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Chronic Pancreatitis: Treatment

  • Chapter
Pancreatitis

Abstract

Although pain is the most common symptom of chronic pancreatitis, there are no specific features which easily distinguish pain caused by pancreatitis from that caused by other abdominal conditions. The cause of abdominal pain in chronic pancreatitis is not clear, and pancreatic and extrapancreatic reasons are discussed (Table 19.1).

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References

  1. Abrams CK, Hamosh M, Dutta SK, Hubbard VS, Hamosh P (1987) Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency. Gastroenterology 92: 125–129

    PubMed  CAS  Google Scholar 

  2. Abrams CK, Hamosh M, Hubbard VS, Dutta SK, Hamosh P (1984) Lingual lipase in cystic fibrosis. Quantitation of enzyme activity in the upper small intestine of patients with exocrine pancreatic insufficiency. J Clin Invest 73: 374–382

    Google Scholar 

  3. Abrams CK, Hamosh M, Lee TC, Ansher AF, Collen MJ, Lewis JH, Benjamin SB, Hamosh P (1988) Gastric lipase: localization in the human stomach. Gastroenterology 95: 1460–1464

    PubMed  CAS  Google Scholar 

  4. Adams DB, Ford MC, Anderson MC (1994) Outcome after lateral pancreaticojejunostomy for chronic pancreatitis. Ann Surg 219: 481–489

    PubMed  CAS  Google Scholar 

  5. Adler G, Miillenhoff A, Koop I, Bozkurt T, Göke B, Beglinger C, Arnold R (1988) Stimulation of pancreatic secretion in man by a protease inhibitor (camostate). Eur J Clin Invest 18: 98–104

    PubMed  CAS  Google Scholar 

  6. Adler G, Reinshagen M, Koop I, Göke B, Schafmayer A, Rovati LC, Arnold R (1989) Differential effects of atropine and a cholecystokinin receptor antagonist on pancreatic secretion. Gastroenterology 96: 1158–1164

    PubMed  CAS  Google Scholar 

  7. Ammann RW, Akovbiantz A, Largiadèr F, Schueler G (1984) Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology 86: 820–828

    PubMed  CAS  Google Scholar 

  8. Axon ATR, Classen M, Cotton PB, Cremer M, Freeny PC, Lees WR (1984) Pancreatography in chronic pancreatitis: international definitions. Gut 25: 1107–1112

    PubMed  CAS  Google Scholar 

  9. Balgha V, Pap A (1991) Bacterial overgrowth of small intestine demonstrated by H2 test in patients with chronic pancreatitis. Digestion 49: 6 (abstr)

    Google Scholar 

  10. Banks PA (1990) Pain in chronic pancreatitis: pathomechanism and clinical presentation. In: Beger HG, Büchler M, Ditschuneit H, Malfertheiner P (eds) Chronic Pancreatitis. Springer, Berlin-Heidelberg, pp 213–217

    Google Scholar 

  11. Banks PA (1991) Management of pancreatic pain. Pancreas 6, Suppl. 1: S52 - S59

    PubMed  Google Scholar 

  12. Baur X, Wießmann KJ, Wüthrich B (1984) Enzyme sind die allergenwirksamen Komponenten von inhaliertem Pankreatin. Dtsch Med Wochenschr 109: 257–260

    PubMed  CAS  Google Scholar 

  13. Beger HG, Büchler M, Bittner RR, Oettinger W, Roscher R (1989) Duodenum-preserving resection of the head of the pancreas in severe chronic pancreatitis. Early and late results. Ann Surg 209: 273–278

    PubMed  CAS  Google Scholar 

  14. Seger HG, Krautzberger W, Bittner R, Büchler M, Limmer J (1985) Duodenum-preserving resection of the head of the pancreas in patients with severe chronic pancreatitis. Surgery 97: 467–473

    Google Scholar 

  15. Bengtsson M, Löfström JB (1990) Nerve block in pancreatic pain. Acta Chir Scand 156: 285–291

    PubMed  CAS  Google Scholar 

  16. Bergner A, Bergner RK (1975) Pulmonary hypersensitivity associated with pancreatin powder exposure. Pediatrics 55: 814–817

    PubMed  CAS  Google Scholar 

  17. Beverley DW, Kelleher J, MacDonald A, Littlewood JM, Robinson T, Walters MP (1987) Comparison of four pancreatic extracts in cystic fibrosis. Arch Dis Child 62: 564–568

    PubMed  CAS  Google Scholar 

  18. Bittner R, Büchler M, Butters M, Leibl B, Nägele S, Roscher R, Beger HG (1992) Der Einfluß der duodenumerhaltenden Pankreaskopfresektion ( DPKR) auf die endokrine Pankreasfunktion bei Patienten mit chronischer Pankreatitis. Z Gastroenterol 30: 12–16

    PubMed  CAS  Google Scholar 

  19. Bloechle C, Izbicki JR, Knoefel WT, Kuechler T, Broelsch CE (1995) Quality of life in chronic pancreatitis–Results after duodenum-preserving resection of the head of the pancreas. Pancreas 11: 77–85

    PubMed  CAS  Google Scholar 

  20. Bockman DE, Buchler M, Malfertheiner P, Beger HG (1988) Analysis of nerves in chronic pancreatitis. Gastroenterology 94: 1459–1469

    PubMed  CAS  Google Scholar 

  21. Bornman PC, Marks IN, Girdwood AH, Clain JE, Narunsky L, Clain DJ, Wright JP (1980) Is pancreatic duct obstruction or stricture a major cause of pain in calcific pancreatitis? Br J Surg 67: 425–428

    PubMed  CAS  Google Scholar 

  22. Borowitz DS, Grand RJ, Durk PR, Consensus Committee (1995) Use of pancreatic enzyme supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. J Pediatr 127: 681–684

    PubMed  CAS  Google Scholar 

  23. Boyle BJ, Long WB, Balistreri WF, Widzer SJ, Huang N (1980) Effect of cimetidine and pancreatic enzymes on serum and fecal bile acids and fat absorption in cystic fibrosis. Gastroenterology 78: 950–953

    PubMed  CAS  Google Scholar 

  24. Bradley III EL (1982) Pancreatic duct pressure in chronic pancreatitis. Am J Surg 14–4: 313–316

    PubMed  Google Scholar 

  25. Bradley III EL (1987) Long-term results of pancreatojejunostomy in patients with chronic pancreatitis. Am J Surg 153: 207–213

    PubMed  Google Scholar 

  26. Büchler M, Weihe E, Friess H, Malfertheiner P, Bockman E, Müller S, Nohr D, Beger HG (1992) Changes in peptidergic innervation in chronic pancreatitis. Pancreas 7: 183–192

    PubMed  Google Scholar 

  27. Büchler MW, Friess H, Müller MW, Wheatley AM, Beger HG (1995) Randomized trial of duodenum-preserving pancreatic head resection versus pylorus-preserving Whipple in chronic pancreatitis. Am J Surg 169: 65–70

    PubMed  Google Scholar 

  28. Büchler MW, Uhl W, Malfertheiner P (1996) Pankreaserkrankungen. Akute Pankreatitis, chronische Pankreatitis, Tumore des Pankreas. Karger, Basel

    Google Scholar 

  29. Cameron JL, Mehigan DG, Broe PJ, Zuidema GD (1981) Distal pancreatectomy and islet auto-transplantation for chronic pancreatitis. Ann Surg 193: 312–317

    PubMed  CAS  Google Scholar 

  30. Capitaine Y, Roche B, Wiesner L, Hahnloser P (1988) Pancréatite chronique: histoire naturelle et évolution en relation avec l’alcoolisme. Schweiz Med Wochenschr 118: 817–820

    PubMed  CAS  Google Scholar 

  31. Couet C, Genton P, Pointel JP, Louis J, Gross P, Saudax E, Debry G, Drouin P (1985) The prevalence of retinopathy is similar in diabetes mellitus secondary to chronic pancreatitis with or without pancreatectomy and in idiopathic diabetes mellitus. Diabetes Care 8: 323–328

    PubMed  CAS  Google Scholar 

  32. Cox KL, Isenberg JN, Osher AB, Dooley RR (1979) The effect of cimetidine on maldigestion in cystic fibrosis. J Pediatr 94: 488–492

    PubMed  CAS  Google Scholar 

  33. Creutzfeldt W, Kern E, Kümmerle F, Schumacher J (1961) Die radikale Entfernung der Bauchspeicheldrüse beim Menschen–Indikationen, Ergebnisse, Folgeerscheinungen. In: Heilmeyer L, Schoen R, de Rudder B (eds) Ergebnisse der Inneren Medizin, Vol. 16. Springer, Berlin-Göttingen-Heidelberg, pp 79–124

    Google Scholar 

  34. Creutzfeldt W, Lankisch PG (1980) Totale Duodenopankreatektomie bei chronischer Pankreatitis. Z Gastroenterol 18: 641–643

    Google Scholar 

  35. Crist DW, Sitzmann pi, Cameron JL (1987) Improved hospital morbidity, mortality, and survival after the Whipple procedure. Ann Surg 206: 358–365

    PubMed  CAS  Google Scholar 

  36. Delhaye M, Hennart D, Bredas P, Engelman E, Cremer M (1994) Steroid and alcohol coeliac plexus block in chronic pancreatitis. Eur J Gastroenterol Hepatol 6: 553–558

    Google Scholar 

  37. Delhaye M, Vandermeeren A, Gabbrielli A, Cremer M (1990) Lithotripsie and endoscopy for pancreatic calculi: the first 104 patients. Gastroenterology 98: A216 (abstr)

    Google Scholar 

  38. Dellwyler W (1964) Le diabète des pancréatopathies. Sem Hop Paris 40: 1676–1682

    Google Scholar 

  39. Derfus GA, Geenen JE, Hogan WJ (1989) Alterations in pancreatic duct morphology associated with endoscopic stent placement. Pancreas 4: 613 (abstr)

    Google Scholar 

  40. Devière J, Devaere S, Baize M, Cremer M (1990) Endoscopic biliary drainage in chronic pancreatitis. Gastrointest Endosc 36: 96–100

    PubMed  Google Scholar 

  41. DiMagno EP (1979) Medical treatment of pancreatic insufficiency. Mayo Clin Proc 54: 435–442

    PubMed  CAS  Google Scholar 

  42. DiMagno EP (1982) Controversies in the treatment of exocrine pancreatic insufficiency. Dig Dis Sci 27: 481–484

    PubMed  CAS  Google Scholar 

  43. DiMagno EP, Bell JS, Perez MM, Regan PT, Go VLW, Moertel CG (1981) Malabsorption can be abolished in pancreatic insufficiency. Gastroenterology 80: 1136 (abstr)

    Google Scholar 

  44. DiMagno EP, Go VLW, Summerskill WHJ (1973) Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 288: 813–815

    PubMed  CAS  Google Scholar 

  45. DiMagno EP, Malagelada J-R, Go VLW (1979) The relationships between pancreatic ductal obstruction and pancreatic secretion in man. Mayo Clin Proc 54: 157–162

    PubMed  CAS  Google Scholar 

  46. DiMagno EP, Malagelada JR, Go VLW (1975) Relationship between alcoholism and pancreatic insufficiency. Ann N Y Acad Sci 252: 200–207

    PubMed  CAS  Google Scholar 

  47. DiMagno EP, Malagelada JR, Go VLW, Moertel CG (1977) Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules. N Engl J Med 296: 1318–1322

    PubMed  CAS  Google Scholar 

  48. Dolan TF Jr, Meyers A (1974) Bronchial asthma and allergic rhinitis associated with inhalation of pancreatic extracts. Am Rev Respir Dis 110: 812–813

    PubMed  Google Scholar 

  49. Drube HC, Büttner H (1964) Über die Wirkung oraler Kalziumgaben auf die Stuhlfettausscheidung bei Gesunden and Kranken mit Steatorrhoe. Med Klin 59: 1234–1236

    PubMed  CAS  Google Scholar 

  50. Drummond S, Saunders JHB, Leach R, Wormsley KG (1977) Enzymic activities of commercial preparations of pancreatic enzymes. Scot Med J 22: 221–224

    PubMed  CAS  Google Scholar 

  51. Dunaif G, Schneeman BO (1981) The effect of dietary fiber on human pancreatic enzyme activity in vitro. Am J Clin Nutr 34: 1034–1035

    PubMed  CAS  Google Scholar 

  52. Durie PR, Bell L, Linton W, Corey ML, Forstner GG (1980) Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. Gut 21: 778–786

    PubMed  CAS  Google Scholar 

  53. Dutta SK, Anand K, Gadacz TR (1986) Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis. Gastroenterology 91: 1243–1249

    PubMed  CAS  Google Scholar 

  54. Dutta SK, Bustin MP, Russell RM, Costa BS (1982) Deficiency of fat-soluble vitamins in treated patients with pancreatic insufficiency. Ann Intern Med 97: 549–552

    PubMed  CAS  Google Scholar 

  55. Dutta SK, Russell RM, Iber FL (1979) Impaired acid neutralization in the duodenum in pancreatic insufficiency. Dig Dis Sci 24: 775–780

    PubMed  CAS  Google Scholar 

  56. Dutta SK, Russell RM, Iber FL (1979) Influence of exocrine pancreatic insufficiency on the intra-luminal pH of the proximal small intestine. Dig Dis Sci 24: 529–534

    PubMed  CAS  Google Scholar 

  57. Ebbehoj N, Body L, Billow J, Gronvall Rasmussen S, Madsen P, Matzen P, Owre A (1990) Pancreatic tissue fluid pressure in chronic pancreatitis. Relation to pain, morphology, and function. Scand J Gastroenterol 25: 1046–1051

    Google Scholar 

  58. Ebbehoj N, Body L, Madsen P, Matzen P (1990) Pancreatic tissue fluid pressure during drainage operations for chronic pancreatitis. Scand J Gastroenterol 25: 1041–1045

    PubMed  CAS  Google Scholar 

  59. Ebbehoj N, Borly L, Madsen P, Svendsen LB (1986) Pancreatic tissue pressure and pain in chronic pancreatitis. Pancreas 1: 556–558

    PubMed  CAS  Google Scholar 

  60. Ebbehoj N, Svendsen LB, Madsen P (1984) Pancreatic tissue pressure: techniques and pathophysiological aspects. Scand J Gastroenterol 19: 1066–1068

    PubMed  CAS  Google Scholar 

  61. Freise J, Horstkotte H (1986) Exokrine Pankreasinsuffizienz. Vergleich einer Substitutionstherapie mit nichtsäureresistenten and einer säureresistenten Enzympräparation. Fortschr Med 104: 625–628

    PubMed  CAS  Google Scholar 

  62. Frey CF, Amikura K (1994) Local resection of the head of the pancreas combined with longitudinal pancreaticojejunostomy in the management of patients with chronic pancreatitis. Ann Surg 220: 492–507

    PubMed  CAS  Google Scholar 

  63. Frey CF, Braasch J (1984) Surgical management of chronic pancreatitis: the need to improve our observations and assessment of results. Am J Surg 147: 189–190

    Google Scholar 

  64. Frey CF, Child III CG, Fry W (1976) Pancreatectomy for chronic pancreatitis. Ann Surg 184: 403–414

    PubMed  CAS  Google Scholar 

  65. Frick S, Ebert M, Rückert K (1987) Chirurgie der chronischen Pankreatitis. II. Spätergebnisse nach nicht resezierenden Operationen. Dtsch Med Wochenschr 112: 832–837

    PubMed  CAS  Google Scholar 

  66. Frick S, Jung K, Rückert K (1987) Chirurgie der chronischen Pankreatitis. I. Spätergebnisse nach Resektionsbehandlung. Dtsch Med Wochenschr 112: 629–635

    PubMed  CAS  Google Scholar 

  67. Fuji T, Amano H, Ohmura R, Akiyama T, Aibe T, Takemoto T (1989) Endoscopic pancreatic sphincterotomy–technique and evaluation. Endoscopy 21: 27–30

    PubMed  CAS  Google Scholar 

  68. Gall FP, Gebhardt C, Zirngibl H (1982) Chronic pancreatitis–results in 116 consecutive, partial duodenopancreatectomies combined with pancreatic duct occlusion. Hepatogastroenterology 29: 115–119

    PubMed  CAS  Google Scholar 

  69. Girdwood AH, Marks IN, Bornman PC, Kottler RE, Cohen M (1981) Does progressive pancreatic insufficiency limit pain in calcific pancreatitis with duct stricture or continued alcohol insult? J Clin Gastroenterol 3: 241–245

    PubMed  CAS  Google Scholar 

  70. Gooszen HG, Schmidt JM, Van Heurn LWE, Jansen JBMJ, Lamers CBHW, Terpstra JL (1988) Surgical treatment for pain relief in chronic pancreatitis. Scand J Gastroenterol 23, Suppl. 154: 98–102

    Google Scholar 

  71. Gow R, Bradbear R, Francis P, Shepherd R (1981) Comparative study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: effectiveness of an enteric-coated preparation with and without antacids and cimetidine. Lancet 2: 1071–1074

    PubMed  CAS  Google Scholar 

  72. Grace PA, Pitt HA, Longmire WP (1990) Pylorus preserving pancreatoduodenectomy: an overview. Br J Surg 77: 968–974

    PubMed  CAS  Google Scholar 

  73. Grace PA, Pitt HA, Tompkins RK, DenBesten L, Longmire WP Jr (1986) Decreased morbidity and mortality after pancreatoduodenectomy. Am J Surg 151: 141–149

    PubMed  CAS  Google Scholar 

  74. Graham DY (1977) Enzyme replacement therapy of exocrine pancreatic insufficiency in man. Relation between in vitro enzyme activities and in vivo potency in commercial pancreatic extracts. N Engl J Med 296: 1314–1317

    PubMed  CAS  Google Scholar 

  75. Graham DY (1979) An enteric-coated pancreatic enzyme preparation that works. Dig Dis Sci 24: 906–909

    PubMed  CAS  Google Scholar 

  76. Graham DY (1982) Pancreatic enzyme replacement. The effect of antacids or cimetidine. Dig Dis Sci 27: 485–490

    PubMed  CAS  Google Scholar 

  77. Graham DY, Sackman JW (1982) Mechanism of increase in steatorrhea with calcium and magnesium in exocrine pancreatic insufficiency: an animal model. Gastroenterology 83: 638–644

    PubMed  CAS  Google Scholar 

  78. Greenlee HB, Prinz RA, Aranha GV (1990) Long-term results of side-to-side pancreaticojejunostomy. World J Surg 14: 70–76

    PubMed  CAS  Google Scholar 

  79. Grodsinsky C, Malcom S, Goldman J, Dienst S, Oh HK, Westrick P (1981) Islet cell autotransplantation after pancreatectomy for chronic pancreatitis. Its limitations. Arch Surg 116: 511–516

    PubMed  CAS  Google Scholar 

  80. Gullo L, Barbara L, Labò G (1988) Effect of cessation of alcohol use on the course of pancreatic dysfunction in alcoholic pancreatitis. Gastroenterology 95: 1063–1068

    PubMed  CAS  Google Scholar 

  81. Gullo L, Corinaldesi R, Casadio R, Vezzadini P, Tomassetti P, Ventrucci M, Priori P, Labò G (1983) Gastric acid secretion in chronic pancreatitis. Hepatogastroenterology 30: 60–62

    Google Scholar 

  82. Gullo L, Parenti M, Monti L, Pezzilli R, Barbara L (1990) Diabetic retinopathy in chronic pancreatitis. Gastroenterology 98: 1577–1581

    PubMed  CAS  Google Scholar 

  83. Halgreen H, Thorsgaard Pedersen N, Worning H (1986) Symptomatic effect of pancreatic enzyme therapy in patients with chronic pancreatitis. Scand J Gastroenterol 21: 104–108

    PubMed  CAS  Google Scholar 

  84. Hansen WE (1986) Effect of dietary fiber on proteolytic pancreatic enzymes in vitro. Int J Pancreatol 1: 341–351

    PubMed  CAS  Google Scholar 

  85. Hansen WE (1987) Effect of dietary fiber on pancreatic lipase activity in vitro. Pancreas 2: 195–198

    PubMed  CAS  Google Scholar 

  86. Hansen WE, Schulz G (1982) The effect of dietary fiber on pancreatic amylase activity in vitro. Hepatogastroenterology 29: 157–160

    PubMed  CAS  Google Scholar 

  87. Hayakawa T, Kondo T, Shibata T, Sugimuto Y, Kitagawa M (1989) Chronic alcoholism and evolution of pain and prognosis in chronic pancreatitis. Dig Dis Sci 34: 33–38

    PubMed  CAS  Google Scholar 

  88. Heizer WD, Cleaveland CR, Iber FL (1965) Gastric inactivation of pancreatic supplements. Bull Johns Hopkins Hosp 116: 261–270

    PubMed  CAS  Google Scholar 

  89. Hendeles L, Dorf A, Stecenko A, Weinberger M (1990) Treatment failure after substitution of generic pancrelipase capsules. Correlation with in vitro lipase activity. JAMA 263: 2459–2461

    PubMed  CAS  Google Scholar 

  90. Hill D (1975) Pancreatic extract lung sensitivity. Med J Aust 2: 553–555

    PubMed  CAS  Google Scholar 

  91. Hinshaw DB, Jolley WB, Hinshaw DB, Kaiser JE, Hinshaw K (1981) Islet autotransplantation after pancreatectomy for chronic pancreatitis with a new method of islet preparation. Am J Surg 142: 118–122

    PubMed  CAS  Google Scholar 

  92. Holmberg JT, Isaksson G, Ihse I (1985) Long term results of pancreticojejunostomy in chronic pancreatitis. Surg Gynecol Obstet 160: 339–346

    PubMed  CAS  Google Scholar 

  93. Huibregtse K, Schneider B, Vrij AA, Tytgat GNJ (1988) Endoscopic pancreatic drainage in chronic pancreatitis. Gastrointest Endosc 34: 9–15

    PubMed  CAS  Google Scholar 

  94. Hunter JG, White TW (1991) Gastrostomy and jejunostomy using a transgastric tube for early enteral nutrition after pylorus-preserving pancreaticoduodenectomy. Surg Gynecol Obstet 173: 316–318

    PubMed  CAS  Google Scholar 

  95. Ihse I, Lilja P (1979) Pancreatic enzymic activities of commercial pancreatic enzyme preparations incubated in human small intestinal juice. Digestion 19: 48–51

    PubMed  CAS  Google Scholar 

  96. Ihse I, Lilja P, Lundquist I (1977) Feedback regulation of pancreatic enzyme secretion by intestinal trypsin in man. Digestion 15: 303–308

    PubMed  CAS  Google Scholar 

  97. Isaksson G, Ihse I (1983) Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis. Dig Dis Sci 28: 97–102

    PubMed  CAS  Google Scholar 

  98. Isaksson G, Lilja P, Lundquist I, Ihse I (1983) Influence of dietary fiber on exocrine pancreatic function in the rat. Digestion 27: 57–62

    PubMed  CAS  Google Scholar 

  99. Isaksson G, Lundquist I, Ihse I (1982) Effect of dietary fiber on pancreatic enzyme activity in vitro. The importance of viscosity, pH, ionic strength, adsorption, and time of incubation. Gastroenterology 82: 918–924

    PubMed  CAS  Google Scholar 

  100. Jensen AR, Matzen P, Malchow-Moller A, Christoffersen I, The Copenhagen Pancreatitis Study Group (1984) Pattern of pain, duct morphology, and pancreatic function in chronic pancreatitis. A comparative study. Scand J Gastroenterol 19: 334–338

    PubMed  CAS  Google Scholar 

  101. Jordan PH, Grossman MI (1959) Effect of dosage schedule on the efficacy of substitution therapy in pancreatic insufficiency. Gastroenterology 36: 447–451

    PubMed  Google Scholar 

  102. Kalser MH, Leite CA, Warren WD (1968) Fat assimilation after massive distal pancreatectomy. N Engl J Med 279: 570–576

    PubMed  CAS  Google Scholar 

  103. Keith RG, Keshavjee SH, Kerenyi NR (1985) Neuropathology of chronic pancreatitis in humans. Can J Surg 28: 207–211

    PubMed  CAS  Google Scholar 

  104. Kozarek RA (1990) Pancreatic stents can induce ductal changes consistent with chronic pancreatitis. Gastrointest Endosc 36: 93–95

    PubMed  CAS  Google Scholar 

  105. Kozarek RA, Patterson DJ, Ball TJ, Traverso LW (1989) Endoscopic placement of pancreatic stents and drains in the management of pancreatitis. Ann Surg 209: 261–266

    PubMed  CAS  Google Scholar 

  106. Kölbel C, Layer P, Hotz J, Goebell H (1986) Der Einfluß eines säuregeschützten, mikroverkapselten Pankreatinpräparats auf die pankreatogene Steatorrhö. Med Klin 81: 85–86

    Google Scholar 

  107. Kremer H, Dobrinski W, Schreiber MA, Zöllner N (1984) Sonographie des Abdomens als Screeningmethode. Ultraschall 5: 272–276

    CAS  Google Scholar 

  108. Kühnelt P, Mundlos S, Adler G (1991) Einfluß der Pelletgröße eines Pankreasenzympräparates auf die duodenale lipolytische Aktivität. Z Gastroenterol 29: 417–421

    PubMed  Google Scholar 

  109. Lankisch PG (1984) Secretin test or secretin-CCK test–gold standard in pancreatic function testing? In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis–Concepts and classification. Excerpta Medica, ICS 642, Amsterdam-New York, pp 247–259

    Google Scholar 

  110. Lankisch PG (1991) Differential treatment of exocrine pancreatic insufficiency in chronic pancreatitis. In: Lankisch PG (ed) Pancreatic Enzymes in Health and Disease. Springer, Berlin-Heidelberg, pp 191–208

    Google Scholar 

  111. Lankisch PG (1993) Enzyme treatment of exocrine pancreatic insufficiency in chronic pancreatitis. Digestion 54 (Suppl 2): 21–29

    PubMed  Google Scholar 

  112. Lankisch PG (1993) Function tests in the diagnosis of chronic pancreatitis. Critical evaluation. Int J Pancreatol 14: 9–20

    PubMed  CAS  Google Scholar 

  113. Lankisch PG, Fuchs K, Peiper H-J, Creutzfeldt W (1981) Pancreatic function after drainage or resection for chronic pancreatitis. In: Mitchell CJ, Kelleher J (eds) Pancreatic disease in clinical practice. Pitman Books, London, pp 362–369

    Google Scholar 

  114. Lankisch PG, Fuchs K, Schmidt H, Peiper H-J, Creutzfeldt W (1975) Ergebnisse der operativen Behandlung der chronischen Pankreatitis mit besonderer Berücksichtigung der exokrinen and endokrinen Funktion. Dtsch Med Wochenschr 100: 1048–1060

    PubMed  CAS  Google Scholar 

  115. Lankisch PG, Lembcke B, Göke B, Creutzfeldt W (1986) Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage? Z Gastroenterol 24: 753–757

    PubMed  CAS  Google Scholar 

  116. Lankisch PG, Lembcke B, Kirchhoff S, Creutzfeldt W (1987) Therapy of pancreatogenic steatorrhea: a comparison between two acid-protected enzyme preparations. Dig Dis Sci 32: 1174 (abstr)

    Google Scholar 

  117. Lankisch PG, Lembcke B, Kirchhoff S, Hilgers R, Creutzfeldt W (1988) Therapie der pankreatogenen Steatorrhoe. Dtsch Med Wochenschr 113: 15–17

    PubMed  CAS  Google Scholar 

  118. Lankisch PG, Lembcke B, Wemken G, Creutzfeldt W (1986) Functional reserve capacity of the exocrine pancreas. Digestion 35: 175–181

    PubMed  CAS  Google Scholar 

  119. Lankisch PG, Löhr-Happe A, Otto J, Creutzfeldt W (1993) Natural course in chronic pancreatitis. Pain, exocrine and endocrine pancreatic insufficiency and prognosis of the disease. Digestion 54: 148–155

    PubMed  CAS  Google Scholar 

  120. Lankisch PG, Siewert R (1982) Postoperative Syndrome nach operativen Eingriffen am Pankreas. Internist 23: 494–502

    PubMed  CAS  Google Scholar 

  121. Larvin M, McMahon MJ, Thomas WEG, Puntis MCA (1991) Creon (enteric coated pancreatin microspheres) for the treatment of pain in chronic pancreatitis. A double blind randomised placebo controlled crossover study. Gastroenterology 100: A283 (abstr)

    Google Scholar 

  122. Layer P, Go VLW, DiMagno EP (1986) Fate of pancreatic enzymes during small intestinal aboral transit in humans. Am J Physiol 251: G475 - G480

    PubMed  CAS  Google Scholar 

  123. Layer P, Gröger G, Dicke D, v.d.Ohe M, Goebell H (1992) Enzyme pellet size and luminal nutrient digestion in pancreatic insufficiency. Digestion 52: 100–101 (abstr)

    Google Scholar 

  124. Layer P, Hohmann G (1994) Pancreatic enzymes in chronic pancreatitis. Int J Pancreatol 15: 1–11

    PubMed  CAS  Google Scholar 

  125. Layer P, Jansen JBMJ, Cherian L, Lamers CBHW, Goebell H (1990) Feedback regulation of human pancreatic secretion. Effects of protease inhibition on duodenal delivery and small intestinal transit of pancreatic enzymes. Gastroenterology 98: 1311–1319

    PubMed  CAS  Google Scholar 

  126. Leger L, Lenriot JP, Lemaigre G (1974) Five to twenty year follow-up after surgery for chronic pancreatitis in 148 patients. Ann Surg 180: 185–191

    PubMed  CAS  Google Scholar 

  127. Lembcke B, Kraus B, Lankisch PG (1985) Small intestinal function in chronic relapsing pancreatitis. Hepatogastroenterology 32: 149–151

    PubMed  CAS  Google Scholar 

  128. Lembcke B, Pohl M, Krackhardt B, Posselt HG (1995) A unique pattern of ileocaecal gut wall morphology related to pancreatic enzyme replacement therapy: an ultrasonography study in 200 cystic fibrosis patients. Gastroenterology 108: A369 (abstr)

    Google Scholar 

  129. Leung JWC, Bowen-Wright M, Aveling W, Shorvon PJ, Cotton PB (1983) Coeliac plexus block for pain in pancreatic cancer and chronic pancreatitis. Br J Surg 70: 730–732

    PubMed  CAS  Google Scholar 

  130. Lev-Ran A (1978) Clinical observation on brittle diabetes. Arch Intern Med 138: 372–376

    PubMed  CAS  Google Scholar 

  131. Levitt NS, Adams G, Salmon J, Marks INS, Musson G, Swanepoel C, Levy M, Byrne MJ (1995) The prevalence and severity of microvascular complications in pancreatic diabetes and IDDM. Diabetes Care 18: 971–974

    PubMed  CAS  Google Scholar 

  132. Liener IE, Goodale RL, Deshmukh A, Satterberg TL, Ward G, DiPietro CM, Sankey PE, Borner JW (1988) Effect of a trypsin inhibitor from soybeans ( Bowman-Birk) on the secretory activity of the human pancreas. Gastroenterology 94: 419–427

    PubMed  CAS  Google Scholar 

  133. Linde J, Nilsson LH, Bârâny FR (1977) Diabetes and hypoglycemia in chronic pancreatitis. Scand J Gastroenterol 12: 369–373

    PubMed  CAS  Google Scholar 

  134. Lipkin GW, Vickers DW (1987) Allergy in cystic fibrosis nurses to pancreatic extract. Lancet 1: 392

    PubMed  CAS  Google Scholar 

  135. Lloyd-Still JD (1995) Editorial: Cystic fibrosis and colonic strictures. A new “iatrogenic” disease. J Clin Gastroenterol 21: 2–5

    PubMed  CAS  Google Scholar 

  136. Lopez JJ, Wright JA, Hammer RA, Ertan A (1992) Chronic pancreatitis is associated with a high prevalence of giardiasis. Can J Gastroenterol 6: 73–76

    Google Scholar 

  137. Löhr A (1990) Der natürliche Verlauf der chronischen Pankreatitis. Die Entwicklung der Leitsymptome Schmerzen, exokrine and endokrine Pankreasinsuffizienz and die Prognose der Erkrankung. Med Diss Göttingen

    Google Scholar 

  138. Mac Sweeney EJ, Oades PJ, Buchdahl R, Rosenthal M, Bush A (1995) Relation of thickening of colon wall to pancreatic-enzyme treatment in cystic fibrosis. Lancet 345: 752–756

    PubMed  CAS  Google Scholar 

  139. Madsen P, Hansen E (1985) Coeliac plexus block versus pancreaticogastrostomy for pain in chronic pancreatitis. A controlled randomized trial. Scand J Gastroenterol 20: 1217–1220

    PubMed  CAS  Google Scholar 

  140. Madsen P, Winkler K (1982) The intraductal pancreatic pressure in chronic obstructive pancreatitis. Scand J Gastroenterol 17: 553–554

    PubMed  CAS  Google Scholar 

  141. Malesci A, Gaia E, Fioretta A, Bocchia P, Ciravegna G, Cantor P, Vantini I (1995) No effect of long-term treatment with pancreatic extract on recurrent abdominal pain in patients with chronic pancreatitis. Scand J Gastroenterol 30: 392–398

    PubMed  CAS  Google Scholar 

  142. Malfertheiner P, Büchler M, Stanescu A, Ditschuneit H (1987) Pancreatic morphology and function in relationship to pain in chronic pancreatitis. Int J Pancreatol 2: 59–66

    PubMed  CAS  Google Scholar 

  143. Malfertheiner P, Mayer D, Büchler M, Dominguez-Munoz JE, Schiefer B, Ditschuneit H (1995) Treatment of pain in chronic pancreatitis by inhibition of pancreatic secretion with octreotide. Gut 36: 450–454

    PubMed  CAS  Google Scholar 

  144. Mangold G, Neher M, Oswald B, Wagner G (1977) Ergebnisse der Resektionsbehandlung der chronischen Pankreatitis. Dtsch Med Wochenschr 102: 229–234

    PubMed  CAS  Google Scholar 

  145. Mannell A, Adson MA, McIlrath DC, Ilstrup DM (1988) Surgical management of chronic pancreatitis: long-term results in 141 patients. Br J Surg 75: 467–472

    PubMed  CAS  Google Scholar 

  146. McHugh K, Thomson A, Tam P (1994) Case report: Colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis. Br J Radiol 67: 900–901

    CAS  Google Scholar 

  147. Mehigan DG, Bell WR, Zuidema GD, Eggleston JC, Cameron JL (1980) Disseminated intravascular coagulation and portal hypertension following pancreatic islet autotransplantation. Ann Surg 191: 287–293

    PubMed  CAS  Google Scholar 

  148. Meyer JH (1991) Delivery of pancreatin in microsphere preparations: transit, timing, physiological needs. In: Lankisch PG (ed) Pancreatic Enzymes in Health and Disease. Springer, Berlin-Heidelberg, pp 71–88

    Google Scholar 

  149. Meyer JH, Elashoff J, Porter-Fink V, Dressman J, Amidon GL (1988) Human postprandial gastric emptying of 1–3-millimeter spheres. Gastroenterology 94: 1315–1325

    PubMed  CAS  Google Scholar 

  150. Mizumoto A, Koike D, Sarr MG, DiMagno EP (1994) How important is mixing of lipase and nutrients in decreasing pancreatic steatorrhea? Gastroenterology 106: A308 (abstr)

    Google Scholar 

  151. Morrow CE, Cohen JI, Sutherland DER, Najarian JS (1984) Chronic pancreatitis: long-term surgical results of pancreatic duct drainage, pancreatic resection, and near-total pancreatectomy and islet autotransplantation. Surgery 96: 608–616

    PubMed  CAS  Google Scholar 

  152. Mössner J, Secknus R, Meyer J, Niederau C, Adler G (1992) Treatment of pain with pancreatic extracts in chronic pancreatitis: results of a prospective placebo-controlled multicenter trial. Digestion 53: 54–66

    PubMed  Google Scholar 

  153. Mössner J, Wresky HP, Back T (1990) Does feedback regulation exist in chronic pancreatitis? In: Beger HG, Büchler M, Ditschuneit H, Malfertheiner P (eds) Chronic Pancreatitis. Springer, Berlin-Heidelberg, pp 198–209

    Google Scholar 

  154. Mundlos S, Kühnelt P, Adler G (1990) Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test. Gut 31: 1324–1328

    PubMed  CAS  Google Scholar 

  155. Najarian JS, Sutherland DER, Baumgartner D, Burke B, Rynasiewicz JJ, Matas AJ, Goetz FC (1980) Total or near total pancreatectomy and islet autotransplantation for treatment of chronic pancreatitis. Ann Surg 192: 526–542

    PubMed  CAS  Google Scholar 

  156. Nealon WH, Thompson JC (1993) Progressive loss of pancreatic function in chronic pancreatitis is delayed by main pancreatic duct decompression. A longitudinal prospective analysis of the modified Puestow procedure. Ann Surg 217: 458–468

    PubMed  CAS  Google Scholar 

  157. Nealon WH, Townsend CM Jr, Thompson JC (1988) Operative drainage of the pancreatic duct delays functional impairment in patients with chronic pancreatitis. A prospective analysis. Ann Surg 208: 321–329

    PubMed  CAS  Google Scholar 

  158. Neuhaus H, Hoffmann W, Classen M (1992) Laser lithotripsy of pancreatic and biliary stones via 3.4 mm and 3.7 mm miniscopes: first clinical results. Endoscopy 24: 208–214

    PubMed  CAS  Google Scholar 

  159. Niessen KH, Wolf A (1982) Studies on the cause of hyperuricosuria in cystic fibrosis patients. J Pediatr Gastroenterol Nutr 1: 349–354

    PubMed  CAS  Google Scholar 

  160. Nousia-Arvanitakis S, Stapleton FB, Linshaw MA, Kennedy J (1977) Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. Pediatrics 90: 302–305

    Google Scholar 

  161. Novis BH, Bornman PC, Girdwood AW, Marks IN (1985) Endoscopic manometry of the pancreatic duct and sphincter zone in patients with chronic pancreatitis. Dig Dis Sci 30: 225–228

    PubMed  CAS  Google Scholar 

  162. Ogden JM, O’Keefe SJD, Louw JA, Adams G, Marks IN (1993) Duodenal juice total protein and pancreatic enzyme synthesis, turnover, and secretion in patients after acute pancreatitis. Gut 34: 1261–1266

    PubMed  CAS  Google Scholar 

  163. Okazaki K, Yamamoto Y, Kagiyama S, Tamura S, Sakamoto Y, Morita M (1988) Pressure of papillary sphincter zone and pancreatic main duct in patients with alcoholic and idiopathic chronic pancreatitis. Int J Pancreatol 3: 457–468

    PubMed  CAS  Google Scholar 

  164. Owyang C, Louie DS, Tatum D (1986) Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin. J Clin Invest 77: 2042–2047

    PubMed  CAS  Google Scholar 

  165. Pap A, Nauss LA, DiMagno EP (1990) Is percutaneous celiac plexus block (PCPB) associated with pain relief in chronic pancreatitis? A comparison among analgesic, alcohol and steroid PCPB. Pancreas 5: 725 (abstr)

    Google Scholar 

  166. Peiper H-J, Köhler H (1989) Chirurgische Therapie der chronischen Pankreatitis. Schweiz Med Wochenschr 119: 712–716

    PubMed  CAS  Google Scholar 

  167. Peschke GJ (1991) Active components and galenic aspects of enzyme preparations. In: Lankisch PG (ed) Pancreatic Enzymes in Health and Disease. Springer, Berlin-Heidelberg, pp 55–64

    Google Scholar 

  168. Prinz RA, Greenlee HB (1981) Pancreatic duct drainage in 100 patients with chronic pancreatitis. Ann Surg 194: 313–320

    PubMed  CAS  Google Scholar 

  169. Proctor HJ, Mendes OC, Thomas CG Jr, Herbst CA (1979) Surgery for chronic pancreatitis. Drainage versus resection. Ann Surg 189: 664–671

    PubMed  CAS  Google Scholar 

  170. Raimondo M, DiMagno EP (1994) Lipolytic activity of bacterial lipase survives better than that of porcine lipase in human gastric and duodenal content. Gastroenterology 107: 231–235

    PubMed  CAS  Google Scholar 

  171. Rämö OJ, Puolakkainen PA, Seppälä K, Schröder TM (1989) Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand J Gastroenterol 24: 688–692

    PubMed  Google Scholar 

  172. Regan PT, DiMagno EP (1980) Exocrine pancreatic insufficiency in celiac sprue: a cause of treatment failure. Gastroenterology 78: 484–487

    PubMed  CAS  Google Scholar 

  173. Regan PT, Malagelada J-R, DiMagno EP, Glanzman SL, Go VLW (1977) Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. N Engl J Med 297: 854–858

    PubMed  CAS  Google Scholar 

  174. Regan PT, Malagelada J-R, DiMagno EP, Go VLW (1979) Reduced intraluminal bile acid concentrations and fat maldigestion in pancreatic insufficiency: correction by treatment. Gastroenterology 77: 285–289

    PubMed  CAS  Google Scholar 

  175. Ribet A, Balas D, Bommelaer G, Pradayrol L, Varignon M (1979) Activité enzymatique “in vitro” de différents extraits pancréatiques. Gastroenterol Clin Biol 3: 515–520

    PubMed  CAS  Google Scholar 

  176. Roberts IM (1989) Enzyme therapy for malabsorption in exocrine pancreatic insufficiency. Pancreas 4: 496–503

    PubMed  CAS  Google Scholar 

  177. Rolny P, Ärlebäck A, Järnerot G, Andersson T (1986) Endoscopic manometry of the sphincter of Oddi and pancreatic duct in chronic pancreatitis. Scand J Gastroenterol 21: 415–420

    PubMed  CAS  Google Scholar 

  178. Rolny P, Ferstenberg R, Hogan WJ, Geenen JE (1990) Pancreatic exocrine function in patients with ductal alterations associated with endoscopic stent placement. Gastroenterology 98: A232 (abstr)

    Google Scholar 

  179. Rosenberger J, Stock W, Altmann P, Pichlmaier H (1980) Spätergebnisse nach organerhaltenden and resezierenden Eingriffen wegen chronischer Pankreatitis. Leber Magen Darm 10: 22–27

    PubMed  CAS  Google Scholar 

  180. Rossi RL, Rothschild J, Braasch JW, Munson JL, ReMine SG (1987) Pancreatoduodenectomy in the management of chronic pancreatitis. Arch Surg 122: 416–420

    PubMed  CAS  Google Scholar 

  181. Sakula A (1977) Bronchial asthma due to allergy to pancreatic extract. Lancet 2: 193

    PubMed  CAS  Google Scholar 

  182. Sarles H, Pastor J, Pauli AM, Barthelemy M (1963) Determination of pancreatic function. A statistical analysis conducted in normal subjects and in patients with proven chronic pancreatitis (duodenal intubation, glucose tolerance test, determination of fat content in the stools, sweat test). Gastroenterologia 99: 279–300

    Google Scholar 

  183. Sarles H, Sahel J (1976) Die chronische Pankreatitis. In: Forell M (ed) Handbuch der Inneren Medizin, Vol. 3/6, Pankreas. 5th edn. Springer, Berlin-Heidelberg-New York, pp 737–844

    Google Scholar 

  184. Sato T, Miyashita E, Matsuno S, Yamauchi H (1986) The role of surgical treatment for chronic pancreatitis. Ann Surg 203: 266–271

    PubMed  CAS  Google Scholar 

  185. Sato T, Noto N, Matsuno S, Miyakawa K (1981) Follow-up results of surgical treatment for chronic pancreatitis. Present status in Japan. Am J Surg 142: 317–323

    PubMed  CAS  Google Scholar 

  186. Sauerbruch T, Holl J, Sackmann M, Paumgartner G (1989) Extracorporeal shock wave lithotripsy of pancreatic stones. Gut 30: 1406–1411

    PubMed  CAS  Google Scholar 

  187. Saunders JHB, Cargill JM, Wormsley KG (1978) Gastric secretion of acid in patients with pancreatic disease. Digestion 17: 365–369

    PubMed  CAS  Google Scholar 

  188. Schneider MU, Domschke S, Heptner G, Domschke W (1984) Einfluß von Pflanzenfasern auf die lipolytische and proteolytische exokrine Pankreasfunktion. Dtsch Med Wochenschr 109: 250–253

    PubMed  CAS  Google Scholar 

  189. Sherman S, Lehman GA, Hawes RH, Ponich T, Miller LS, Cohen LB, Kortan P, Haber GB (1991) Pancreatic ductal stones: frequency of successful endoscopic removal and improvement in symptoms. Gastrointest Endosc 37: 511–517

    PubMed  CAS  Google Scholar 

  190. Slaff J, Jacobson D, Tillman CR, Curington C, Toskes P (1984) Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology 87: 44–52

    PubMed  CAS  Google Scholar 

  191. Smyth RL, van Velzen D, Smyth AR, Lloyd DA, Heaf DP (1994) Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 343: 85–86

    PubMed  CAS  Google Scholar 

  192. Stapleton FB, Kennedy J, Nousia-Arvanitakis S, Linshaw MA (1976) Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis. N Engl J Med 295: 246–248

    PubMed  CAS  Google Scholar 

  193. Staritz M, Meyer zum Büschenfelde KH (1988) Elevated pressure in the dorsal part of pancreas divisum: the cause of chronic pancreatitis? Pancreas 3: 108–110

    PubMed  CAS  Google Scholar 

  194. Staub JL, Sarles H, Soule JC, Galmiche JP, Capron JP (1981) No effect of cimetidine on the therapeutic response to oral enzymes in severe pancreatic insufficiency. N Engl J Med 304: 1364–1365

    PubMed  CAS  Google Scholar 

  195. Stead RJ, Skypala I, Hodson ME (1988) Treatment of steatorrhea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine. Aliment Pharmacol Ther 2: 471–482

    PubMed  CAS  Google Scholar 

  196. Stead RJ, Skypala I, Hodson ME, Batten JC (1987) Enteric coated microspheres of pancreatin in the treatment of cystic fibrosis: comparison with a standard enteric coated preparation. Thorax 42: 533–537

    PubMed  CAS  Google Scholar 

  197. Stone WM, Sarr MG, Nagorney DM, Mellrath DC (1988) Chronic pancreatitis. Results of Whipple’s resection and total pancreatectomy. Arch Surg 123: 815–819

    PubMed  CAS  Google Scholar 

  198. Taylor CJ, Steiner GM (1995) Fibrosing colonopathy in a child on low-dose pancreatin. Lancet 346: 1106–1107

    PubMed  CAS  Google Scholar 

  199. Taylor RH, Bagley FH, Braasch JW, Warren KW (1981) Ductal drainage or resection for chronic pancreatitis. Am J Surg 141: 28–33

    PubMed  CAS  Google Scholar 

  200. Thiruvengadam R, DiMagno EP (1988) Inactivation of human lipase by proteases. Am J Physiol 255: G476 - G481

    PubMed  CAS  Google Scholar 

  201. Toledo-Pereyra LH (1983) Islet cell autotransplantation after subtotal pancreatectomy. Arch Surg 118: 851–858

    PubMed  CAS  Google Scholar 

  202. Traverso LW, Abou-Zamzam AM, Longmire WP Jr (1981) Human pancreatic cell autotransplantation following total pancreatectomy. Ann Surg 193: 191–195

    PubMed  CAS  Google Scholar 

  203. Twarog FJ, Weinstein SF, Khaw KT, Strieder DJ, Cotten HR (1977) Hypersensitivity to pancreatic extracts in parents of patients with cystic fibrosis. J Allergy Clin Immunol 59: 35–40

    PubMed  CAS  Google Scholar 

  204. Ventrucci M, Gullo L, Costa PL, Bolondi L, Caletti GC, Corcioni E, Nesticò V (1980) Relation between pancreatic lipase and steatorrhoea in pancreatic disease. Ital J Gastroenterol 12: 76–78

    Google Scholar 

  205. Walsh DB, Eckhauser FE, Cronenwett JL, Turcotte JG, Lindenauer SM (1982) Adenocarcinoma of the ampulla of Vater. Ann Surg 195: 152–157

    PubMed  CAS  Google Scholar 

  206. Warshaw AL, Torchiana DL (1985) Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy. Surg Gynecol Obstet 160: 1–4

    PubMed  CAS  Google Scholar 

  207. Way LW, Gadacz T, Goldman L (1974) Surgical treatment of chronic pancreatitis. Am J Surg 127: 202–209

    PubMed  CAS  Google Scholar 

  208. White TT (1981) Surgical treatment of chronic pancreatitis. Report of 227 cases. Jpn J Surg 11: 1–7

    PubMed  CAS  Google Scholar 

  209. Williamson RCN, Bliouras N, Cooper MJ, Davies ER (1993) Gastric emptying and enterogastric reflux after conservative and conventional pancreatoduodenectomy. Surgery 114: 82–86

    PubMed  CAS  Google Scholar 

  210. Wright JA, Lopez J, Daum RS, Ertan A (1988) Chronic pancreatitis is associated with a high prevalence of giardiasis. Gastroenterology 94: A503 (abstr)

    Google Scholar 

  211. Yeo CJ, Barry MK, Sauter PK, Sostre S, Lillemoe KD, Pitt HA, Cameron JL (1993) Erythromycin accelerates gastric emptying after pancreaticoduodenectomy. A prospective, randomized, placebo-controlled trial. Ann Surg 218: 229–238

    PubMed  CAS  Google Scholar 

  212. Zempsky WT, Rosenstein BJ, Carroll JA, Oski FA (1989) Effect of pancreatic enzyme supplements on iron absorption. Am J Dis Child 143: 969–972

    PubMed  CAS  Google Scholar 

  213. Zentler-Munro PL, Fine DR, Northfield TC (1981) Mechanism whereby cimetidine enhances pancreatic enzyme therapy. Gastroenterology 80: 1323

    Google Scholar 

  214. Zerega J, Lerner S, Meyer JH (1988) Duodenal instillation of pancreatin does not abolish steatorrhea in patients with pancreatic insufficiency. Dig Dis Sci 33: 1245–1249

    PubMed  CAS  Google Scholar 

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  1. Medizinische Klinik, Städtisches Krankenhaus, Bögelstraße 1, D-21339, Lüneburg, Germany

    Prof. Dr. P. G. Lankisch

  2. Gastroenterology Division, Brigham and Women’s Hospital, 75 Francis Street, 02115, Boston, MA, USA

    Peter A. Banks M.D. (Associate Professor of Medicine, Harvard Medical School, Director, Clinical Gastroenterology Service)

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Lankisch, P.G., Banks, P.A. (1998). Chronic Pancreatitis: Treatment. In: Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80320-8_19

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