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Bedeutung peptiderger Systeme bei der Genese kardiovaskulärer Erkrankungen

  • Chapter
Herz-Kreislauf-Erkrankungen

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 3))

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Zusammenfassung

Peptide, wie die Angiotensine, Kinine, Endotheline und die natriuretischen Peptide, sind die wichtigsten Regulatorsubstanzen im Herz-Kreislauf-System. Da kardiovaskuläre Regulationsvorgänge meist relativ langsame Prozesse sind, die Minuten bis Tage dauern können, sind Peptide geeignete Transmittersubstanzen, während sie für neuronale Prozesse, die in Bruchteilen von Sekunden ablaufen, weniger brauchbar erscheinen. Die in jenem System wirkenden Neurotransmitter, wie Noradrenalin, Dopamin, Serotonin, Glutamat und Glyzin, können in Zellen mit Hilfe von effizienten Enzymkaskaden in großer Menge hergestellt, in Vesikeln gespeichert und durch Stimuli angeregt schnell freigesetzt werden. Aus dem Extrazellularraum werden sie durch Transportproteine oder abbauende Enzyme ebenso schnell wieder entfernt. Somit ist ihre Wirkung auf nachgeschaltete Zellen räumlich und zeitlich begrenzt und dadurch in der Regel auf den synaptischen Spalt zwischen 2 Neuronen beschränkt.

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Stula, M., Schott, E., Paul, M. (1998). Bedeutung peptiderger Systeme bei der Genese kardiovaskulärer Erkrankungen. In: Ganten, D., Ruckpaul, K. (eds) Herz-Kreislauf-Erkrankungen. Handbuch der Molekularen Medizin, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80360-4_11

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