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The Value of Animal Assays and the Quenching Phenomenon

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Fragrances

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Abstract

In the absence of in vitro models for the identification of skin sensitizers and for estimation of their potency, animal models still provide the foundation for risk assessment in this area of toxicology. In this chapter, the most commonly used models are briefly described, particularly with respect to their use in defining the potency of a particular skin sensitizer. The important points are demonstrated by a consideration of sensitizing fragrance ingredients and the quenching phenomenon.

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Authors
  1. D. Basketter
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Editor information

Editors and Affiliations

  1. Städtische Kliniken Dortmund, Hautklinik and Department of Dermatology, University of Witten/Herdecke, Beurhausstraße 40, D-44137, Dortmund, Germany

    Peter J. Frosch

  2. Gentofte Hospital, Department of Dermatology, University of Copenhagen, Niels Andersen Vej 65, DK-2900, Hellerup, Denmark

    Jeanne Duus Johansen

  3. St. John’s Institute of Dermatology, St. Thomas’ Hospital, SEI 7EH, London, England

    Ian R. White

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© 1998 Springer-Verlag Berlin Heidelberg

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Basketter, D. (1998). The Value of Animal Assays and the Quenching Phenomenon. In: Frosch, P.J., Johansen, J.D., White, I.R. (eds) Fragrances. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80340-6_21

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  • DOI: https://doi.org/10.1007/978-3-642-80340-6_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80342-0

  • Online ISBN: 978-3-642-80340-6

  • eBook Packages: Springer Book Archive

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