Interactions Between CD44 and Hyaluronic Acid: Their Role in Tumor Growth and Metastasis

  • M. S. Sy
  • D. Liu
  • R. Schiavone
  • J. Ma
  • H. Mori
  • Y. Guo
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 213/3)

Abstract

Adhesion molecules enable lymphocytes to interact with antigen-presenting cells or target cells more effectively (Springer 1990; Butcher 1986; Stoolman 1989). Adhesion molecules also allow lymphocytes or monocytes to interact with endothelial cells or high endothelial venules (HEV). Adhesion molecules enable lymphocytes or monocytes to recirculate and home to specific anatomical sites during inflammation. Tumor metastasis is a complex phenomenon involving a sequence of events that remain poorly understood (Fidler 1978; Nicolson 1988; Kahn 1992; Stetler-Stevenson et al. 1993; Turley 1984). Tumor metastatic cascade involves tumor cell and host cell interactions and may also involve interactions among tumor cells. Tumor cells developed in different microenvironments may utilize different mechanisms for invasion and metastasis. This interpretation was supported by results obtained from experiments using orthoptopic implantation of human carcinoma cells in nude mice (Fidler and Radinsky 1990; Fidler et al. 1990). Human colon carcinoma cell lines do not metastasize unless they are injected into the cecum or spleen of nude mice (Fidler 1991). Subcutaneous injection of the same tumor cell lines results in a significantly lower frequency of metastasis formation. These observations have also been observed with human breast, stomach, pancreas, and prostate tumor cell lines (Fidler and Radinsky 1990; Fidler 1990, 1991). In general, orthotopic transplants of human tumors into nude mice favors recapitulation of the metastatic patterns seen in patients with the same tumor.

Keywords

Lymphoma Heparin Fluorescein Neuroblastoma Plasminogen 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. S. Sy
    • 1
    • 2
    • 3
  • D. Liu
    • 1
  • R. Schiavone
    • 1
  • J. Ma
    • 1
  • H. Mori
    • 1
  • Y. Guo
    • 1
    • 3
  1. 1.Institute of Pathology, School of MedicineCase Western Reserve UniversityClevelandUSA
  2. 2.Department of Dermatology, School of MedicineCase Western Reserve UniversityClevelandUSA
  3. 3.Cancer Research Center, School of MedicineCase Western Reserve UniversityClevelandUSA

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