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Quinolone Antibacterials pp 13–62Cite as

The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 127))

Abstract

The quinolones, similar to the sulfonamides and nitrofurans, are totally synthetic chemical compounds used to combat infections (Albrecht 1977). They are derived by substitution of 1,4-dihydro-4-oxo-quinoline-3-carboxylic acids (structural formula 1) at the nitrogen atom of position 1.

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Authors
  1. K. Grohe
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Editors and Affiliations

  1. Bayer AG Geschäftsbereich Pharma Pharma-Forschungszentrum, Institut für Klinische Pharmakologie, Geb. 429, D-42096, Wuppertal, Germany

    J. Kuhlmann

  2. Institut für Medizinische Mikrobiologie und Virologie, Christian-Albrechts-Universität, D-24105, Brunswiker Str. 4, Kiel, Germany

    A. Dalhoff

  3. Bayer AG Geschäftsbereich Pharma Pharma-Forschungszentrum, Institut für Chemotherapie, Geb. 405, D-42096, Wuppertal, Germany

    H.-J. Zeiler

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© 1998 Springer-Verlag Berlin Heidelberg

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Grohe, K. (1998). The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System. In: Kuhlmann, J., Dalhoff, A., Zeiler, HJ. (eds) Quinolone Antibacterials. Handbook of Experimental Pharmacology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80364-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-80364-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80366-6

  • Online ISBN: 978-3-642-80364-2

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