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Molekularbiologie, Klinik und Therapie steroidbedingter Hypertonien

  • Chapter
Herz-Kreislauf-Erkrankungen

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 3))

Zusammenfassung

Steroidbedingte Hypertonien repräsentieren nach den renalen Erkrankungen die häufigste Ursache der sekundären Hypertonie. Steroidhormone werden unterteilt in Glukokortikoide, Mineralokortikoide und Sexualsteroide. Die endogenen Glukokortikoide sind nicht selektiv und können auch mineralokortikoide Wirkungen aufweisen. Die Mehrzahl endogener Steroidhypertonien wird durch Nebennieren-oder Hypophysentumoren ausgelöst (Cushing-Syndrom, primärer Hyperaldosteronismus). In anderen Fällen steroidbedingter Hypertonie liegen isolierte Gendefekte im Steroidmetabolismus vor (Tabelle 4.4.1). Diese Defekte machen sich meist schon im Kindesalter bemerkbar und sollten früh diagnostiziert und spezifisch therapiert werden. Die Klassifizierung der Hypertonie im Kindesalter ist allerdings noch unklar, und es ist zu berücksichtigen, daß die Normwerte des Blutdrucks bei Kindern niedriger liegen, als bei Erwachsenen [Joint National Committee 1988].

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Peters, J., Hampf, M., Peters, B., Bernhardt, R. (1998). Molekularbiologie, Klinik und Therapie steroidbedingter Hypertonien. In: Ganten, D., Ruckpaul, K. (eds) Herz-Kreislauf-Erkrankungen. Handbuch der Molekularen Medizin, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80360-4_13

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