Mast Cells and Neutrophils in Intestinal Ischemia/Reperfusion

  • P. Kubes
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 26)


The key features of reperfusion of ischemic intestine associated with hemorrhage and other shock states include microvascular and mucosal alterations such as endothelial cell swelling, capillary plugging, a prolonged reduction in intestinal blood flow and mucosal barrier dysfunction [1–3]. The intestinal lesion becomes a very important factor inasmuch as loss of a restrictive lumenal barrier is strongly associated with toxic factors entering the circulation and causing sepsis and possibly multiple organ failure in patients otherwise recovering from shock [2].


Mast Cell Sodium Cromoglycate Mast Cell Degranulation Neutrophil Recruitment Intravital Microscopy 
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© Springer-Verlag Berlin Heidelberg 1996

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  • P. Kubes

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