Tuberculosis pp 131-156 | Cite as

Virulence Determinants of Mycobacterium tuberculosis

  • F. D. Quinn
  • G. W. Newman
  • C. H. King
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 215)

Abstract

Microbial pathogenicity has been defined as “the biochemical mechanisms whereby microorganisms cause disease” (Smith 1968); however, the actual process is much more dramatic. The interaction between host and pathogen during disease is a dynamic confrontation where the microbe’s strategies for survival meet face to face with the formidable defenses of the immune system. The tactics employed by both participants provide fascinating topics for researchers of many disciplines. Advances, fueled largely by the application of molecular biology, have been made in the biochemistry, immunology, and cell biology of the host-parasite interaction. Among the many new insights is the recognition that bacterial pathogens have evolved sophisticated signal transduction systems controlling the coordinate expression of virulence determinants.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • F. D. Quinn
    • 1
  • G. W. Newman
    • 1
  • C. H. King
    • 1
  1. 1.Division of AIDS, STD, and TB Laboratory ResearchCenters for Disease Control and PreventionAtlantaUSA

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