Abstract
Cochlear perilymph (PL) — a major intralabyrinthine fluid — is considered to play an important role in the auditory function of the inner ear. However, despite numerous studies of the biochemistry and physiology of PL, its formation and composition — derived from cerebrospinal fluid (CSF) versus ultrafiltrate of blood plasma — have long been a controversial subject. This is also true for its metabolic function for the organ of Corti. To elucidate this problem, we systematically investigated a number of essential chemical components (glucose, pyruvate, lactate, sodium, potassium, protein, lactate dehydrogenase) in PL, CSF and blood plasma of anesthetized guinea pigs (Scheibe and Haupt 1985) with due consideration of significant sources of error connected with the sampling procedure, particularly the contamination of PL with CSF (Bergmann et al. 1979; Scheibe et al. 1984). In addition, we have recently analyzed the total magnesium concentration in these fluids. The complete analytical data are compiled in a brief review. The results of our and other relevant studies are discussed with regard to the current view on the formation and biochemical nature of PL and its interaction with CSF.
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References
Bergmann K, Haupt H, Scheibe F, Rogge I (1979) Der Verschluß des Aquaeductus cochleae fur Perilymphuntersuchungen am Meerschweinchen. Arch Otorhinolaryngol 224: 257–265
Giebel W (1974) Proteins and amino acids in inner ear fluids. Excerpta Medica ICS 337: 790–793
Hara A, Salt AN, Thalmann R (1989) Perilymph composition in scala tympani of the cochlea: influence of cerebrospinal fluid. Hear Res 42: 265–272
Inamura N, Salt AN (1992) Permeability changes of the blood-labyrinth barrier measured in vivo during experimental treatments. Hear Res 61: 12–18
Juhn SK, Rybak LP (1981) Labyrinthine barriers and cochlear homeostasis. Acta Otolaryngol 91: 529–534
Kommoss J, Giebel W (1978) Die Ausbreitung löslicher Substanzen nach Applikation in die Cisterna cerebellomedularis. Arch Otorhinolaryngol 221: 67–76
Ohyama K, Salt AN, Thalmann R (1988) Volume flow rate of perilymph in the guinea-pig cochlea. Hear Res 35: 119–130
Salt AN, Inamura N, Thalmann R, Vora AR (1991) Evaluation of procedures to reduce fluid flow in the fistulized guinea-pig cochlea. Acta Otolaryngol (Stockh) 111: 899–907
Scheibe F, Haupt H (1985) Biochemical differences between perilymph, cerebrospinal fluid and blood plasma in the guinea pig. Hear Res 17: 61–66
Scheibe F, Haupt H, Bergmann K (1984) On sources of error in the biochemical study of perilymph (guinea-pig). Arch Otorhinolaryngol 240: 43–48
Scheibe F, Haupt H, Hache U, Gerhardt H-J, Lauterbach H (1975) Zur Proteinkonzentration der Meerschweinchen-Perilymphe. Acta Otolaryngol 79: 51–57
Sterkers O, Ferrary E, Amiel C (1988) Production of inner ear fluids. Physiol Rev 68: 1083–1128
Thalmann I, Comegys TH, Liu SZ, Ito Z, Thalmann R (1992) Protein profiles of perilymph and endolymph of the guinea pig. Hear Res 63: 37–42
Thalmann R, Comegys T, Thalmann I (1982) Amino acid profiles in inner ear fluids and cerebrospinal fluid. Laryngoscope 92: 321–328
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© 1996 Springer-Verlag Berlin Heidelberg
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Scheibe, F., Haupt, H. (1996). Differences in biochemical composition between perilymph, cerebrospinal fluid and blood plasma in the guinea pig. In: Ernst, A., Marchbanks, R., Samii, M. (eds) Intracranial and Intralabyrinthine Fluids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80163-1_14
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DOI: https://doi.org/10.1007/978-3-642-80163-1_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80165-5
Online ISBN: 978-3-642-80163-1
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