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Inhaled Nitric Oxide: A Review

  • Chapter
Role of Nitric Oxide in Sepsis and ADRS

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 24))

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Abstract

Severe hypoxemia and concurrent pulmonary hypertension can complicate the treatment of acute respiratory failure in neonates and adults. Attempts to treat the pulmonary hypertension with pulmonary vasodilators have been limited by systemic hypotension and worsening of arterial hypoxemia secondary to altered ventilation/perfusion matching [1–3]. Recently, inhaled nitric oxide (NO) was noted to selectively vasodilate the pulmonary circulation [4–6]. Significant systemic hypotension did not occur because NO is inactivated by rapid binding to hemoglobin in the blood. Inhaling NO often improves the systemic arterial oxygen tension in patients with severe acute lung injury (ALI) and pulmonary hypertension [7, 8]. Inhaled NO is receiving intense and widespread examination throughout the world for treating severe hypoxemia and pulmonary hypertension.

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Authors
  1. W. M. Zapol
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  2. W. E. Hurford
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Editors and Affiliations

  1. Department of Surgery, Beth Israel Hospital, 330 Brookline Avenue, 02215, Boston, MA, USA

    M. P. Fink

  2. Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France

    Didier Payen

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Zapol, W.M., Hurford, W.E. (1995). Inhaled Nitric Oxide: A Review. In: Fink, M.P., Payen, D. (eds) Role of Nitric Oxide in Sepsis and ADRS. Update in Intensive Care and Emergency Medicine, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79920-4_21

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  • DOI: https://doi.org/10.1007/978-3-642-79920-4_21

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