Interleukin-10 Production during Septic Shock
Human interleukin (IL)-10 is a protein of 160 amino acids (molecular weight: 18.5 kDa) containing two intramolecular disulfide bonds [1, 2]. It is acid-labile and appears in soluble form as a homodimer. The gene encoding IL-10, which is located on chromosome 1 both in mouse and man, contains several noncoding sequences which are thought to control its transcription and the stability of the corresponding mRNA . Several cell types can produce IL-10 including CD4+ and CD8+ T cells, macrophages/monocytes, B cells, keratinocytes, mesangial cells and a variety of tumor cells . In most inflammatory disorders including septic shock, cells of the monocytic lineage represent the major source of IL-10.
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