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Transitional Cell Carcinoma, Bladder, Rat

  • Chapter
Urinary System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

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Abstract

The earliest transitional cell carcinoma (TCC) cannot be detected with the naked eye, but its presence and papillary appearance on the luminal surface of the urinary bladder can be easily visualized with a stereomicroscope. As the cauliflower-like tumors reach 1 cm or greater in diameter, areas of necrosis and hemorrhage may be present. Tumors are frequently multifocal, but may become confluent and grossly fill the lumen of the bladder. The texture of the mass varies from soft to firm, depending upon the amount of tissue present. Invasion of the subepithelial connective tissue and of the muscle layers may be visible upon dissection. Metastases may occur in paraaortic lymph nodes and the lungs, but they are rare.

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Authors
  1. Bendicht U. Pauli
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  2. Achim D. Gruber
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  3. Ronald S. Weinstein
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Editor information

Editors and Affiliations

  1. Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street,N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology Emeritus) (Professor of Comparative Pathology Emeritus)

  2. American Health Foundation, One Dana Drive, Valhalla, NY, USA

    Gordon C. Hard BVSc., Ph.D., DSc., FRCPath., FRCVS, FAToxSci. (Director of Administration and Senior Toxicologist) (Director of Administration and Senior Toxicologist)

  3. Medizinische Hochschule Hannover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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© 1998 Springer-Verlag Berlin Heidelberg

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Pauli, B.U., Gruber, A.D., Weinstein, R.S. (1998). Transitional Cell Carcinoma, Bladder, Rat. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_37

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  • DOI: https://doi.org/10.1007/978-3-642-80335-2_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80337-6

  • Online ISBN: 978-3-642-80335-2

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