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Fragrances pp 159-165 | Cite as

The Hydroxycitronellal Story: What Can We Learn from It?

  • R. R. Suskind
Conference paper

Abstract

What is the character and size of the database for this fragrance molecule? A computer review of the database — provided by A. M. Api of RIFM reveals 241 references in which the range of subjects includes animal studies, toxicity, diagnostic evaluation using patch tests, and safety assessment. These have been carried out over a period of almost 25 years. This compound, which is 7-hydroxy-3,7-dimethyloctan-1-al, is shown in Fig. 1. Between 1973 and 1980, 14 human maximization tests were carried out to determine the sensitizing potential of hydroxydtronellal. This is shown in Table 1.

Keywords

Patch Test Sensitization Reaction Diethyl Phthalate Positive Patch Test Fragrance Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Epstein W (1976) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  2. Epstein W (1978) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  3. Epstein W (1979) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  4. Epstein W (1980) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  5. Kligman A (1973) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  6. Kligman A (1976) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  7. Kligman A (1978) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  8. Kligman A (1979) Report to Research Institute for Fragrance Materials, Inc.Google Scholar
  9. Suskind RR (1992) Hydroxycitronellal. “The Whole and Final? Story”. Proceedings of the Sixth International Information Exchange of the Research Institute for Fragrance Materials. Princeton, New Jersey, 19–20 November, pp 75–83Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • R. R. Suskind

There are no affiliations available

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