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Platelet Regulation and Damage in Vascular Thrombotic and Septic Disorders

  • Chapter
Role of Nitric Oxide in Sepsis and ADRS

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 24))

Abstract

The discovery of the endogenous pathway for biosynthesis of nitric oxide (NO) from L-arginine and the appreciation that this mediator regulates riot only vascular tone but also platelet function have resulted in revisiting the physiological regulation of vascular hemostasis [1]. In this chapter, we will describe the basis for this regulation in health and review how the changes in the release, metabolism and action of NO may be involved in the pathogenesis of vascular pathologies including septicemia, thrombosis and atherosclerosis.

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Authors
  1. M. W. Radomski
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  2. E. Salas
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Editors and Affiliations

  1. Department of Surgery, Beth Israel Hospital, 330 Brookline Avenue, 02215, Boston, MA, USA

    M. P. Fink

  2. Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France

    Didier Payen

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Radomski, M.W., Salas, E. (1995). Platelet Regulation and Damage in Vascular Thrombotic and Septic Disorders. In: Fink, M.P., Payen, D. (eds) Role of Nitric Oxide in Sepsis and ADRS. Update in Intensive Care and Emergency Medicine, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79920-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-79920-4_10

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