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Abstract

Thoracic cancers are among the most common encountered by oncologists. Lung cancer continues to be a major health problem worldwide. In 1994, 172000 lung cancers were diagnosed in the United States, with 153000 deaths, and the incidence has been increasing in women [1]. It is now the second most lethal cancer in the world [9]. Non-small-cell lung carcinoma (NSCLC) accounts for about 75% of all lung cancers. Small-cell lung carcinoma (SCLC) generally has distant metastasis at the time of presentation and entails a 5 year-survival rate after surgical resection of less than 1% [9]. NSCLC has the potential for surgical cure if detected prior to metastases. The 5-year survival rate in stage No (no nodal metastasis) is 46%, in stage Ni (hilar nodes only) 33%, and in stage N2 (mediastinal nodes involved) only 8% [10]. The strongest prognostic factor for survival is whether complete resection is possible.

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References

  1. American Cancer Society (1994) Cancer facts and figures.

    Google Scholar 

  2. Bay-Shalom R, Israel O, Haim N, Levior M, Epelbaum R, Frenkel A, Ben-Haim S, Kolodny GN, Front D (1996) Diffuse lung uptake of Ga-67 after treatment of lymphoma. Radiology 199:473–476

    Google Scholar 

  3. Gambhir SS, Gupta P, Allen P, Hoh C, Maddahi J, Phelps ME (1996) A simulation tool for modeling cost effectiveness with applications for determing the cost effective role of nuclear medicine studies in lung and breast cancer. J Nucl Med 37:1428–1434

    PubMed  CAS  Google Scholar 

  4. Hisada K, Tonami N, Miyamae T, Hiraki Y, Yamazaki T, Maeda T, Nakajo N (1978) Clinical evaluation of tumor imaging with Tl-201 chloride. Radiology 129:497–500

    PubMed  CAS  Google Scholar 

  5. Inoue T, Kim EE, Komaki R, Wong FCL, Bassa P, Wong W-H, Yang DJ, Endo K, Podoloff DA (1995) Detecting recurrent or residual lung cancer with FDG-PET. J Nucl Med 36:788–793

    PubMed  CAS  Google Scholar 

  6. Kaplan LD, Wofsy RB, Volberding PA (1987) Treatment of patients with acquired immunodeficiency syndrome and associated manifestations. JAMA 257:1367–1374

    Article  PubMed  CAS  Google Scholar 

  7. Kaplan WD, Jochelson MS, Herman TS (1990) Ga-67 imaging: a predictor of residual tumor viability and clinical outcome in patients with diffuse large-cell lymphoma. J Clin Oncol 8:1966–1970

    PubMed  CAS  Google Scholar 

  8. King SC, Reiman RJ, Prosnitz LR (1994) Prognostic importance of restaging gallium scans following induction chemotherapy for advanced Hodgkin’s disease. J Clin Oncol 12:306–311

    PubMed  CAS  Google Scholar 

  9. Ginsberg RJ, Vokes EE, Raben A (1997) Non-small cell lung cancer. In: DeVita VT Jr, Heilman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott-Raven, Philadelphia, pp 858–910

    Google Scholar 

  10. Mountain CF (1989) Value of the new TNM staging system of lung cancer. Chest 96:47s

    Google Scholar 

  11. Patz EJ Jr, Lowe VJ, Hoffman JN, Paine SS, Harris LK, Goodman PC (1994) Persistent or recurrent bronchogenic carcinoma: detection with PET and F-18 2-deoxy-D-glucose. Radiology 191:379–382

    PubMed  Google Scholar 

  12. Stokkel MP, Pauwels EK (1994) Octreotide scintigraphy for small cell lung carcinoma. Eur J Nucl Med 21:1276–1278

    Article  PubMed  CAS  Google Scholar 

  13. Waxman AD (1986) The role of nuclear medicine in pulmonary neoplastic processes. Semin Nucl Med 16:285–295

    Article  PubMed  CAS  Google Scholar 

  14. Webb WR, Gatsonis C, Zerhourni EA (1991) CT and MR in staging non-small bronchogenic carcinoma: report of the Radiological Diagnostic Oncology Group. Radiology 178:705–713

    PubMed  CAS  Google Scholar 

  15. Woolfenden JM, Carrasquillo JA, Larson SM (1987) Acquired immunodeficiency syndrome: Ga-67 citrate imaging. Radiology 162:383–387

    PubMed  CAS  Google Scholar 

References

  1. Tonami N, Shuke N, Kunihilo Y, Seki H, Takayama T, Kinuya S, Nakajima K, Aburano T, Hisada K (1989) Use of thallium-201 single photon emission computed tomography in the evaluation of suspected lung cancer. J Nucl Med 30:997–1004

    PubMed  CAS  Google Scholar 

  2. Lee J, Ahn BC, Kim CH et al (1986) Can Tl-201 SPECT indeed differentiate a benign and malignant solitary pulmonary lesion? J Nucl Med 37:268P (abstract)

    Google Scholar 

  3. Lee JD, Lee BH, Kim SK, Chung KY, Shin DH, Park CY (1994) Increased thallium-201 uptake in collapsed lung: a pitfall in scintigraphic evaluation of central bronchogenic carcinoma. J Nucl Med 35:1125–1128

    PubMed  CAS  Google Scholar 

  4. Tonami N, Yokoyama K, Taki J et al (1990) Tissue characterization of suspected malignant pulmonary lesion with Tl-201 SPECT. J Nucl Med 31:766 (abstract)

    Google Scholar 

  5. Tonami N, Yokoyama K, Shuke N et al (1993) Evaluation of suspected malignant pulmonary lesions with thallium-201 SPECT. J Nucl Med 34(S):139P (abstract)

    Google Scholar 

  6. Duman Y, Burak Z, Erdem S et al (1990) The value and limitations of Tl-201 scintigraphy in the evaluation of lung lesions and post-therapy follow-up of primary lung carcinoma. Nucl Med Commun 14:446–453

    Article  Google Scholar 

  7. Hassan I, Sahweel C, Constantinides A et al (1989) Uptake and kinetics of Tc-99m hexakis 2-methoxy isobutyl isonitrile in benign and malignant lesions in the lungs. Clin Nucl Med 14:333–340

    Article  PubMed  CAS  Google Scholar 

  8. Muller SP, Reiners C, Pass M et al (1989) Tc-99m MIBI and Tl-201 uptake in bronchial carcinoma. J Nucl Med 30:845 (abstract)

    Google Scholar 

  9. Lebouthillier G, Taillefer R, Lambert R et al (1993) Detection of primary lung cancer with Tc-99m MIBI. J Nucl Med 34:140P (abstract)

    Google Scholar 

  10. Onsel C, Sonmezoglu K, Camsari G et al (1996) Technetium-99m MIBI scintigraphy in pulmonary tuberculosis. J Nucl Med 37:233–238

    PubMed  CAS  Google Scholar 

  11. Rageb A, Elgazzar AH, Ibrahim AK et al (1993) A comparative study between planar Ga-67, Tl-201, chest x-ray and x-ray CT scans in inoperable non-small cell carcinoma of the lung. Eur J Nucl Med 20:838 (abstract)

    Google Scholar 

  12. Itoh K, Takekawa H, Tsukamoto E et al (1992) Single photon emission computed tomography using Tl-201 chloride in pulmonary nodules: comparison with Ga-67 citrate and Tc-99m-labeled hexamethylpropyleneamine-oxime. Ann Nucl Med 6:253–260

    Article  PubMed  CAS  Google Scholar 

  13. Hirano T, Otake H, Yoshida I, Endo K (1995) Primary lung cancer SPECT imaging with pentavalent technetium-99m DMSA. J Nucl Med 36:202–207

    PubMed  CAS  Google Scholar 

  14. Lee J, Ahn BC, Kim CH et al (1996) Prospective comparison of Tl-201, Tc-99m MIBI and Tc-99m-(V)-DMSA in the same subjects with a solitary pulmonary lesion. J Nucl Med 37(s):267P (abstract)

    Google Scholar 

  15. Alazraki NP, Ramsdel JW, Talylor A et al (1978) Reliability of gallium scan, chest radiography compared to mediastinoscopy for evaluating mediastinal spread in lung cancer. Am Rev Respir Dis 117:415–420

    PubMed  CAS  Google Scholar 

  16. Fosburg RG, Hopkins GB, Kan MK (1979) Evaluation of the mediastinum by Ga-67 scintigraphy in lung cancer. J Thorac Cardiovasc Surg 77:76–82

    PubMed  CAS  Google Scholar 

  17. Lesk DM, Wood TE, Carrol SE, Reese L (1978) The application of Ga-67 scanning in determining the operability of bronchogenic carcinoma. Radiology 128:707–709

    PubMed  CAS  Google Scholar 

  18. McKenna RJ, Haynie TP, Libshitz HI et al (1985) Critical evaluation of the Ga-67 scan for surgical patients with lung cancer. Chest 87:428–431

    Article  PubMed  Google Scholar 

  19. Waxman AD, Goldsmith MS, Greif PM et al (1987) Differentiation of tumor versus sarcoidosis using thallium-201 in patients with hilar mediastinal adenopathy (abstract). J Nucl Med 28:561

    Google Scholar 

  20. Matsuno S, Tanabe M, Kawasaki Y et al (1992) Effectiveness of planar image and single photon emission tomography of thallium-201 compared with gallium-67 in patients with primary lung cancer. Eur J Nucl Med 19:86–95

    Article  PubMed  CAS  Google Scholar 

  21. Chiti A, Maffioli LS, Infante M et al (1996) Assessment of mediastinal involvement in lung cancer with technetium-99m-sestamibi SPECT. J Nucl Med 37:938–942

    PubMed  CAS  Google Scholar 

  22. Krenning EP, Kwekkeboom DJ, Reubi JC, Lamberts SW (1994) Somatostatin receptor scintigraphy with [In-111-DTPA-D-Phei] octreotide. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment. Churchill Livingston, New York, pp 757–764

    Google Scholar 

  23. Orsolon P, Bagni B, Basadonna P, Geatti O, Talmassons G, Guerra -UP (1995) A case of bronchial carcinoid: diagnosis and follow-up with In-111-DTPA-octreotide. Q J Nucl Med 39:311–314

    PubMed  CAS  Google Scholar 

  24. Miyagawa M, Watanabe K, Shiode M et al (1993) Tl-201 SPECT in the follow-up of patients with lung cancer during radiotherapy. J Nucl Med 34:222P (abstract)

    Google Scholar 

  25. Bom HS, Song HC, Kim JY et al (1994) The usefulness of Tc-99m MIBI SPECT in the localization and the assessment of radiotherapy in non-small cell lung cancer. Kor J Nucl Med 28:186–191

    Google Scholar 

  26. Ihde DC (1992) Chemotherapy of drug cancer. N Engl J Med 12:1434–1441

    Google Scholar 

  27. Deuchars KL, Ling V (1989) P-glycoprotein and multidrug resistance in cancer chemotherapy. Semin Oncol 16:156–165

    PubMed  CAS  Google Scholar 

  28. Piwnica-Worms D, Chiu ML, Budding J, Kornauge JF, Kramer RA, Croop JM (1993) Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res 53:977–984

    PubMed  CAS  Google Scholar 

  29. Moretti JL, Cagler M, Boaziz C, Caillat-Vigneron N, Morere JF (1995) Sequential functional with technetium-99m hexakis-2-methoxyisobutylisonitrile and indium-111 octreotide: can we predict the response to chemotherapy in small cell lung cancer? Eur J Nucl Med 22:177–180

    Article  PubMed  CAS  Google Scholar 

  30. Bom HS, Kim YC, Song HC, Kim JY, Park KO (1996) Tc-99m sestamibi uptake in small cell lung cancer: A predictor of response to chemotherapy. J Nucl Med 37:67P (abstract)

    Google Scholar 

  31. Miller AB, Hoogstraten B, Staquet M, Winkler A (1981) Reporting results of cancer treatment. Cancer 47:207–214

    Article  PubMed  CAS  Google Scholar 

  32. Waxman AD (1996) Thallium-201 and technetium-99m methoxyisobutyl isonitrile (MIBI) in nuclear oncology. In: Sandler MP, Coleman RE, Wackers FJT, Patton JA, Gottschalk A, Hoffer PB (eds) Diagnostic nuclear medicine, 3rd edn. Williams and Wilkins, Baltimore, pp 1261–1274

    Google Scholar 

  33. Scopinaro F, Schillaci O, Scarpini M et al (1994) Technetium-99m sestamibi: an indicator of breast cancer invasiveness. Eur J Nucl Med 21:984–987

    Article  PubMed  CAS  Google Scholar 

  34. Harris AL, Hochhauser D (1992) Mechanisms of multidrug resistance in cancer treatment. Acta Oncol 31:205–213

    Article  PubMed  CAS  Google Scholar 

  35. Crankshaw C, Piwnica-Worms D (1996) Tc-99m sestamibi may be a transport substrate of the human multidrug resistance-associated protein (MRP). J Nucl Med 37:247P (abstract)

    Google Scholar 

  36. Kapucu CO, Akyuz C, Vural G et al (1996) The value of MIBI scintigraphy in predicting the prognosis in pediatric patients with lymphoma. J Nucl Med 37:139P (abstract)

    Google Scholar 

  37. Piwnica-Worms D, Rao VV, Kronauge JF, Croop JM (1995) Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation. Biochemistry 34:12210–12220

    Article  PubMed  CAS  Google Scholar 

  38. Yamamoto Y, Nishiyama Y, Fukynaga K, Satoh K, Takashima H, Tanabe M (1996) Evaluation of Tc-99m MIBI to predict chemotherapeutic response of patients with small cell lung cancer. Ann Nucl Med 10 [Suppl]:S137 (abstract)

    Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Kim, E.E. (1998). Lung Cancer. In: Nuclear Imaging of the Chest. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80387-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-80387-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80389-5

  • Online ISBN: 978-3-642-80387-1

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