Properties of an STR multiplex marker system suitable for paternity and forensic determinations
Simple sequence repeat polymorphisms composed of tandem di-,tri- or tetranucleotide repeats (STR) are highly abundant in the human genome (Williamson et al. 1990) and are particularly suitable for detection by PCR amplification. These type of loci have been used for population genetic studies, determination of paternity or forensic analysis (Edwards et al. 1991, Kimpton et al. 1993). Analysis of these markers has been performed either by individual amplification of single loci or by the simultaneous amplification of several loci (i.e. multiplexing). Alleles can be detected by gel electrophoresis followed by radioactive labeling, silver staining or fluorescence detection.
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