K, Itai Y, Furui S, Yashiro N, Yoshikawa K, Iio M (1985) Hepatic tumors: differentiation by transverse relaxation time (T2) of magnetic resonance imaging. Radiology 155:421–423PubMedGoogle Scholar
  57. 57.
    Egglin TK, Rummeny EJ, Stark DD, Wittenberg J, Saini S, Ferrucci JT (1990) Hepatic tumors: quantitative tissue characterization with MR imaging. Radiology 155:55–59Google Scholar
  58. 58.
    Itoh K, Saini S, Hahn PF, Inam N, Ferrucci JT (1990) Differentiation between small hemangiomas and metastases on MR images: importance of size-specific quantitative criteria. AJR 155:61–66PubMedGoogle Scholar
  59. 59.
    Goldberg MA, Hahn PF, Saini S et al (1993) Value of T1 and T2 relaxation times from echoplanar MR imaging in the characterization of focal hepatic lesions. AJR 160:1011–1017PubMedGoogle Scholar
  60. 60.
    Goldberg MA, Hahn PF, Saini S, Egglin TK, Mueller PR (1991) Differentiation between hemangiomas and metastases of the liver with ultrafast MR imaging: preliminary results with T2 calculations. AJR 157:727–730PubMedGoogle Scholar
  61. 61.
    Reimer P, Saini S, Tombach B et al (1996) Echoplanar imaging (EPI) des Abdomens. Radiologe (in press)Google Scholar
  62. 62.
    Hamm B, Fischer E, Taupitz M (1990) Differentiation of hepatic hemangiomas from metastases by dynamic contrast-enhanced MR imaging. J Comput Assist Tomogr 14:205–216PubMedCrossRefGoogle Scholar
  63. 63.
    Saini S, Hahn PF, Cohen MS, Reimer P, Campbell T, Brady TJ (1993) Dynamic gadolinium-enhanced echo-planar MR Imaging of the liver. RSNA, Chicago, p 116Google Scholar
  64. 64.
    Chezmar JL, Rumancik WM, Megibow AJ, Hulnik DH, Nelson RC, Bernardino ME (1988) Liver and abdominal screening in patients with cancer: CT versus MR imaging. Radiology 168:43–47PubMedGoogle Scholar
  65. 65.
    Ehman RL, McNamara MT, Brasch RC, Felmlee JP, Gray JE, Higgins CB (1986) Influence of physiologic motion on the appearance of MR images. Radiology 159:777–782PubMedGoogle Scholar
  66. 66.
    Henkelman RM, Bronskill MJ (1987) Artifacts in magnetic resonance imaging. Rev Magn Reson Med 2:1–126Google Scholar
  67. 67.
    Hahn PF, Saini S, Cohen MS, Goldberg M, Reimer P, Mueller PR (1992) An aqueous gastrointestinal contrast agent for use in echo-planar MR imaging. Magn Reson Med 25:380–383PubMedCrossRefGoogle Scholar
  68. 68.
    Stehling MJ, Evans DF, Lamont G et al (1989) Gastrointestinal tract: dynamic MR studies with echo-planar imaging. Radiology 171:41–46PubMedGoogle Scholar
  69. 69.
    Reimer P, Saini S, Hahn PF, Mueller PR, Brady TJ, Cohen MS (1992) Techniques for high-resolution echoplanar MR imaging of the pancreas. Radiology 182:175–179PubMedGoogle Scholar
  70. 70.
    Hahn PF, Stark DD, Lewis JM et al (1989) First clinical trial of a new superparamagnetic iron oxide for use as an oral superparamagnetic contrast agent in MR imaging. Radiology 175:695–700Google Scholar
  71. 71.
    Tscholakoff D, Hricak H, Thoeni R, Winkler ML, Margulis AR (1987) MR imaging in the diagnosis of pancreatic disease. AJR 148:703–709PubMedGoogle Scholar
  72. 72.
    Steiner E, Stark DD, Hahn PF et al (1989) Imaging of pancreatic neoplasms: comparison of MR and CT. AJR 151:487–491Google Scholar
  73. 73.
    Semelka RC, Ascher SM (1993) MR imaging of the pancreas. Radiology 188:593–602PubMedGoogle Scholar
  74. 74.
    Müller MF, Prasad PV, Siewert B et al (1993) Abdominal diffusion mapping using a whole body echo planar system. 12th annual meeting, New York, p 45Google Scholar
  75. 75.
    Butts RK, Riederer SJ (1992) Analysis of flow effects in echo-planar imaging. JMRI 2:285PubMedCrossRefGoogle Scholar
  76. 76.
    Goldberg MA, Yucel EK, Saini S, Hahn PF, Kaufman JA, Cohen MS (1993) MR angiography of the portal and hepatic venous systems: preliminary experience with echoplanar Imaging. AJR 160:35–40PubMedGoogle Scholar
  77. 77.
    Crawley AM, Cohen MS, Yucel EK, Poncelet B, Brady TJ (1991) Single-shot magnetic resonance imaging: applications to angiography. Cardiovasc Intervent Radiol 15:32–42Google Scholar
  78. 78.
    Firmin D, Klipstein R, Hounsfield G, Paley M, Longmore D (1989) Echo planar high resolution flow velocity mapping. Magn Reson Med 12:316–327PubMedCrossRefGoogle Scholar
  79. 79.
    Feinberg D, Jakab P (1990) Tissue perfusion in humans studied by Fourier velocity distribution, line scan, and echo planar imaging. Magn Reson Med 16:280–293PubMedCrossRefGoogle Scholar
  80. 80.
    Saini S, Stark DD, Brady TJ, Wittenberg J, Ferrucci JT (1986) Dynamic spin-echo MRI of liver cancer using gadolinium-DTPA: animal investigation. AJR 147:357–362PubMedGoogle Scholar
  81. 81.
    Hamm B, Wolf KJ, Felix R (1987) Conventional and rapid MR imaging of the liver with GD-DTPA. Radiology 164:313–320PubMedGoogle Scholar
  82. 82.
    Edelman RR, Siegel JB, Singer A, Dupuis K, Longmaid HE (1989) Dynamic MR imaging of the liver with Gd-DTPA: initial clinical results. AJR 153:1213–1219PubMedGoogle Scholar
  83. 83.
    Villringer A, Rosen BR, Belliveau JW et al (1988) Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 6:164–174PubMedCrossRefGoogle Scholar
  84. 84.
    Fisel CR, Ackerman JL, Buxton RB et al (1991) MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology. Magn Res Med 17:336–347CrossRefGoogle Scholar
  85. 85.
    White DL, Aicher KP, Tzika AA, Kucharzyk J, Engelstad BL, Moseley ME (1992) Iron-dextran as a magnetic susceptibility contrast agent: flow-related contrast effects in the T2-weighted spin-echo MRI of normal rat and cat brain. Mag Reson Med 24:14–28CrossRefGoogle Scholar
  86. 86.
    Reimer P, Saini S, Kwong KK, Cohen MS, Weissleder R, Brady TJ (1994) Dynamic gadopentetate dimeglumine enhanced echoplanar MR Imaging of the liver: effect of pulse sequence and dose on liver enhancement. JMRI 4:1–5CrossRefGoogle Scholar
  87. 87.
    Greif WL, Buxton R, Lauffer RB, Saini S, Vincent AC (1985) Optimization of pulse sequences for imaging of hepato-biliary contrast agents. Radiology 157:461–466PubMedGoogle Scholar
  88. 88.
    Rummeny EJ, Stober U, Adolph J et al (1991) turbo-FLASH MR imaging: perfusion patterns of hepatic tumors. ARRS, Boston May 1991, p 203Google Scholar
  89. 89.
    Weissleder R, Elizondo G, Wittenberg J, Rabito C, Bengele HH, Josephson L (1990) Ultra-small superparamagnetic iron oxide (USPIO): characterization of a new class of MR contrast agents. Radiology 175:489–493PubMedGoogle Scholar
  90. 90.
    Lauffer RB, Vincent AC, Padmanabhan S et al (1987) Hepatobiliary MR contrast agents: 5-substituted Iron-EHPG derivatives. Magn Res Med 4:582–590CrossRefGoogle Scholar
  91. 91.
    Reimer P, Weissleder R, Lee AS, Wittenberg J, Brady TJ (1990) Receptor imaging: application to MR imaging of liver cancer. Radiology 177:729–734PubMedGoogle Scholar
  92. 92.
    Reimer P, Kwong KK, Weisskoff R, Cohen MS, Brady TJ, Weissleder R (1992) Dynamic signal changes in liver with superparamagnetic MR contrast agents. JMRI 2:177–181PubMedCrossRefGoogle Scholar
  93. 93.
    Moss AA, Kressel HY, Korobkin M, Goldberg HI, Rohlfing BM, Brasch RC (1978) The effect of gastrografin and glucagon on CT scanning of the pancreas: a blind clinical trial. Radiology 126:711PubMedGoogle Scholar
  94. 94.
    Hahn PF, Stark DD, Saini S, Lewis JM, Wittenberg J, Ferrucci JT (1987) Ferrite particles for bowel contrast in MR imaging: design issues and feasibility studies. Radiology 164:37–41PubMedGoogle Scholar
  95. 95.
    Laniado M, Kornmesser W, Hamm B, Clauss W, Weinmann HJ, Felix R (1988) MR imaging of the gastrointestinal tract: value of GD-DTPA. AJR 150:817–821PubMedGoogle Scholar
  96. 96.
    Kaminsky S, Laniado M, Gogoll M et al (1991) Gadopentate dimeglumine as a bowel contrast agent: Safety and efficacy. Radiology 178:503–508PubMedGoogle Scholar
  97. 97.
    Ros PR, Steinman RM, Torres GM et al (1991) The value of barium as a gastrointestinal contrast agent in MR imaging: a comparison study in normal volunteers. AJR 157:761–767PubMedGoogle Scholar
  98. 98.
    Reimer P, Schmitt F, Ralf Ladebeck R, Graessner J, Schaffer B (1993) Evaluation of potential gastrointestinal contrast agents for echoplanar MR imaging. EJR 3:487–492Google Scholar
  99. 99.
    Weissleder R, Bogdanov A, Papisov M (1992) Drug targeting in magnetic resonance imaging. Magn Reson Q 8:55–63PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • P. Reimer
  • R. Ladebeck

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