Nitric Oxide as a Mediator of Hypotension and Inflammation in Sepsis

  • R. L. Danner
  • J. Cobb
  • A. L. Van Dervort
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 24)


Septic shock is a severe systemic inflammatory response caused by infection with any of a wide variety of microorganisms. Clinically, it is characterized by fever, hypotension, and signs of organ hypoperfusion or dysfunction. The high mortality rate of septic shock, despite the administration of effective antimicrobial agents, fluids, and catecholamine vasopressors, has led to an extensive effort to identify the microbial products, host mediators, and cell- activation mechanisms that trigger and fuel the clinical manifestations of this syndrome. As a result of this effort, our understanding of septic shock has grown exponentially. However, although therapies targeting newly discovered pathogenic mechanisms have been developed, none have as yet demonstrated clinical efficacy [1], One of the most interesting mediators recently implicated in septic shock is nitric oxide (NO).


Nitric Oxide Nitric Oxide Septic Shock Mean Arterial Pressure Human Neutrophil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • R. L. Danner
  • J. Cobb
  • A. L. Van Dervort

There are no affiliations available

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