Growth Factors and the Intestine

  • P. Fürst
  • J. L. Rombeau
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 26)


One of the most exciting achievements of the medical research community has been the characterization of a diverse family of signal molecules, the growth factors (GF), which are involved in the control of cell growth and differentiation, and may play a crucial role in numerous diseased conditions. The origin of this research lies in the studies of S. Cohen, R. Levi-Montalchini, D. Metcalf and others who first used complex biological assays to characterize epidermal and nerve GF and the colony stimulating factors (CSF), respectively. Indeed, these works stimulated many groups to establish methods for elucidation of both their biological role and mechanism of molecular action through specific receptors. Particularly important to the development of the field has been the ability to employ characterized single peptide species. The availability of pure factors and modern molecular and cellular techniques has firmly established the central role of these signal molecules in many aspects of biology. The realization that the factors trigger through specific receptors, the generation of second messengers and hence intracellular enzyme cascades generated new insight into the mechanisms which may be operating in diseases and during critical illness. In addition, these studies have stimulated the introduction of novel methods for manipulating GF-induced signal cascades which could be important in many pathological conditions.


Hepatocyte Growth Factor Intestinal Epithelial Cell Massive Small Bowel Resection Mucosal Growth Intestinal Cell Proliferation 
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  • P. Fürst
  • J. L. Rombeau

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