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Ökosystem Darm VII pp 187–201Cite as

Intraepitheliale Lymphozyten: Die erste Garde einer Immunabwehr?

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Zusammenfassung

Die Funktionen intraepithelialer Lymphozyten (IEL) sind weitgehend unge-klärt. Aufgrund ihrer Lokalisation in der Darmmukosa wird postuliert, daß IEL die erste Garde einer Immunabwehr bilden. Da sie die ersten Immunzellen sind, die mit potentiell gefährlichen Antigenen, wie z.B. invasiven Mikroorganismen in Kontakt treten, ist davon auszugehen, daß diese Zellpopulation entscheidend an der Initiierung einer Immunabwehr beteiligt ist. Bislang ist jedoch nur sehr wenig darüber bekannt, wie IEL ihre vermeintliche Rolle als Wächter des Epithels wahrnehmen könnten. IEL sind von der Lamina propria nur durch die Basalmembran getrennt. Es wäre daher vorstellbar, daß IEL durch die Sekretion von Botenstoffen (Zytokinen) Kontakt mit den Immunzellen der Lamina propria aufnehmen und diese zur Immunabwehr rekrutieren (s. Abb. 1). Weiterhin würde es der direkte Kontakt zu den Epithelzellen erlauben, daß transformierte bzw. infizierte Epithelzellen eliminiert werden und IEL somit auch an der Aufrechterhaltung und Integrität der Epithelschicht beteiligt sind.

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Authors
  1. W. Holtmeier
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Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie und Hygiene, Albert-Ludwigs-Universität, Hermann-Herder-Straße 11, D-79104, Freiburg i. Br., Germany

    Prof. Dr. med. Manfred Kist

  2. Schwerpunkte: Gastroenterologie/Hepatologie und Pneumologie/Allergologie, Medizinische Klinik, Universitätsklinikum, Theodor-Stern-Kai 7, D-60590, Frankfurt a.M., Germany

    Prof. Dr. med. Wolfgang F. Caspary

  3. Zentrum für Kinderheilkunde, Rheinische Friedrich-Wilhelms-Universität, Adenauerallee 119, D-53113, Bonn, Germany

    Prof. Dr. med. Michael J. Lentze

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Holtmeier, W. (1996). Intraepitheliale Lymphozyten: Die erste Garde einer Immunabwehr?. In: Kist, M., Caspary, W.F., Lentze, M.J. (eds) Ökosystem Darm VII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80327-7_16

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  • DOI: https://doi.org/10.1007/978-3-642-80327-7_16

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