Neurogenesis in the Adult Brain: Lessons Learned from the Studies of Progenitor Cells from the Embryonic and Adult Central Nervous Systems
The developing brain represents a spectrum of differentiation, encompassing at one end mature differentiated cells with no ability to divide and at the other end a rare, self-sustaining population of stem cells that have the ability to give rise to all the cells of the central nervous system (CNS). In between these two extremes are cells termed progenitor cells, which are functionally immature and retain a limited proliferative capacity (Fig. 1). Although the presence of stem and progenitor cells within the CNS is a subject of great interest and debate, they are elusive cells and have not been definitely identified by the expression of a set of pheno-typic markers, like the stem cells in the hemopoeitic system.
KeywordsProgenitor Cell Nerve Growth Factor Adult Brain Basic Fibroblast Growth Factor Subventricular Zone
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