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Yearbook of Intensive Care and Emergency Medicine pp 197–207Cite as

Intestinal Ischemia/Reperfusion: A Role for Mast Cells and Neutrophils

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Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1996))

Abstract

Reperfusion of ischemic intestine associated with hemorrhage and other shock states is characterized by a number of microvascular and mucosal alterations including endothelial cell swelling, capillary plugging, a prolonged reduction in intestinal blood flow and mucosal barrier dysfunction [1–3]. The intestinal lesion becomes a very important factor in patients recovering from shock inasmuch as loss of a restrictive lumenal barrier is strongly associated with toxic factors entering the circulation and causing sepsis and possibly multiple organ failure [2]. An extensive amount of work has been completed elucidating some of the factors that underlie ischemia/reperfusion (I/R)-induced intestinal dysfunction; alterations in post-ischemic blood flow, reactive oxygen metabolites, various pro-inflammatory mediators, neutrophils and mast cells have all been implicated as potentially contributing to intestinal injury associated with reperfusion [1,2,4–6]. Although each of these factors likely play a role in the pathogenesis of I/R, it is our hypothesis that the recruitment of neutrophils by mast cells is the initiating event that mediates the injury associated with this intestinal condition. In this chapter, we summarize some of the data to implicate neutrophils and mast cells as key mediators of the I/R-induced injury in the small bowel.

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Authors
  1. P. Kubes
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1996 Springer-Verlag Berlin Heidelberg

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Kubes, P. (1996). Intestinal Ischemia/Reperfusion: A Role for Mast Cells and Neutrophils. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_17

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  • DOI: https://doi.org/10.1007/978-3-642-80053-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60552-2

  • Online ISBN: 978-3-642-80053-5

  • eBook Packages: Springer Book Archive

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