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Cell-Surface GPI Expression in Protozoa. The Connection with the PI System

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Book cover Signaling Mechanisms in Protozoa and Invertebrates

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 17))

Abstract

Although the basic structure of biological membranes is provided by the lipid bilayer, most of the specific functions are carried out by proteins. Different membrane proteins are associated with the membrane in different ways. Results suggesting hydrophobic nonprotein anchors, e.g., glycosyl-phosphatidylinositol (GPI) were obtained in studies among others on membrane-bound enzymes, antigens, and cell-surface glycoproteins. It is somewhat surprising that a significant portion of proteins expressed at the cell surface (of both unicellular and higher eukaryotes) via GPI anchors, among others hydrolitic enzymes (e.g., aminopeptidase P, alkaline phosphatase, acetylcholinesterase, lipoprotein lipase); mammalian antigens (e.g., Thy 1, Q a, RT-G, CD 14); protozoal antigens [e.g., variant surface glycoprotein (VSG) (Trypanosoma), temperature-specific 156 G antigen (Paramecium), immobilization antigens (Tetrahymena), 195 kDa antigen (Plasmodium)]; cell adhesion molecules (e.g., N-CAM, heparan sulfate proteoglycan, guinea pig sperm PH20, contact side A (Dictyostelium), and another kind of proteins, such as 34-kDa placental growth factor, decay-accelerating factor (DAF), tegument protein (Schistosoma), 125-kDa glycoprotein (Saccharomyces), etc. (reviewed by Ferguson and Williams 1988).

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Authors and Affiliations

  1. Department of Biology, Semmelweis University of Medicine, P.O. Box 370, 1445, Budapest, Hungary

    P. Kovács

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  1. P. Kovács
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Editors and Affiliations

  1. Department of Biology, Semmelweis University of Medicine, P.O. Box 370, Nagyvárad tér 4, 1445, Budapest, Hungary

    G. Csaba

  2. Institut für Physiologische Chemie Abteilung Angewandte Molekularbiologie, Universität Mainz, Duesbergweg 6, 55099, Mainz, Germany

    W. E. G. Müller

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© 1996 Springer-Verlag Berlin Heidelberg

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Kovács, P. (1996). Cell-Surface GPI Expression in Protozoa. The Connection with the PI System. In: Csaba, G., Müller, W.E.G. (eds) Signaling Mechanisms in Protozoa and Invertebrates. Progress in Molecular and Subcellular Biology, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80106-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-80106-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80108-2

  • Online ISBN: 978-3-642-80106-8

  • eBook Packages: Springer Book Archive

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