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DNA Immunization in an Arenavirus Model

  • Conference paper
Symposium in Immunology V

Abstract

Viral infections remain major causes of human morbidity and mortality, and therapy of ongoing infection remains in most cases elusive. Prophylaxis, however, has been dramatically effective; vaccination has eradicated smallpox and has diminished the incidence of the more severe viral infections (mumps, rubella, measles, and polio) at least in the “developed” countries. Nevertheless, in “underdeveloped” countries these diseases, and the consequent morbidity and mortality, remain problematic. For example, measles virus infections in the Third World lead directly (via viral encephalitis or giant-cell pneumonia) or indirectly (via bacterial superinfection) to an estimated 1–2 million deaths per year. Furthermore, since the appearance of HIV the contribution of viruses to human suffering has escalated greatly, and this will only increase. The search for an HIV vaccine drives much of the current effort to dissect the antiviral immune response molecularly.

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Authors
  1. J. L. Whitton
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  2. M. Yokoyama
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  3. J. Zhang
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Editor information

Editors and Affiliations

  1. Institut für Immunologie, Universität Wien, Borschkegasse 8 a, 1090, Wien, Austria

    Martha M. Eibl

  2. Department of Hematology, Johannes Gutenberg Universität, Langenbeckstr. 1, 55131, Mainz, Germany

    Christoph Huber

  3. Abteilung für Rheumatologie und Klinische Immunologie, Medizinische Universitätsklinik, Hugstetter Str. 55, 79106, Freiburg, Germany

    Hans H. Peter

  4. Pädiatrische Pneumologie und Immunologie, Universitäts-Klinikum Rudolf-Virchow Standort Charlottenburg, Heubnerweg 6, 14059, Berlin, Germany

    Ulrich Wahn

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© 1996 Springer Verlag Berlin Heidelberg

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Whitton, J.L., Yokoyama, M., Zhang, J. (1996). DNA Immunization in an Arenavirus Model. In: Eibl, M.M., Huber, C., Peter, H.H., Wahn, U. (eds) Symposium in Immunology V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79896-2_14

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  • DOI: https://doi.org/10.1007/978-3-642-79896-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60061-9

  • Online ISBN: 978-3-642-79896-2

  • eBook Packages: Springer Book Archive

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