Potential Role for Human Interleukin-11 in Bacterial Sepsis

  • S. M. Opal
  • J. C. KeithJr.
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1996)


Human interleukin (IL)-11 was first isolated and characterized by Paul and colleagues in 1990 [1] as one of the essential elements of the hematopoietic microenvironment. It was initially described as a hematopoietic growth factor from stromal bone marrow elements which could support the growth of a plasmacytoma cell line and had profound effects on megakaryocyte growth and development. It was subsequently shown that this is a remarkably pleiotropic cytokine with numerous physiologic attributes affecting hematopoietic and non-hematopoietic cell lines [2]. Recent experimental evidence indicates that IL-11 possesses therapeutic properties which may prove to be beneficial in the prevention and treatment of human sepsis. This chapter will summarize the current knowledge of this important cytokine and describe its potential therapeutic role in the septic patient.


Bacterial Sepsis Hematopoietic Microenvironment Megakaryocyte Growth Bacteremic Infection Streptococcal Sepsis 
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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • S. M. Opal
  • J. C. KeithJr.

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