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Human Cellular Immune Responses to Mycobacterium tuberculosis

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Book cover Tuberculosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 215))

Abstract

Human infection with Mycobacterium tuberculosis results in a broad spectrum of outcomes ranging from asymptomatic infection to widespread and rapidly fatal disease. It is generally believed that this spectrum of clinical manifestations reflects a complex interaction between M. tuberculosis and human immune defenses. The immune response to tuberculosis is a double-edged sword that can contribute both to clearance of infection and tissue damage. This chapter summarizes our current understanding of human cellular immune responses to M. tuberculosis.

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Authors and Affiliations

  1. University of Southern California School of Medicine, HMR 904, 2025 Zonal Avenue, Los Angeles, CA, 90033, USA

    P. F. Barnes

  2. UCLA School of Medicine, 52-121 CHS, 10833 LeConte Avenue, Los Angeles, CA, 90024-1750, USA

    R. L. Modlin

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  1. Department of Health and Human Services, Immunology and Molecular Pathogenesis Section, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, 30333, Atlanta, GA, USA

    Thomas M. Shinnick Ph.D. (Chief) (Chief)

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Barnes, P.F., Modlin, R.L. (1996). Human Cellular Immune Responses to Mycobacterium tuberculosis . In: Shinnick, T.M. (eds) Tuberculosis. Current Topics in Microbiology and Immunology, vol 215. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80166-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-80166-2_9

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