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Apolipoprotein E and Alzheimer’s Disease: State of the Field After Two Years

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Apolipoprotein E and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Abstract

In October 1992, at the Alzheimer’s Disease Research Center Directors’ meeting at the Society for Neurosciences (Anaheim, California), we reported that the apolipoprotein E-ε4 allele frequency was increased in late-onset familial Alzheimer’s disease. There was no press release or news conference and, in fact, only one mention was made of these data by a reporter from the Journal NIH Research who attended the meeting. The first published paper appeared five months later in March 1993,26 months before this IPSEN Fondation conference (Strittmatter et al. 1993a). In April 1993, during a 10-minute platform presentation at the American Academy of Neurology meeting, the association of APOE4 with 176 autopsy-confirmed cases of sporadic late-onset Alzheimer disease was presented (Saunders et al. 1993). There was no press release or public announcement for these data, which remained in press until August 1993. Because the Academy meeting was held in New York City, it was attended by a local medical science reporter from the Wall Street Journal who was impressed with the spirited criticism during the five minute question period and the hallway discussion that followed.

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Authors and Affiliations

  1. Departments of Medicine (Neurology) and Neurobiology, Joseph and Kathleen Bryan Alzheimer’s Disease Research Center, Duke University Medical Center, P.O. Box 2900, Durham, NC, 27710, USA

    A. D. Roses

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  1. A. D. Roses
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  2. W. J. Strittmatter
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  3. A. M. Saunders
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  4. D. E. Schmechel
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  5. M. A. Pericak-Vance
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Editor information

Editors and Affiliations

  1. Joseph and Kathleen Bryan Alzheimer’s Disease Research Center Departments of Medicine (Neurology) and Neurobiology, Duke University Medical Center, P.O. Box 2900, Durham, NC, 27710, USA

    A. D. Roses M.D.

  2. Gladstone Institute of Cardiovascular Disease Department of Pathology, Cardiovascular Research Institute, University of California, San Francisco, CA, 94141-9100, USA

    K. Weisgraber M.D.

  3. Fondation IPSEN, 24, rue Erlanger, 75781, Paris, France

    Y. Christen Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Roses, A.D., Strittmatter, W.J., Saunders, A.M., Schmechel, D.E., Pericak-Vance, M.A. (1996). Apolipoprotein E and Alzheimer’s Disease: State of the Field After Two Years. In: Roses, A.D., Weisgraber, K., Christen, Y. (eds) Apolipoprotein E and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80109-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-80109-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80111-2

  • Online ISBN: 978-3-642-80109-9

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