Epidemiology of Osteoporosis

  • P. D. Ross

Abstract

Fractures related to osteoporosis affect more than half of women and about one-third of men in the United States during their lifetimes, making it one of the most prevalent chronic health conditions among the elderly. Many persons currently have low bone density and are at risk but have not yet experienced fractures. This chapter reviews how common osteoporosis is, based on two criteria (low bone density and frequency of fractures), and also reviews the extent of health and economic impacts.

Keywords

Arthritis Depression Europe Torque Estrogen 

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References

  1. 1.
    Consensus Development Conference (1991) Prophylaxis and treatment of osteoporosis. Am J Med 90: 107–110CrossRefGoogle Scholar
  2. 2.
    Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9: 1137–1141PubMedCrossRefGoogle Scholar
  3. 3.
    Ross PD, Davis JW, Epstein RS, Wasnich RD (1991) Pre-existing fractures and bone mass predict vertebral fracture in women. Ann Intern Med 114: 919–923PubMedGoogle Scholar
  4. 4.
    Ross PD, Genant HK, Davis JW, Miller P, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteo Int 3: 120–127CrossRefGoogle Scholar
  5. 5.
    Black DM, Nevitt MC, Palermo L et al (1994) Prediction of new vertebral deformities (abstract). J Bone Miner Res 9: S135Google Scholar
  6. 6.
    Cummings SR, Nevitt MC, Browner WS et al (1995) Risk factors for hip fracture in white women. N Engl J Med 332: 767–773PubMedCrossRefGoogle Scholar
  7. 7.
    Hillman L (1996) Bone mineral acquisition in utero and during infancy and childhood. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis. Academic, New York, pp 449–464Google Scholar
  8. 8.
    Recker RR, Davies KM, Hinders SM, Heaney RP, Stegman MR, Kimmel DB (1992) Bone gain in young adult women. JAMA 268: 2403–2408PubMedCrossRefGoogle Scholar
  9. 9.
    Bonjour J-P, Rizzoli R (1996) Bone acquisition in adolescence. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis. Academic, New York, pp 465–476Google Scholar
  10. 10.
    Lloyd T, Martel JK, Rollings N, Andon MB, Kuhn H, Demers LM, Eggli DF, Kieselhorst K, Chinchilli VM (1996) The effect of calcium supplementation and Tanner stage on bone density and area in teenage women. Osteoporosis Int 6: 276–283CrossRefGoogle Scholar
  11. 11.
    Kröger H, Kotaniemi A, Kröger L,Alhava E (1993) Development of bone mass and bone density of the spine and femoral neck–a prospective study of 65 children and adolescents. Bone Miner 23: 171–182Google Scholar
  12. 12.
    Hagino H, Yamamoto K, Teshima R, Kishimoto H, Nakamura T (1990) Fracture incidence and bone mineral density of the distal radius in Japanese children. Acta Orthop Trauma Surg 109: 262–264CrossRefGoogle Scholar
  13. 13.
    Teegarden D, Proux WR, Martin BR et al (1995) Peak bone mass in young women. J Bone Miner Res 10: 711–716PubMedCrossRefGoogle Scholar
  14. 14.
    Hagino H, Yamamoto K, Teshima R, Kishimoto H, Kagawa T (1992) Radial bone mineral changes in pre-and postmenopausal healthy Japanese women: cross-sectional and longitudinal studies. J Bone Miner Res 7: 147–152PubMedCrossRefGoogle Scholar
  15. 15.
    Parsons TJ, Prentice A, Smith EA, Cole TJ, Compston JE (1996) Bone mineral mass consolidation in young British adults. J Bone Miner Res 11(2):264–74PubMedCrossRefGoogle Scholar
  16. 16.
    Turner JG, Gilchrist NL, Ayling EM et al (1992) Factors affecting bone mineral density in high school girls. N Z Med J 105: 95–96PubMedGoogle Scholar
  17. 17.
    Cooper C, Cawley M, Bhalla A et al (1995) Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res 10 (6): 940–947PubMedCrossRefGoogle Scholar
  18. 18.
    Ruiz JC, Mandel C, Garabedian M (1995) Influence of spontaneous calcium intake and physical exercise on the vertebral and femoral bone mineral density of children and adolescents. J Bone Miner Res 10: 675–682PubMedCrossRefGoogle Scholar
  19. 19.
    Slemenda CW, Miller JZ, Hui SL, Reister TK, Johnston CC Jr (1991) Role of physical activity in the development of skeletal mass in children. J Bone Miner Res 6: 1227–1233PubMedCrossRefGoogle Scholar
  20. 20.
    Kröger H, Heikkinen J, Laitinen K, Kotaniemi A (1992) Dual-energy X-ray absorptiometry in normal women: a cross-sectional study of 717 Finnish volunteers. Osteo Int 2: 135–140CrossRefGoogle Scholar
  21. 21.
    Kröger H, Kotaniemi A, Vainia P, Alhava E (1992) Bone density of the spine and femur in children by dual-energy X-ray absorptiometry. Bone Miner 17: 75–85PubMedCrossRefGoogle Scholar
  22. 22.
    Snow CM, Shaw JM, Matkin CC (1996) Physical activity and risk for osteoporosis. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis. Academic, New York, pp 511–528Google Scholar
  23. 23.
    Prior JC, Vigna YM, Schechter MT, Burgess AE (1990) Spinal bone loss and ovulatory disturbances. N Engl J Med 323: 1221–1227PubMedCrossRefGoogle Scholar
  24. 24.
    Sowers MR, Clark MK, Hollis B, Wallace RB, Jannausch M (1992) Radial bone mineral density in pre-and postmenopausal women: a prospective study of rates and risk factors for loss. J Bone Miner Res 7: 647–657PubMedCrossRefGoogle Scholar
  25. 25.
    Prior JC, Vigna YM, Barr SI, Kennedy S, Schulzer M, Li DKB (1996) Ovulatory premenopausal women lose cancellous spinal bone: a five year prospective study. Bone 18 (3): 261–267PubMedCrossRefGoogle Scholar
  26. 26.
    Riggs BL, Wahner HW, Melton LT III, Richelson LS, Judd HL, Offord KP (1986) Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral loss before menopause. J Clin Invest 77: 1487–1491PubMedCrossRefGoogle Scholar
  27. 27.
    Hui SL, Evans R, Johnston CC, Slemenda CW, Peacock M (1996) Patterns of growth and loss of BMD at the spine and hip in white females (abstract). J Bone Miner Res 11 [Suppl 1]:S104Google Scholar
  28. 28.
    Citron JT, Ettinger B, Genant HK (1995) Spinal bone mineral loss in estrogen-replete, calcium-replete premenopausal women. Osteoporosis Int 5: 228–233CrossRefGoogle Scholar
  29. 29.
    Elders PJM, Netelenbos JC, Lips P, van Ginkel FC, van der Stelt PF (1988) Accelerated vertebral bone loss in relation to the menopause: a cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age. Bone Miner 5: 11–19PubMedCrossRefGoogle Scholar
  30. 30.
    Nilas L, Christiansen C (1988) Rates of bone loss in normal women: evidence of accelerated trabecular bone loss after the menopause. Eur J Clin Invest 18: 529–534PubMedCrossRefGoogle Scholar
  31. 31.
    Davis JW, Ross PD, Wasnich RD, MacLean CJ, Vogel JM (1989) Comparison of cross-sectional and longitudinal measurements of age-related changes in bone mass. J Bone Min Res 4: 351–357CrossRefGoogle Scholar
  32. 32.
    Harris S, Dawson-Hughes B (1992) Rates of change in bone mineral density of the spine, heel, femoral neck and radius in healthy postmenopausal women. Bone Miner 17: 87–95PubMedCrossRefGoogle Scholar
  33. 33.
    Hansen MA, Overgaard K, Christiansen C (1995) Spontaneous postmenopausal bone loss in different skeletal areas–followed up for 15 years. J Bone Miner Res 10: 205–210PubMedCrossRefGoogle Scholar
  34. 34.
    Davis JW, Ross PD,Vogel JM, Wasnich RD (1991) Age-related changes in bone mass among Japanese-American men. Bone Miner 15: 227–236Google Scholar
  35. 35.
    Ensrud KE, Palermo L, Black D et al (1994) Hip bone loss increases with advancing age: longitudinal results from the Study of Osteoporotic Fractures (abstract). J Bone Miner Res 9 [Suppl 1]: S153Google Scholar
  36. 36.
    Greenspan SL, Maitland LA, Myers ER, Krasnow MB, Kido TH (1994) Femoral bone loss progresses with age: a longitudinal study in women over age 65. J Bone Miner Res 9: 1959–1965PubMedCrossRefGoogle Scholar
  37. 37.
    Hannan MT, Kiel DP, Mercier CE, Anderson JJ, Felson DT (1994) Longitudinal bone mineral density (BMD) change in elderly men and women: the Framingham Osteoporosis Study (abstract). J Bone Miner Res 9 [Suppl 1]: S153Google Scholar
  38. 38.
    Ross PD (1994) Risk factors for fracture. In: Cooper C, Reeve J (eds) Spine. State of the art reviews: vertebral osteoporosis, vol 8. Hanley and Belfus, Philadelphia, pp 91–110Google Scholar
  39. 39.
    Ross PD, He Y-F, Davis JW, Epstein RS, Wasnich RD (1994) Normal ranges for bone loss rates. Bone Miner 26: 169–180PubMedCrossRefGoogle Scholar
  40. 40.
    Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton LJ III (1982) Changes in bone mineral density of the proximal femur and spine with aging: differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest 70: 716–723PubMedCrossRefGoogle Scholar
  41. 41.
    Riffs BJ, Hansen MA, Jensen AM, Overgaard K, Christiansen C (1996) Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone 19 (1): 9–12CrossRefGoogle Scholar
  42. 42.
    Sklarin PM, Cummings SR, Nevitt MC, Ensrud K, Black DM (1996) Bone loss is an independent predictor of hip fracture in elderly women with low bone mass. Presented at the International Congress of Endocrinology, June 1996Google Scholar
  43. 43.
    Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK (1992) Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 7: 625–632PubMedCrossRefGoogle Scholar
  44. 44.
    Ross PD, Wasnich RD, Vogel JM (1988) Detection of pre-fracture spinal osteoporosis using bone mineral absorptiometry. J Bone Miner Res 3 (1): 1–11PubMedCrossRefGoogle Scholar
  45. 45.
    Looker AC, Johnston CC Jr, Wahner HW et al (1995) Prevalence of low femoral bone density in older women from NHANES III. J Bone Miner Res 10: 796–802PubMedCrossRefGoogle Scholar
  46. 46.
    Melton LJ III (1995) How many women have osteoporosis now? J Bone Miner Res 10: 175–177PubMedCrossRefGoogle Scholar
  47. 47.
    Melton LJ, Chrischilles EA, Cooper C, Lane AW, Riggs BL (1992) How many women have osteoporosis? J Bone Miner Res 7: 1005–1010PubMedCrossRefGoogle Scholar
  48. 48.
    Owen RA, Melton LJ III, Johnson KA, Ilstrup DM, Riggs BL (1982) Incidence of Colles’ fracture in a North American community. Am J Public Health 72: 605–607PubMedCrossRefGoogle Scholar
  49. 49.
    Melton LJ III, Ilstrup DM, Riggs BL, Beckenbaugh RD (1982) Fifty-year trend in hip fracture incidence. Clin Orthop 162: 144–149PubMedGoogle Scholar
  50. 50.
    Melton LJ III, Cummings SR (1987) Heterogeneity of age-related fractures: implications for epidemiology. Bone Miner 2: 321–331PubMedGoogle Scholar
  51. 51.
    Melton LJ III, Kan SH, Frye MA, Wahner HW, O’Fallon WM, Riggs BL (1989) Epidemiology of vertebral fractures in women. Am J Epidemiol 129: 1000–1011PubMedGoogle Scholar
  52. 52.
    Cooper C (1994) Epidemiology of vertebral fractures in western populations. In: Cooper C, Reeve J (eds) Spine. State of the art reviews: vertebral osteoporosis, vol 8. Hanley and Belfus, Philadelphia, pp 1–21Google Scholar
  53. 53.
    Cooper C, Atkinson EJ, O’Fallon WM, Melton LJ III (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res 7: 221–227PubMedCrossRefGoogle Scholar
  54. 54.
    Ross PD, Davis JW, Epstein RS, Wasnich RD (1994) Pain and disability associated with new vertebral fractures and other spinal conditions. J Clin Epidemiol 47: 231–239PubMedCrossRefGoogle Scholar
  55. 55.
    Cummings SR, Melton LJ III, Felsenberg D et al (1995) Report: assessing vertebral fractures. J Bone Miner Res 10: 518–523Google Scholar
  56. 56.
    Ross PD, Huang C, Davis JW et al (1995) Predicting vertebral deformityusing bone densitometry at various skeletal sites and calcaneus ultrasound. Bone 16: 325–332PubMedCrossRefGoogle Scholar
  57. 57.
    Ross PD, Wasnich RD, Vogel JM (1988) Detection of pre-fracture spinal osteoporosis using bone mineral absorptiometry. J Bone Miner Res 3: 1–11PubMedCrossRefGoogle Scholar
  58. 58.
    Ross PD, Fujiwara S, Huang C et al (1995) Japanese women in Hiroshima have greater vertebral fracture prevalence than Caucasians or Japanese-Americans in the US. Int J Epidemiol 24 (6): 1171–1177PubMedCrossRefGoogle Scholar
  59. 59.
    Ross PD, Wasnich RD, Davis JW, Vogel JM (1991) Vertebral dimension differences between Caucasian populations, and between Caucasians and Japanese. Bone 12: 107–112PubMedCrossRefGoogle Scholar
  60. 60.
    O’Neill TW, Varlow J, Felsenberg D et al (1994) Variation in vertebral height ratios in population studies. J Bone Miner Res 9: 1895–1907PubMedCrossRefGoogle Scholar
  61. 61.
    Kiel DP, Hannan MT, Genant HK, Fels on DT (1994) Prevalence and incidence of vertebral fractures in the elderly: initial results from the Framingham Study (abstract). J Bone Miner Res 9 [Supp11]: S129Google Scholar
  62. 62.
    Melton LJ III, Riggs BL (1985) Risk factors for injury after a fall. Clin Geriatr Med 1 (3): 525–539PubMedGoogle Scholar
  63. 63.
    Fisher ES, Baron JA, Malenka DJ et al (1991) Hip fracture incidence and mortality in New England. Epidemiology 2: 116–122PubMedCrossRefGoogle Scholar
  64. 64.
    Gallagher JC, Melton LJ III, Riggs BL, Bergstrath E (1980) Epidemiology of fractures of the proximal femur in Rochester, Minnesota. Clin Orthopaed Relat Res 150: 163–171Google Scholar
  65. 65.
    Farmer ME, White LR, Brody JA, Bailey KR (1984) Race and sex differences in hip fracture incidence. Am J Publ Health 74: 1374–1380CrossRefGoogle Scholar
  66. 66.
    Melton LT III (1993) Epidemiology of age-related fractures. In: Avioli LV (ed) The osteoporotic syndrome. Detection, prevention, and treatment, 3rd edn. Wiley-Liss, New York, pp 17–38Google Scholar
  67. 67.
    Karagas MR, Lu-Yao GL, Barrett JA, Beach ML, Baron JA (1996) Heterogeneity of hip fracture: age, race, sex, and geographic patterns of femoral neck and trochanter fractures among the US elderly. Am J Epidemio11 43: 677–682Google Scholar
  68. 68.
    Schneider EL, Guralnik JM (1990) The ageing of America: impact on health care costs. JAMA 263: 2335–2340PubMedCrossRefGoogle Scholar
  69. 69.
    Cummings SR, Rubin SM, Black D (1990) The future of hip fractures in the United States: numbers, costs, and potential effects of postmenopausal estrogen. Clin Orthop 252: 163–166PubMedGoogle Scholar
  70. 70.
    Cooper C, Campion G, Melton LJ III (1992) Hip fractures in the elderly: a world-wide projection. Osteoporosis Int 2: 285–289CrossRefGoogle Scholar
  71. 71.
    US Congress, Office of Technology Assessment (1994) Hip fracture outcomes in people age fifty and over - background paper, OTA-BP-H-12o. US Government Printing Office, Washington DCGoogle Scholar
  72. 72.
    Cooper C, Melton LJ III (1996) Magnitude and impact of osteoporotic fractures. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis. Academic, San Diego, pp 419–434Google Scholar
  73. 73.
    Seeley DG, Browner WS, Nevitt MC, Genant HK, Scott JC, Cummings SR (1991) Which fractures are associated with low appendicular bone mass in elderly women? Ann Intern Med 115: 837–842PubMedGoogle Scholar
  74. 74.
    Seeley DG, Browner WS, Nevitt MC, Genant HK, Cummings SR (1995) Almost all fractures are osteoporotic (abstract). J Bone Miner Res 10 [Sup-pl 1]: S468Google Scholar
  75. 75.
    Kanis JA, Pitt FA (1992) Epidemiology of osteoporosis. Bone 13: S7 - S15PubMedCrossRefGoogle Scholar
  76. 76.
    Hayes WC, Myers ER, Morris JN, Gerhart TN, Yett HS, Lipsitz LA (1993) Impact near the hip dominates fracture risk in elderly nursing home residents who fall. Calcif Tissue Int 52: 192–198PubMedCrossRefGoogle Scholar
  77. 77.
    Solgaard S, Petersen VS (1985) Epidemiology of distal radius fractures. Acta Orthop Scand 56: 391–393PubMedCrossRefGoogle Scholar
  78. 78.
    Nevitt MC, Cummings SR (1993) Type of fall and risk of hip and wrist fractures: the study of osteoporotic fractures. The Study of Osteoporotic Fractures Research Group. J Am Geriatr Soc 41: 1226–1234PubMedGoogle Scholar
  79. 79.
    Riggs BL, Melton LJ (1986) Involutional osteoporosis. N Engl J Med 314: 1676–1686PubMedCrossRefGoogle Scholar
  80. 80.
    Jacobsen SJ, Cooper C, Gottlieb MS, Goldberg J, Yahnke DP, Melton LT III (1992) Hospitalization with vertebral fracture among the aged: a national population-based study, 1986–1989. Epidemiology 3: 515–518PubMedCrossRefGoogle Scholar
  81. 81.
    Johnell O, Gullberg B, Allander E, Kanis JA, the MEDOS Study Group (1992) The apparent incidence of hip fracture in Europe: a study of national register sources. Osteoporosis Int 2: 298–302CrossRefGoogle Scholar
  82. 82.
    Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA (1990) Regional variation in the incidence of hip fracture: US white women aged 65 years and older. JAMA 264: 500–502PubMedCrossRefGoogle Scholar
  83. 83.
    Obrant KJ, Bengner U, Johnell O, Nilsson BE, Sernbo I (1989) Increasing age-adjusted risk of fragility fractures. Calcif Tissue Int 44: 157–167PubMedCrossRefGoogle Scholar
  84. 84.
    Cooper C, Atkinson EJ, Kotowicz M, O’Fallon WM, Melton LJ III (1992) Secular trends in the incidence of postmenopausal osteoporosis. Calcif Tissue Int 51: 100–104PubMedCrossRefGoogle Scholar
  85. 85.
    Melton LJ III, O’Fallon WM, Riggs BL (1987) Secular trends in the incidence of hip fractures. Calcif Tissue Int 41: 57–64PubMedCrossRefGoogle Scholar
  86. 86.
    Lauritzen JB, Schwarz P, Lund B, McNair P, Transbol I (1993) Changing incidence and residual lifetime risk of common osteoporosis-related fractures. Osteoporosis Int 3: 127–132CrossRefGoogle Scholar
  87. 87.
    Spector TD, Cooper C, Lewis AF (1990) Trends in admissions for hip fracture in England and Wales, 1968–85. BMJ 300: 1173–1174PubMedCrossRefGoogle Scholar
  88. 88.
    Cummings SR, Black DM, Rubin SM (1989) Lifetime risks of hip, Colles’, or vertebral fracture and coronary heart disease among white postmenopausal women. Arch Intern Med 149: 2445–2448PubMedCrossRefGoogle Scholar
  89. 89.
    Grisso JA, Chiu GY, Maislin G, Steinmann WC, Portale J (1991) Risk factors for hip fractures in men: a preliminary study. J Bone Miner Res 6: 865–868PubMedCrossRefGoogle Scholar
  90. 90.
    Chrischilles EA, Shireman T, Wallace R (1994) Costs and health effects of osteoporotic fractures. Bone 15: 377–386PubMedCrossRefGoogle Scholar
  91. 91.
    Cooper C, Atkinson EJ, Jacobsen SJ, O’Fallon WM, Melton LJ III (1993) Population-based study of survival after osteoporotic fractures. Am J Epidemiol 137: 1001–1005PubMedGoogle Scholar
  92. 92.
    Magaziner J, Simonsick EM, Kashner TM, Hebel JR, Kenzora JE (1989) Survival experience of aged hip fracture patients. Am J Public Health 79: 274–278PubMedCrossRefGoogle Scholar
  93. 93.
    Weiss NS, Liff JM, Ure CL, Ballard JH, Abbott GH, Daling JR (1983) Mortality in women following hip fracture. J Chron Dis 36: 879–882PubMedCrossRefGoogle Scholar
  94. 94.
    Browner WS, Seeley DG, Vogt TM, Cummings SR (1991) Non-trauma mortality in elderly women with low bone mineral density. Lancet 338: 355–358PubMedCrossRefGoogle Scholar
  95. 95.
    Browner WS, Pressman AR, Nevitt MC, Cauley JA, Cummings SR (1993) Association between low bone density and stroke in elderly women. The Study of Osteoporotic Fractures. Stroke 24: 940–946PubMedCrossRefGoogle Scholar
  96. 96.
    Gärdsell P, Johnell O (1993) Bone mass-a marker of biologic age? Clin Orthop 287: 90–93PubMedGoogle Scholar
  97. 97.
    Kanis JA (1993) The incidence of hip fracture in Europe. Osteoporosis Int [Suppl] 1: S10 - S15CrossRefGoogle Scholar
  98. 98.
    Melton LJ III (1993) Hip fractures: a worldwide problem today and tomorrow. Bone 14 [Suppl]: S1 - S8PubMedCrossRefGoogle Scholar
  99. 99.
    Jensen JS, Tondevold E, Sorensen PH (1980) Costs of treatment of hip fractures. Acta Orthop Scand 51: 289–296PubMedCrossRefGoogle Scholar
  100. 100.
    Fitzgerald JF, Fagan LF, Tierney WM, Dittus RS (1987) Changing patterns of hip fracture care before and after implementation of the Prospective Payment System. JAMA 258: 218–221PubMedCrossRefGoogle Scholar
  101. 101.
    Fitzgerald JF, Moore PS, Dittus RS (1988) The care of elderly patients with hip fracture. Changes since implementation of the Prospective Payment System. N Engl J Med 319: 1392–1397PubMedCrossRefGoogle Scholar
  102. 102.
    Phillips S, Fox N, Jacobs J, Wright WE (1988) The direct medical costs of osteoporosis for American women aged 45 and older, 1986. Bone 9: 271–279PubMedCrossRefGoogle Scholar
  103. 103.
    Holbrook TL, Grazier K, Kelsey JL, Stauffer RN (1984) The frequency of occurrence, impact, and cost of selected musculoskeletal conditions in the United States. American Academy of Orthopaedic Surgeons, ChicagoGoogle Scholar
  104. 104.
    Peck WA, Riggs BL, Bell NH et al (1988) Research directions in osteoporosis. Am J Med 84: 275–282PubMedCrossRefGoogle Scholar
  105. 105.
    Praemer A, Furner S, Rice DP (1992) Musculoskeletal conditions in the United States. American Academy of Orthopaedic Surgeons, Park RidgeGoogle Scholar
  106. 106.
    Marotolli RA, Berkman LF, Cooney LM (1992) Decline in physical function following hip fracture. J Am Geriatr Soc 40: 861–866Google Scholar
  107. 107.
    Cummings SR, Phillips SL, Wheat ME et al (1988) Recovery of function after hip fracture. J Am Geriatr Soc 36: 801–806PubMedGoogle Scholar
  108. 108.
    Magaziner J, Simonsick EM, Kashner TM, Hebel JR, Kenzora JE (1990) Predictors of functional recovery one year following hospital discharge for hip fracture: a prospective study. J Gerontol Med Sci 45: M101 - M107Google Scholar
  109. 109.
    Mossey JM, Mutran E, Knott K, Craik R (1989) Determinants of recovery 12 months after hip fracture: the importance of psychosocial factors.Am J Public Health 79: 279–285Google Scholar
  110. 110.
    Ceder L, Thorngren K-G, Walden B (1980) Prognostic indicators and early home rehabilitation in elderly patients with hip fractures. Clin Orthop Rel Res 287: 173–184Google Scholar
  111. 111.
    Jalovaara P, Virkkunen H (1991) Quality of life after hemiarthroplasty for femoral neck fracture. Acta Orthop Scand 62: 208–217PubMedCrossRefGoogle Scholar
  112. 112.
    Versluysen M (1986) How elderly patients with femoral fracture develop pressure sores in hospital. BMJ 292: 1311–1313PubMedCrossRefGoogle Scholar
  113. 113.
    Huang C, Ross PD, Wasnich RD (1996) Vertebral fractures and other predictors of back pain among older women. J Bone Miner Res 11 (7): 1025–1031Google Scholar
  114. 114.
    Lyritis GP, Mayasis B, Tsakalakos N, Lambropoulos A, Gazi S, Karachalios TH, Tsekoura M, Yiatzides A (1989) The natural history of the osteoporotic vertebral fracture. Clin Rheumatol 8 [Supp12]: 66–69PubMedCrossRefGoogle Scholar
  115. 115.
    Gold DT (1996) The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone 18 [Suppl]: 185S - 189SPubMedCrossRefGoogle Scholar
  116. 116.
    Hallal J (1991) Back pain with postmenopausal osteoporosis and vertebral fractures. Geriatr Nurs 7: 285–287CrossRefGoogle Scholar
  117. 117.
    Sato K (1984) Spinal deformity and back pain in spinal osteoporosis. Jpn J Geriatr 21: 303–306Google Scholar
  118. 118.
    Silverman SL (1992) The clinical consequences of vertebral compression fracture. Bone 13 [Suppl]: S27 - S31PubMedCrossRefGoogle Scholar
  119. 119.
    Patel U, Skingle S, Campbell GA, Crisp AJ, Boyle IT (1991) Clinical profile of acute vertebral compression fractures in osteoporosis. Br J Rheumatol 30: 418–421PubMedCrossRefGoogle Scholar
  120. 120.
    Ryan PJ, Evans P, Gibson T, Fogelman I (1992) Osteoporosis and chronic back pain: a study with single-photon emission computed tomography bone scintigraphy. J Bone Miner Res 7 (12): 1455–1460PubMedCrossRefGoogle Scholar
  121. 121.
    Ryan PJ, Blake G, Herd R, Fogelman I (1994) A clinical profile of back pain and disability in patients with spinal osteoporosis. Bone 15: 27–30PubMedCrossRefGoogle Scholar
  122. 122.
    Leidig G, Minne HW, Sauer P, Wuster C, Wuster J, Lojen M, Raue F, Ziegler R (1990) A study of complaints and their relation to vertebral destruction in patients with osteoporosis. Bone Miner 8: 217–229PubMedCrossRefGoogle Scholar
  123. 123.
    Scane AC, Sutcliffe AM, Francis RM (1994) The sequelae of vertebral crush fractures in men. Osteoporosis Int 4: 89–92CrossRefGoogle Scholar
  124. 124.
    Raspe H-H (1993) Back pain. In: Silman AJ, Hochberg MC (eds) Epidemiology of the rheumatic diseases. Oxford University Press, New York, pp 330–374Google Scholar
  125. 125.
    Nevitt M, Ettinger B, Black D, Stone K, Genant H, Cummings S (1996) Functional impact of first and recurrent vertebral fracture: a prospective study. Osteoporosis Int 6 [Suppl 1]: 86CrossRefGoogle Scholar
  126. 126.
    Ross PD, Davis JW, Epstein RS, Wasnich RD (1994) Pain and disability associated with new vertebral fractures and other spinal conditions. J Clin Epidemiol 47: 231–239PubMedCrossRefGoogle Scholar
  127. 127.
    Lyles KW, Gold DT, Shipp KM, Pieper CF, Martinez S, Mulhausen PL (1993) Association of osteoporotic vertebral compression fractures with impaired functional status. Am J Med 94: 595–601PubMedCrossRefGoogle Scholar
  128. 128.
    Ettinger B, Block JE, Smith R, Cummings SR, Harris ST, Genant HK (1988) An examination of the association between vertebral deformities, physical disabilities, and psychosocial problems. Maturitas 10: 283–296PubMedCrossRefGoogle Scholar
  129. 129.
    Ettinger B, Black DM, Palermo L, Nevitt MC et al (1992) Contribution of vertebral deformities to chronic back pain and disability. J Bone Miner Res 7 (4): 449–456PubMedCrossRefGoogle Scholar
  130. 130.
    Itoi E, Sakurai M, Mizunashi K, Sato K, Kasama F (1990) Long-term observations of vertebral fractures in spinal osteoporosis. Calcif Tissue Int 47: 202–208PubMedCrossRefGoogle Scholar
  131. 131.
    Gold DT, Drezner MK (1995) Quality of life. In: Riggs BL, Melton LJ III (eds) Osteoporosis: etiology, diagnosis, and management, 2nd edn. Lippincott-Raven, PhiladelphiaGoogle Scholar
  132. 132.
    Huang C, Ross PD, Wasnich RD (1996) Vertebral fracture and other predictors of physical impairment and health care utilization. Arch Intern Med 156: 2469–2475PubMedCrossRefGoogle Scholar
  133. 133.
    Ross PD, Ettinger B, Davis JW, Melton LJ III, Wasnich RD (1991) Evaluation of adverse health outcomes associated with vertebral deformities. Osteoporosis Int 1 (3): 134–140CrossRefGoogle Scholar
  134. 134.
    Huang C, Ross PD, Davis JW, Wasnich RD (1996) Contributions of vertebral fractures to stature loss among elderly Japanese-American women in Hawaii. J Bone Miner Res 11 (3): 408–411PubMedCrossRefGoogle Scholar
  135. 135.
    Greendale GA, Barrett-Connor E, Ingles S, Haile R (1995) Late physical and functional effects of osteoporotic fracture in women: the Rancho Bernardo Study. J Am Geriatr Soc 43:955–961PubMedGoogle Scholar
  136. 136.
    Spector TD, McCloskey EV, Doyle DV, Kanis JA (1993) Prevalence of vertebral fracture in women and the relationship with bone density and symptoms: the Chingford Study. J Bone Miner Res 8 (7): 817–822PubMedCrossRefGoogle Scholar
  137. 137.
    Davies KM, Recker RR, Stegman MR, Heaney RP (1991) Tallness versus shrinkage: do women shrink with age or grow taller with recent birth date? J Bone Miner Res 6: 1115–1120PubMedCrossRefGoogle Scholar
  138. 138.
    Davies KM, Heaney RP, Ryan RR (1996) Height loss in older women (abstract). J Bone Miner Res 10 [Suppl 1]: S357Google Scholar
  139. 139.
    Liberman UA, Weiss SR, Broil J et al (1995) Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:1437–1443PubMedCrossRefGoogle Scholar
  140. 140.
    Kleerekoper M, Nelson DA, Peterson EL, Tilley BC (1992) Outcome variables in clinical trials. Bone 13 [Suppl 1]:S29–S34PubMedCrossRefGoogle Scholar
  141. 141.
    Leech JA, Dulberg C, Kellie S, Pattee L, Gay J (1990) Relationship of lung function to severity of osteoporosis in women. Am Rev Respir Dis 141 (1): 68–71PubMedGoogle Scholar
  142. 142.
    Xu L, Cummings SR, Qin MW, Stone K, Zhao XH, Chen XS, Jergas M, Richmond H, Nevitt MC, the Beijing Osteoporosis Project (1995) Vertebral osteoporosis in China: the first population-based study (abstract). J Bone Miner Res 10 [Suppl 1]:S467Google Scholar
  143. 143.
    Ensrud KE, Nevitt MC, Yunis C, Cauley JA, Seeley DG, Fox KM, Cummings SR (1994) Correlates of impaired function in older women. J Am Geriatr Soc 42: 481–489PubMedGoogle Scholar
  144. 144.
    Greendale GA, Barrett-Connor E (1996) Outcomes of osteoporotic fractures. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis. Academic, San Diego, pp 635–643Google Scholar
  145. 145.
    Cook DJ, Guyatt GH, Adachi JD et al (1993) Quality of life issues in women with vertebral fractures due to osteoporosis. Arthritis Rheum 36: 750–756PubMedCrossRefGoogle Scholar
  146. 146.
    Atkins RM, Duckworth T, Kanis JA (1990) Algodystrophy following Colles’ fracture. J Bone Joint Surg 72 B: 105–110Google Scholar
  147. 147.
    de Bruijn HP (1987) The Colles’ fracture, review of literature, chap 3. Acta Octhop Scand 58 [Suppl 223]: 7–25Google Scholar
  148. 148.
    Kaukonen J-P, Karaharju EO, Porras M, Luthje P, Jakobsson A (1988) Functional recovery after fractures of the distal forearm. Ann Chir Gynacol 77: 27–31Google Scholar
  149. 149.
    Chrischilles EA, Butler CD, Davis CS, Wallace RB (1991) A model of lifetime osteoporosis impact. Arch Intern Med 151: 2026–2032PubMedCrossRefGoogle Scholar
  150. 150.
    Theintz G, Buchs B, Rizzoli R et al (1992) Longitudinal monitoring of bone mass accumulation in healthy adolescents: Evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab 75: 1060–1065PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1998

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  • P. D. Ross

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