Customized Probability Models for Early Severe Sepsis in Adult Intensive Care Patients

  • J. R. Le Gall
  • S. Lemeshow
  • The ICU Scoring Group
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1996)


The new drugs used in septic patients, such as anti-endotoxins or anti-cytokines, are often very expensive, but studies to evaluate their efficacy are complex and involve heterogeneous groups of patients. Therapeutic trials must be carefully designed to compare the placebo and the treated groups, but in spite of many well-conducted trials, the conclusions are often disappointing [1–3], due either to the inclusion criteria being too liberal or to a lack of stratification of patients by their probability of mortality. The use of probability models could improve such studies by enabling comparison of the two groups by risk of death categories. The aim of this study was to develop models for use in clinical trials of severe sepsis patients identified early in the ICU stay based on the Simplified Acute Physiology Score (SAPS II) [4] or the 24-h model of the Mortality Probability Model (MPM II) system, the MPM II24 [5].


Severe Sepsis Sepsis Patient Acute Physiology Score Organ System Failure Severe Sepsis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. R. Le Gall
  • S. Lemeshow
  • The ICU Scoring Group

There are no affiliations available

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