Abstract
Lesher et al. (1962) showed that 7-chloro-1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylic acid, referred to as compound (a), which was obtained as an impurity during the manufacture of chloroquine, possessed antibacterial activity.
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References
Albrecht R (1977) Development of antibacterial agents of the nalidixic type. Prog Drug Res 21:9–104
Bergan T, Williams JD (1982) Dose-dependence of piperacillin pharmacokinetics. Chemotherapy 28:153–159
Bergan T, Thornsteinsson SB, Steingrimsson O (1982) Dose-dependent pharmacokinetics of azlocillin compared to mezlocillin. Chemotherapy 28:160–170
Chao L (1978) An unusual interaction between the target of nalidixic acid and novobiocin. Nature 271:385–386
Crumplin GC, Smith JT (1975) Nalidixic acid, an antibacterial paradox. Antimicrob Agents Chemother 8:251–261
Dalhoff A (1994) Activities of ciprofloxacin and sparfloxacin against strept. pneumoniae (Abstr 34). 5th International Congress on New Quinolones, Singapore, p 43
Domagala JM (1994) Structure-activity and structure side-effect relationships for the quinolone antibacterials. J Antimicrob Chemother 33:685–706
Gerster JF (1973) DOS 2 264 163. Substituted benzo[ij]quinazoline-2-carboxylic acids and their derivatives, Riker Laboratories, Northridge. Chem Abstr 79:92029y
Hokuriku Pharmaceutical (Japan) (1986) NY — 198. Drugs Future 11:578–579
Holden HE, Barrett JF, Huntington CM, Muehlbauer PA, Wahrenburg MG (1989) Genetic profile of nalidixic acid analog: a model for the mechanism of sister chromatid exchange induction. Environ Mol Mutag 13:238–252
Hooper DC, Wolfson JS (1993) Adverse effects. In: Hooper DC, Wolfson JS (eds) Quinolone antimicrobial agents, 2nd edn. American Society of Microbiology, Washington, pp 489–512
Howard BMA, Pinney RJ, Smith JT (1993) 4-quinolone bactericidal mechanisms. Arzneimittelforschung 43:1125–1129
Lesher GY, Carabateas PM (1972) DOS 2224090. l-Alkyl-l,4-dihydro-4-oxo-3-quinolonecarboxylic acids and esters
Lesher GY, Carabateas PM (1973) l-Alklyl-l,4-dihydro-4-oxo-3-quniolonecarboxylic acids and esters. Sterling Drug Inc. (C.A. 78, 84280 n (1973))
Lesher GY, Froelich EJ, Gruett MD, Bailey JH, Brundage RP (1962) 1,8- naphthyridine derivatives, a new class of chemotherapy agents. J Med Chem 5:1063–1065
Lewin CS (1992) Antibacterial activity of a 1,8-naphthyridine quinolone, PD 131628. J Med Microbiol 36:353–357
Lewin CS, Amyes SGB (1989) The bactericidal activity of DR-3355, an optically active isomer of ofloxacin. J Med Microbiol 30:227–231
Lewin CS, Amyes SGB (1990a) Conditions required for the bactericidal activity of fleroxacin and pefloxacin against Escherichia coli KL 16. J Med Microbiol 32:83–86
Lewin CS, Amyes SGB (1990b) Bactericidal action of PD 127391, an enhanced spectrum quinolone. J Med Microbiol 33:67–70
Lewin CS, Smith JT (1988) Bactericidal mechanisms of ofloxacin. J Antimicrob Chemother [Suppl C] 22:1–8
Lewin CS, Smith JT (1989) Interactions of 4-quinolones with other antibacterials. J Med Microbiol 29:221–227
Lewin CS, Smith JT (1990) Conditions requried for the bactericidal activity of 4- quinolones against Serratia marcescens. J Med Microbiol 32:211–214
Lewin CS, Amyes SGB, Smith JT (1989) Bactericidal activity of enoxacin and lomefloxacin against Escherischia coli K16. Eur J Clin Microbiol 8:731–733
Lewin CS, Howard BMA, Smith JT (1991a) 4-quinolone interactions with gyrase B subunit inhibitors. J Med Microbiol 35:358–362
Lewin CS, Morrissey I, Smith JT (1991b) The mode of action of quinolones: the paradox in activity of low and high concentrations and activity in the anaerobic environment. Eur J Clin Microbiol 10:240–248
Lewin CS, Morrissey I, Smith JT (1991c) The fluoroquinolones exert a reduced rate of kill against Enterococcus faecalis. J Pharm Pharmacol 43:492–494
Lewin CS, Howard BMA, Smith JT (1991d) Protein-and RNA-synthesis independent bactericidal activity of ciprofloxacin that involves the A subunit of DNA gyrase. J Med Microbiol 34:19–22
Lewin CS, Morrissey I, Smith JT (1992) The bactericidal activity of Sparfloxacin. J Antimicrob Chemother 30:625–632
Mates SM, Patel L, Karback HR, Miller MH (1983) Membrane potential in anaerobi- cally growing Staphylococcus aureus and its relationship with gentamicin uptake. Antimicrob Agents Chemother 23:526–530
Matsumoto J, Minami S (1975) Pyrido[2,3-d]pyrimidine antibacterial agents. 3. 18-alkyl- and 8-vinyl-5,8-dihydro-5-oxo-2-(l-piperazinyl)pyrido[2,3-d]pyrimidine- 6-carboxylic acids and their derivatives. J Med Chem 18:74–79
Mitcher LA, Devasthale P, Zavod R (1993) Structure-activity relationships. In: Hooper DC, Wolfson JS (eds) Quinolone antimicrobial agents, 2nd edn. American Society of Microbiology, Washington, pp 3–51
Morrissey I, Smith JT (1993a) Activity of quinolone antibacterials against Streptococcus pneumoniae. Drugs 45[Suppl 3]:196–197
Morrissey I, Smith JT (1993b) Effect of inoculum size on 4-quinolone uptake by Escherischia coli KL 16 (Abstr 19). J Pharm Pharmacol 45[Suppl 2]:1106
Morrissey I, Smith JT (1994) The activity of 4-quinolones against Pseudomonas aeruginosa. Arzneimittelforschung 44:1157–1161
Morrissey I, Lewin CS, Smith JT (1990) The influence of oxygen upon bactericidal potency. In: Crumplin GC (ed) The 4-quinolone antibacterial agents in vitro. Springer, Berlin Heidelberg New York, pp 23–36
Ratcliffe NT, Smith JT (1983) Effects of magnesium on the activity of 4-quinolone antibacterial agents. J Pharm Pharmacol 35:61P
Ratcliffe NT, Smith JT (1985a) Ciprofloxacin’s bactericidal and inhibitory actions in urine. Chemotherapia 4[Suppl 2]:385–386
Ratcliffe NT, Smith JT (1985b) Norfloxacin has a novel bactericidal mechanism unrelated to that of other 4-quinolones. J Pharm Pharmacol 37[Suppl]:92P
Rohwedder RW, Bergan T, Thorsteinsson SB, Scholl H (1990) Transintestinal elimination of ciprofloxacin. Diagn Microbiol Infect Dis 13:127–133
Ryley JF, Peters W (1970) The antimalarial activity of some quinolone esters. Ann Trop Med Parasitol 64:209–222
Sarma PS (1989) Norfloxacin a new drug in the treatment of falciparum malaria. Ann Intern Med 3:336–337
Schentag JJ (1982) Aminoglycosides. In: Evans WE, Schentag JJ, Jusko WJ (eds) Applied pharmacokinetics; principles of therapeutic drug monitoring. Applied Therapeutics, San Francisco, pp 174–209
Scully BE, Parry MF, Neu HC, Mandell W (1986) Oral ciprofloxacin therapy of infections due to Pseudomonas aeruginosa. Lancet 2:819–822
Shen LL, Baranowski J, Pernet AG (1989) Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA. Biochemistry 28:3879–3885
Smith JT (1984) Awakening the slumbering potential of the 4-quinolone antibacterials. Pharm J 233:299–305
Smith JT (1990) Mutation rates to 4-quinolones resistance. Arzneimittelforschung 40:65–68
Smith JT (1991) Ofloxacin, a bactericidal antibacterial. Chemotherapy 37 [Suppl 1]:2–13
Smith JT, Lewin CS (1988) Chemistry and mechanisms of action of the quinolone antibacterials. In: Andriole VT (ed) The quinolones. Academic, London, pp 23–82
Wiedemann B, Rustige-Wiedeman C, Kratz B (1994) Comparison of the pharmacodynamic properties of quinolones (Abstr 67). 5th International Congress on New Quinolones, Singapore, p 84
Zeiler H-J, Grohe K (1984) The in vitro and in vivo activity of ciprofloxacin. Eur J Clin Microbial 3:339–343
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Smith, J.T., Zeiler, HJ. (1998). History and Introduction. In: Kuhlmann, J., Dalhoff, A., Zeiler, HJ. (eds) Quinolone Antibacterials. Handbook of Experimental Pharmacology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80364-2_1
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DOI: https://doi.org/10.1007/978-3-642-80364-2_1
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