Abstract
The word “clone” is used to describe a cell population that has derived from a single cell. Such single cells are termed “clonogenic” and only a small proportion of normal cells and probably a higher proportion of tumor cells have the proliferative capabilities required to give rise to clones. Both normal and neoplastic stem cells may be considered clonogenic as they have the ability to renew themselves and produce descendants which differentiate.
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Heenan M, O’Driscoll L, Cleary I, Connolly L, Clynes M (1997) Isolation and characterisation of multiple clonal subpopulations of an MDR human lung cell line which exhibits significantly different levels of resistance. Int J Cancer 71: 907–915
Meliolo G, Ratto G, Guastella M, Meta M, Biassoni R, Semino C, Casartelli G, Pasquetti W, Catrullo A, Moretta L (1994) Isolation and in vitro expansion of lymphocytes infiltrating non-small cell lung carcinoma: functional and molecular characterisation for their use in adoptive immunotherapy. Eur J Cancer 30A: 97–102
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© 1998 Springer-Verlag Berlin Heidelberg
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McBride, S., Heenan, M., Clynes, M. (1998). Cloning Animal Cells. In: Clynes, M. (eds) Animal Cell Culture Techniques. Springer Lab Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80412-0_1
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DOI: https://doi.org/10.1007/978-3-642-80412-0_1
Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-642-80412-0
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