Interleukin-10 Production during Septic Shock
Human interleukin (IL)-10 is a protein of 160 amino acids (molecular weight: 18.5 kDa) containing two intramolecular disulfide bonds [1, 2]. It is acid-labile and appears in soluble form as a homodimer. The gene encoding IL-10, which is located on chromosome 1 both in mouse and man, contains several noncoding sequences which are thought to control its transcription and the stability of the corresponding mRNA . Several cell types can produce IL-10 including CD4+ and CD8+ T cells, macrophages/monocytes, B cells, keratinocytes, mesangial cells and a variety of tumor cells . In most inflammatory disorders including septic shock, cells of the monocytic lineage represent the major source of IL-10.
KeywordsToxicity Dopamine Adenosine Interferon Prostaglandin
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- 4.Cassatella MA, Meda L, Bonora S, Ceska M, Constantin G (1993) Interleukin-10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes: Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 178: 2207–2211PubMedCrossRefGoogle Scholar
- 9.Mertz PM, Dewitt DL, Stetlerstevenson WG, Wahl LM (1994) Interleukin-10 suppression of monocyte prostaglandin H synthase-2: Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production. J Biol Chern 269: 21322–21329Google Scholar
- 12.Jenkins JK, Malyak M, Arend WP (1994) The effects of interleukin-10 on interleukinreceptor antagonist and interleukin-1β production in human monocytes and neutrophils. Lymphokine Cytokine Res 13: 84–89Google Scholar
- 19.Bean AGD, Freiberg RA, Andrade S, Menon S, Zlotnik A (1993) Interleukin-10 protects mice against staphylococcal enterotoxin B-induced lethal shock. Infect Immunol 61: 4937–4939Google Scholar
- 20.Bermudez LE, Champsi J (1993) Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice. Infect Immunol 61: 3093–3097Google Scholar
- 24.Marchant A, Vincent JL, Goldman M (1996) Interleukin-10 as a protective cytokine produced during sepsis. In: Morrison DC, Ryan JL (eds) Novel therapeutic strategies in the treatment of sepsis. Marcel Decker, New York, pp 301–311Google Scholar
- 26.van der Poll T, Marchant A, Buurman W, et al (1996) Endogenous interleukin-10 protects mice from death during septic peritonitis. J Immunol (In press)Google Scholar
- 30.Marchant A, Alegre ML, Hakim A, et al (1996) Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol (In press)Google Scholar
- 37.Bourrie B, Bouaboula, Benoit JM, Derocq JM, Esclangon M, Casellas P (1995) Enhancement of endotoxin-induced anti-inflammatory cytokine IL10 production by the sigma ligand SR31747. 9th International Congress of Immunology, San Francisco: 897 (Abst)Google Scholar