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Neurobiochemie suizidalen Verhaltens

  • Conference paper
Suizidalität

Part of the book series: Tropon-Symposium ((BAYERZNS,volume 10))

Zusammenfassung

Die biochemische Suizidforschung ist aus der biochemischen Depressions-forschunghervergegangen.Di Quantifizierung von Neurotransmittermetaboliten in der Zerebrospinalflüssigkeit depressiver bzw, suizidaler Patienten, aber auch für den Versuch, leichter zugängliche periphere Parameter für die Diagnostik nutzbar zu machen. Von Anfang an war die vorrangige Rolle des Neurotransmitters Serotonin im Zusammenhang mit suizidalem Verhalten deutlich; auch heute noch konzentriert sich die Fosrchung insbesondere auf die serotoninbezogenen Parameter einschlieβlich der Rezeptoren, Metaboliten und biochemischen Vorstufen. Seit Beggin der neunziger Jahre gewinnen aber auch andere, speziell adrenerge, Parameter zuhnemendes Interesse. Die laborchemische Testung auf eine Suizidneigung ist sicher noch eine Zukunftsvision, jedoch wurden bereits erste Versuche mit klinisch-praktisch anwendbaren Kombinationtests aus Spontaparametern und Funktiontests unternommen. Fernziel ist dabei die Ermittlung eines objektiven, biochemischen Suizidindexes.

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Literatur

  • Arango V, Ernsberger P, Marzuk PM et al. (1990) Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiatry 47 (Supplii): 1038–1047

    Article  PubMed  CAS  Google Scholar 

  • Arango V, Underwood MD, Mann J J (1992) Alterations in monomine receptors in the brain of suicide victims. J Clin Psychopharmacol 12: 8S–12S

    Article  PubMed  CAS  Google Scholar 

  • Arango V, Ernsberger P, Sved AF, Mann J J (1993) Quantitative autoradiography of alphar and alpha2-adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Res 630: 271–282

    Article  PubMed  CAS  Google Scholar 

  • Arato M, Tekes K, Tothfalusi L, Magyar K, Palkovits M, Demeter E, Falus A (1987) Serotonergic split brain and suicide. Psychiatry Res 21: 355–356

    Article  PubMed  CAS  Google Scholar 

  • Artaó M, Tekes K, Tothfalusi L et al. (1991) Reversed hemispheric asymmertry of imipramine binding in suicide victims. Biol Psychiatry 29: 699–702

    Article  Google Scholar 

  • Arora RC, Meitzer HY (1989a) 3H-imipramine binding in the frontal cortex of suicides. Psychiatry Res 30: 125–135

    Google Scholar 

  • Arora RC, Meitzer HY (1989b) Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. Am J Psychiatry 146: 730–736

    PubMed  CAS  Google Scholar 

  • Arora RC, Meltzer HY (1991) Laterality and 3H-imipramine binding: studies in the frontal cortex of normal controls and suicide victims. Biol Psychiatry 29 (Suppl 10): 1016–1022

    Article  PubMed  CAS  Google Scholar 

  • Arora RC, Meltzer HY (1993) Serotonin2 receptor binding in blood platelets of schizophrenic patients. Psychiatry Res 47: 111–119

    Article  PubMed  CAS  Google Scholar 

  • Arranz B, Cowburn R, Eriksson A, Vestling M, Marcusson J (1992) Gamma-aminobutyric acid-B ( GABAb) binding sites in postmortem suicide brains. Neuropsychobiology 26: 33–36

    Google Scholar 

  • Arranz B, Eriksson A, Mellerup E, Plenge P, Marcusson J (1994) Brain 5-HTIA, 5-HTID, and 5-HT2 receptors in suicide victims. Biol Psychiatry 35: 457–463

    Article  PubMed  CAS  Google Scholar 

  • Åsberg M, Thorén P, Träskman L, Bertilsson L, Ringberger V (1976a) „Serotonin depression“– a biochemical subgroup within the affective disorders? Science 191: 478–480

    Google Scholar 

  • Åsberg M, Träskman L, Thorén P (1976b) 5-HIAA in the cerebrospinal fluid - a biochemical suicide predictor? Arch Gen Psychiatry 33: 1193–1197

    Google Scholar 

  • Åsberg M, Schalling D, Träskman-Bendz L, Wägner A (1987) Psychobiology of suicide, impulsivity, and related phenomena. In: Meitzer HY (ed) Psychopharmacology. The third generation of progress. Raven Press, New York, pp 655–668

    Google Scholar 

  • Ashcroft GW, Sharman DF (1960) 5-hydroxyindoles in human cerebrospinal fluids. Nature 186: 1050–1051

    Google Scholar 

  • Aschcroft GW, Crawford TBB, Eccleston D, Sharman DF, McDougall EJ, Stanton JB, Binns JK (1966) 5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases. Lancet II: 1049–1052

    Google Scholar 

  • Banki CM, Molnar G, Vojnik M (1981) Cerebrospinal fluid amine metabolites, tryptophan and clinical parameters in depression. J Affect Disord 3: 91–99

    Article  PubMed  CAS  Google Scholar 

  • Banki CM, Arato M, Papp Z, Kurcz M (1984) Biochemical markers in suicidal patients. Investigations with cerebrospinal fluid amine metabolites and neuroendocrine tests. J Affect Discord 6 (3-4): 341–350

    Article  CAS  Google Scholar 

  • Banki CM, Vojnik M, Papp Z, Balla KZ, Arato M (1985) Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts. Biol Psychiatry 20: 163–171

    Article  PubMed  CAS  Google Scholar 

  • Beck-Friis J, Kjellman F, Aperia B, Unden F, Rosen D, Ljunggren J-G, Wetterberg L (1985) Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand 71: 319–330

    Article  PubMed  CAS  Google Scholar 

  • Beckmann H (1978) Biochemische Grundlagen der endogenen Depression. Nervenarzt 49: 557–568

    PubMed  CAS  Google Scholar 

  • Beskow J, Gottfries CG, Roos BE, Winblad B (1976) Determination of monoamine and monoamine metabolites in the human brain: post mortem studies in a group of suicides and in a control group. Acta Psychiatr Scand 53: 7–20

    Article  PubMed  CAS  Google Scholar 

  • Biegon A, Fieldust S (1992) Reduced tyrosin hydroxylase immunoreactivity in locus coeruleus of suicide victims. Synapse 10: 79–82

    Article  PubMed  CAS  Google Scholar 

  • Biegon A, Israeli M (1988) Regionally selective increases in beta-adrenergic receptor density in the brains of suicide victims. Brain Res 442: 199–203

    Article  PubMed  CAS  Google Scholar 

  • Biegon A, Weizman A, Karp L, Ram A, Tiano S, Wolff M (1987) Serotonin 5-HT2 receptor binding on blood platelets - a peripheral marker for depression? Life Sei 41: 2485–2492

    Article  CAS  Google Scholar 

  • Biegon A, Grinspoon A, Blumenfeld B, Bleich A, Apter A, Mester R (1990) Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men. Psychopharmacology 100: 165–167

    Article  PubMed  CAS  Google Scholar 

  • Bourne HR, Bunney WE, Colburn RW, Davis JM, Davis JN, Shaw DM, Coppen AJ (1968) Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients. Lancet II: 805–808

    Google Scholar 

  • Bräunig P, Pollentier S, Rao ML (1988) Increased serotonin after a suicide attempt: coincidence or catharsis? Biol Psychiatry 24: 725–727

    Article  PubMed  Google Scholar 

  • Bräunig P, Rao ML, Fimmers R (1989) Blood serotonin levels in suicidal schizophrenic patients. Acta Psychiatr Scand 79: 186–189

    Article  PubMed  Google Scholar 

  • Brewerton TD, Berrettini WH, Nürnberger JI, Linnoila M (1988) Analysis of seasonal fluctuations of CSF monoamine metabolites and neuropeptides in normal controls: findings with 5-HIAA and HVA. Psychiatry Res 23: 257–265

    Article  PubMed  CAS  Google Scholar 

  • Briley M, Langer SZ, Raisman R, Sechter D, Zarifian E (1980) Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 109: 303–305

    Article  Google Scholar 

  • Brown DL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK (1982) Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 139: 741–746

    PubMed  CAS  Google Scholar 

  • Buchsbaum MS, Haier RJ, Murphy DL (1977) Suicide attempts, platelet monoamine oxidase and the average evoked response. Acta Psychiatr Scand 56: 69–79

    Article  PubMed  CAS  Google Scholar 

  • Bunney WE, Fawcett JA (1965) Possibility of a biochemical test for suicidal potential. Arch Gen Psychiatry 13: 232–239

    Article  PubMed  CAS  Google Scholar 

  • Bunney WE, Fawcett JA, Davis JM, Gifford S (1969) Further evalutaion of urinary 17-hydroxy- corticosteroids in suicidal patients. Arch Gen Psychiatry 21: 138–150

    Article  PubMed  Google Scholar 

  • Cheetham SC, Crompton MR, Katona SLE, Horton RW (1988) Brain 5-HT2 receptor binding sites in depressed suicide victims. Brain Res 443: 272–280

    Article  PubMed  CAS  Google Scholar 

  • Cheetham SC, Crompton MR, Katona CLE, Horton RW (1990) Brain 5-HT, binding sites in depressed suicides. Psychopharmacology 102: 544–548

    Article  PubMed  CAS  Google Scholar 

  • Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, Mohs RC, Davis KL (1989) Serotonergic studies in patients with affective and personality disorders. Arch Gen Psychiatry 46: 587–599

    Article  PubMed  CAS  Google Scholar 

  • Cochran E, Robins E, Grote S (1976) Regional serotonin levels in brain: a comparison of depressive suicides and alcoholic suicides with controls. Biol Psychiatry 11: 283–294

    PubMed  CAS  Google Scholar 

  • Coppen A (1967) The biochemistry of affective disorders. Br J Psychiatry 113: 1237–1264

    Article  PubMed  CAS  Google Scholar 

  • Coppen A, Eccleston EG, Peet M (1972) Total and free tryptophan concentration in the plasma of depressive patients. Lancet II: 1415–1416

    Google Scholar 

  • Corrigan MH, Gillette GM, Quade D, Garbutt JC (1992) Panic, suicide, and agitation: independent correlates of the TSH response to TRH in depression. Biol Psychiatry 31: 984–992

    Article  PubMed  CAS  Google Scholar 

  • Crow TJ, Cross AJ, Cooper SJ et al. (1984) Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 23: 1561–1569

    Article  PubMed  CAS  Google Scholar 

  • Dajas F, Barbeito L, Cervenansky C (1986) An association between norepinephrine-to-epinephrine ratio and suicidal ideation in depression. Am J Psychiatry 143: 683–684

    Google Scholar 

  • Da Prada M, Cesura AM, Launay JM, Richards JG (1988) Platelets as a model for neurones? Experientia 44: 115–126

    Article  PubMed  Google Scholar 

  • De Leo D, Caneva A, Marazziti D, Conti L (1991) Platelet imipramine binding in intensive care unit suicidal patients. Eur Arch Psychiatry Clin Neurosci 241: 85–87

    Article  PubMed  Google Scholar 

  • Demling J, Langer K, Thum U, Sprang A van (1992) Plasmaaminosäuren und Suizidalität. Eine Studie unter spezieller Berücksichtigung von Tryptophan. Nervenheilkunde 11: 344–349

    Google Scholar 

  • Demling J, Langer K, Wörthmüller M, Yusufu V (1993) Individual day-to-day variations of plasma amino acid levels in healthy persons. Amino Acids 5: 253–262

    Article  CAS  Google Scholar 

  • DeMyer MK, Shea PA, Hendrie HC, Yoshimura NN (1981) Plasma tryptophan and five other amino acids in depressed and normal subjects. Arch Gen Psychiatry 38: 642–646

    Article  PubMed  CAS  Google Scholar 

  • De Paermentier F, Cheetham SC, Crompton MR, Katona CLE, Horton RW (1990) Brain ß-adrenoceptor binding sites in antidepressant-free depressed suicide victims. Brain Res 525: 71–77

    Article  PubMed  Google Scholar 

  • Dillon KA, Gross-lsseroff R, Israeli M, Biegon A (1991) Autoradiographic analysis of serotonin 5-HTIA receptor binding in the human brain postmortem: effects of age and alcohol. Brain Res 554: 56–64

    Article  PubMed  CAS  Google Scholar 

  • Duits N, Bos FM (1993) Psychiatrische stoonissen bij simvastatine-gebruik. Ned-Tijdsch-Geneeskd 137: 1312–1315

    CAS  Google Scholar 

  • Engelberg H (1992) Low serum cholesterol and suicide. Lancet 339: 727–729

    Article  PubMed  CAS  Google Scholar 

  • Engelhardt A, Oheim S, Neundörfer B (1992) Post-lumbar puncture headache: experiences with Sprotte’satraumatic needle. Cephalalgia 12: 259

    Article  PubMed  CAS  Google Scholar 

  • Garelis E, Young SN, Lai S, Sourkes TL (1974) Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies. Brain Res 79: 1–8

    Article  PubMed  CAS  Google Scholar 

  • Gjerris A (1988) Do concentrations of neurotransmitters in lumbar CSF reflect cerebral dysfunction in depression? Acta Psychiatr Scand 78 (Suppl 345): 21–24

    Article  Google Scholar 

  • Golden RN, Filmore JH, Corrigan MHN, Ekstrom RD, Knight BT, Garbutt JC (1991) Serotonin, suicide, and aggression: clinical studies. J Clin Psychiatry 52 (Suppl 12): 61–69

    PubMed  Google Scholar 

  • González AM, Pascual J, Meana JJ, Barturen F, del Arco C, Pazos A, Garcia-Sevilla JA (1994) Autoradiographic demonstration of increased α2- adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims. J Neurochem 63: 256–265

    Article  PubMed  Google Scholar 

  • Gottfries CG, Oreland L, Wiberg A, Winblad B (1975) Lowered monoamine oxidase activity in brains from alcoholic suicides. J Neurochem 25: 667–673

    Article  PubMed  CAS  Google Scholar 

  • Gottfries C-G, Knorring LV, Oreland L (1980) Platelet monoamine oxidase acitivity in mental disorders. 2. Affective psychosis and suicidal behavior. Prog Neuropsychopharmacol 4: 185–192

    Google Scholar 

  • Gross-lsseroff R, Israeli M, Biegon A (1988) Autoradiographic analysis of [3H]desmethylimipramine binding in the human brain postmortem. Brain Res 456 (1): 120–126

    Article  PubMed  CAS  Google Scholar 

  • Gross-lsseroff R, Israeli M, Biegon A (1989) Autoradiographic analysis of tritiated imipramine binding in the human brain post mortem: effects of suicide. Arch Gen Psychiatry 46: 237–241

    Article  Google Scholar 

  • Gross-lsseroff R, Salama D, Israeli M, Beigon A (1990a) Autoradiographic analysis of (3H)ketanserin binding in the human brain postmortem: effect of suicide. Brain Res 507: 208–215

    Article  PubMed  CAS  Google Scholar 

  • Gross-Isseroff R, Dillon KA, Fieldust SJ, Biegon A (1990b) Autoradiographic analysis of α1-noradrenergic receptors in the human brain postmortem. Effect of suicide. Arch Gen Psychiatry 47: 1049–1053

    Google Scholar 

  • Grote SS, Moses SG, Robins E, Hudgens RW, Croninger AB (1974) A study of selected catecholamine metabolizing enzymes: a comparison of depressive suicides and alcoholic suicides with controls. J Neurochem 23: 791–802

    Article  PubMed  CAS  Google Scholar 

  • Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56–62

    Article  PubMed  CAS  Google Scholar 

  • Hawton K, Cowen P, Owens D, Bond A, Elliott M (1993) Low serum cholesterol and suicide. Br J Psychiatry 162: 818–825

    Article  Google Scholar 

  • Hrdina PD, Demeter E, Vu TB, Sotonyi P, Palkovits M (1993) 5-HT2 uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain Res 614: 37–44

    Google Scholar 

  • Joyce JN, Lexow N, Kim SJ et al. (1992) Distribution of beta-adrenergic receptor subtype in human post- Mortem brain: alterations in limbic regions of schizophrenia. Synapse 10: 228–246

    Article  PubMed  CAS  Google Scholar 

  • Kauert G, Zucker T, Gilg T, Eisenmenger W (1986) Measurements of biogenic amines and metabolites in the CSF of suicide victims and nonsuicides. In: Möller H-J, Schmidtke A, Welz R (eds) Current issues of suicidology. Springer, Berlin Heidelberg New York, pp 252–262

    Google Scholar 

  • Kaufmann CA, Gillin JC, Hill B, O’Laughlin T, Philips I, Kleinman JE, Wyatt RJ (1984) Muscarinic binding in suicides. Psychiatry Res 12: 47–55

    Article  PubMed  CAS  Google Scholar 

  • Kempen GM J van, Notten P, Hengeveld MW (1992) Repeated measures of platelet MAO activity and 5- HT in a group of suicidal women. Biol Psychiatry 31: 529–530

    Article  PubMed  Google Scholar 

  • Kjellman BF, Ljunggren J-G, Bech-Friis J, Wetterberg L (1985) Effect of TRH on TSH and prolactin levels in affektive disorders. Psychiatry Res 14: 353–363

    Article  PubMed  CAS  Google Scholar 

  • Klompenhouwer JL, Fekkes D, Hülst AM, Molemann P, Pepplinkhiuzen L, Mulder PGH (1990) Seasonal variation in binding of 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference. Biol Psychiatry 28: 509–517

    Article  PubMed  CAS  Google Scholar 

  • Korn ML, Asnis G, Brown SL, van Praag HM (1992) Serotonin receptor sensitivity and suicide. Biol Psychiatry 32: 207–213

    Article  Google Scholar 

  • Korpi ER, Kleinman JE, Goodman SI, Philips I, DeLisi LE, Linnoila M, Wyatt RJ (1986) Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death. Arch Gen Psychiatry 43: 594–600

    Google Scholar 

  • Korpi ER, Kleinman JE, Wyatt RJ (1988) GAB A concentrations in forebrain areas of suicide victims. Biol Psychiatry 23: 109–114

    Article  PubMed  CAS  Google Scholar 

  • Krieger G (1974) The plasma level of Cortisol as a predictor of suicide. Dis Nerv Syst 35: 237–240

    PubMed  CAS  Google Scholar 

  • Kruesi MJP (1989) Cruelty to animals and CSF 5-HIAA. Psychiatry Res 28: 115–116

    Article  PubMed  CAS  Google Scholar 

  • Kuhn DM, Wolf WA, Youdim MBH (1986) Serotonin neurochemistry revisited: a new look at some old axioms. Neurochem Int 8: 141–154

    Article  PubMed  CAS  Google Scholar 

  • Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberger DR, Kleinman JE (1993) Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study. Arch Gen Psychiatry 50 (10): 810–818

    Article  PubMed  CAS  Google Scholar 

  • Lawrence KM, De Paermentier F, Cheetham SC, Crompton MR, Katona CLE, Horton RW (1990a) Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides. Brain Res 526: 17–22

    Article  PubMed  CAS  Google Scholar 

  • Lawrence KM, De Paermentier F, Cheetham SC, Crompton MR, Katona CLE, Horton RW (1990b) Symmetrical hemispheric distribution of 3H-paroxetine binding sites in postmortem human brain from controls and suicides. Biol Psychiatry 28: 544–546

    Article  PubMed  CAS  Google Scholar 

  • Leckman JF, Goodman WK, Riddle MA, Hardin MT, Anderson GM (1990) Low CSF 5-HIAA and obsessions of violence: report of two cases. Psychiatry Res 33: 95–99

    Article  PubMed  CAS  Google Scholar 

  • Lester D (1992) The dexamethasone suppression test as an indicator of suicide: a meta-analysis. Pharmacopsychiatry 25: 265–270

    Article  PubMed  CAS  Google Scholar 

  • Lidberg L, Åsberg M, Sundqvist-Stensman UB (1984) 5-hydroxy-indoleacetic acid levels in attempted suicides who have killed their children. Lancet II: 928

    Google Scholar 

  • Linkowski P, van Wettere JP, Kerkhofs M, Brauman H, Mendlewicz J (1983) Thyrotropin response to thyreostimulin in affectively ill women: relationship to suicidal behavior. Br J Psychiatry 143: 401–405

    Article  PubMed  CAS  Google Scholar 

  • Linkowski P, Wettere JP van, Kerkhofs M, Gregoire F, Braumann H, Mendlewicz J (1984) Violent suicidal behavior and the thyrotropin-releasing hormone - thyroid-stimulating hormone test: a clinical outcome study. Neuropsychobiology 12: 19–22

    Article  PubMed  CAS  Google Scholar 

  • Linnolia M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK (1983) Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sei 33: 2609–2614

    Article  Google Scholar 

  • Lloyd KG, Farley IJ, Deck JHN, Hornykiewicz O (1974) Serotonin and 5- hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Adv Biochem Psychopharmacol 11: 387–397

    PubMed  CAS  Google Scholar 

  • Lopez-Ibor JJ, Lana F, Saiz-Ruiz J (1990) Impulsive suicidal behavior and serotonin. Actas Luso Esp Neurol Psiquiatr Cienc Afines 18: 316–325

    PubMed  Google Scholar 

  • Lowther S, de Paermentier F, Crompton MR, Katona CLE, Horton RW (1994) Brain 5-HT2 receptors in suicide victims: violence of death, depression and effects of antidepressant treatment. Brain Res 642: 281–289

    CAS  Google Scholar 

  • Maes M, Vandewoude M, Schotte C, Martin M, Blockx P, Schärpe S, Cosyns P (1989) Hypothalamic- pituitary-adrenal and -thyroid axis dysfunctions and decrements in the availability of L-tryptophan as biological markers of suicidal ideation in major depressed females. Acta Psychiatr Scand 80: 13–17

    Article  PubMed  CAS  Google Scholar 

  • Mancini C, Brown GM (1992) Urinary catecholamines and Cortisol in parasuicide. Psychiatry Res 43: 31–42

    Article  PubMed  CAS  Google Scholar 

  • Mann JJ, Stanley M (1984) Postmortem monoamine oxidase enzyme kinetics in the frontal cortex of suicide victims and controls. Acta Psychiatr Scand 69: 135–139

    Article  PubMed  CAS  Google Scholar 

  • Mann JJ, Stanley M, McBride A, McEwen B (1986) Increased serotonin2 and ß-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry 43: 954–959

    Article  PubMed  CAS  Google Scholar 

  • Mann JJ, McBride PA, Anderson GM, Mieczkowski TA (1992a) Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and life-time psychopathology. Biol Psychiatry 32: 243–257

    Article  PubMed  CAS  Google Scholar 

  • Mann JJ, McBride PA, Brown RP et al. (1992b) Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 49: 442–446

    Article  PubMed  CAS  Google Scholar 

  • Marazziti D, Conti L (1991) Aggression and suicide attempts: preliminary data. Eur Neuropsycho- pharmacol 1 (2): 169–172

    Article  CAS  Google Scholar 

  • Marazziti D, De Leo D, Conit L (1989) Further evidence supporting the role of the serotonin system in suicidal behavior: a preliminary study of suicide attempters. Acta Psychiatr Scant 80: 322–324

    Article  CAS  Google Scholar 

  • Matsubara S, Arora RC, Meitzer HY (1991) Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims. J Neural Transm [GenSect] 85: 181–194

    Article  CAS  Google Scholar 

  • McBride PA, Mann J J, McEwen B, Biegon A (1983) Characterization of serotonin binding sites on human platelets. Life Sei 33: 2033–2041

    Article  CAS  Google Scholar 

  • McBride PA, Brown RP, deMeo M, Keilp J, Mieczkowski T, Mann J J (1994) The relationship of platelet 5-HT2 receptor indices to major depressive disorder, personality traits, and suicidal behavior. Biol Psychiatry 35 (5): 295–308

    Article  PubMed  CAS  Google Scholar 

  • Meana J J, Barturen F, Garcia-Sevilla JA (1992) Alpha2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression. Biol Psychiatry 31: 471–490

    Article  PubMed  CAS  Google Scholar 

  • Meana JJ, Barturen F, Martin I, Garcia-Sevilla JA (1993) Evidence of increased non-adrenoceptor [3H]idazoxan binding sites in the frontal cortex of depressed suicide victims. Biol Psychiatry 34: 498–501

    Article  PubMed  CAS  Google Scholar 

  • Meltzer HY, Arora RC (1986) Platelet markers of suicidality. Ann NY Acad Sci 487: 271–280

    Article  PubMed  CAS  Google Scholar 

  • Meltzer HY, Perline R, Tricou BJ, Lowy M, Robertson A (1984) Effect of 5-hydroxytryptophan on serum Cortisol levels in major affective disorders. Arch Gen Psychiatry 43: 379–387

    Article  Google Scholar 

  • Meyerson LR, Wennogle LP, Abel MS, Coupet J, Lippa AS, Rauh CE, Beer B (1982) Human brain receptor alterations in suicide victims. Pharmacol Biochem Behav 17: 159–163

    Article  PubMed  CAS  Google Scholar 

  • Modai I, Apter A, Meitzer M, Tyano S, Walevski A, Jerushalmy Z (1989) Serotonin uptake by platelets of suicidal and aggressive adolescent psychiatric inpatients. Neuropsychobiology 21: 9–13

    Article  PubMed  CAS  Google Scholar 

  • Montero D, Ofori-Adjei D, Wägner A (1989) Circadian variation of platelet 3H-imipramine binding, platelet serotonin content, and plasma Cortisol in healthy volunteers. Biol Psychiatry 26: 794–804

    Article  PubMed  CAS  Google Scholar 

  • Nässberger L, Träskman-Bendz L (1993) Increased soluble interelukin-2 receptor concentrations in suicide attempters. Acta Psychiatr Scand 88: 48–52

    Article  PubMed  Google Scholar 

  • Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M (1988) Reduced corticotropin releasing factor blinding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry 45: 577–579

    Article  PubMed  CAS  Google Scholar 

  • Ohmori T, Arora RC, Meitzer HY (1992) Serotonergic measures in suicide brain: the concentration of 5-HIAA,HVA, and tryptophan in frontal cortex of suicide victims. Biol Psychiatry 32 (1): 57–71

    Article  PubMed  CAS  Google Scholar 

  • Ordway GA, Widdowson PS, Smith KS, Halaris A (1994a) Agonist binding to alpha2-adrencoceptors is elevated in the locus coeruleus from victims of suicide. J Neurochem 63: 617–624

    Article  PubMed  CAS  Google Scholar 

  • Ordway GA, Smith KS, Haycock JW (1994b) Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims. J Neurochem 62: 680–685

    Article  PubMed  CAS  Google Scholar 

  • Oreland L, Wiberg A, Asberg M et al. (1981) Platelet MAO acitivity and monoamine metabolites in cerebrospinal fluid in depression and suicidal patients and in healthy controls. Psychiatry Res 4: 21–29

    Article  PubMed  CAS  Google Scholar 

  • Ostroff R, Giller E, Bonese K, Ebersole E, Harkness L, Mason J (1982) Neuroendocrine risk factors of suicidal behavior. Am J Psychiatry 139: 1323–1325

    PubMed  CAS  Google Scholar 

  • Ostroff R, Giller E, Harkness L, Mason J (1985) The norepinephrine-to-epinephrine ratio in patients with a history of suicide attempts. Am J Psychiatry 142: 224–227

    PubMed  CAS  Google Scholar 

  • Owen F, Cross AJ, Crow TJ, Deakin JFW, Ferner IN, Lofthouse R, Poulter M (1983) Brain 5-HT2 receptors and suicide. Lancet II: 1256

    Google Scholar 

  • Owen F, Chambers DR, Cooper SJ, Crow TJ, Johnson JA, Lofthouse R, Poulter M (1986) Serotonergic mechanisms in brains of suicide victims. Brain Res 326: 185–188

    Article  Google Scholar 

  • Pandey GN, Pandey SC, Janicak PG, Marks RC, Davis JM (1990) Platelet serotonin-2-receptor binding sites in depression and suicide. Biol Psychiatry 28: 215–222

    Article  PubMed  CAS  Google Scholar 

  • Pare CMB, Yeung DPH, Price K, Stacey RS (1969) 5-hydroxy-tryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coalgas poisoning. Lancet II: 133–135

    Google Scholar 

  • Pitchot W, Hansenne M, Gonzalez Moreno A, Ansseau M (1992) Suicidal behavior and growth hormone response to apomorphine test. Biol Psychiatry 31: 1213–1219

    Article  PubMed  CAS  Google Scholar 

  • Pitchot W, Ansseau M, Gonzalez Moreno A, Wauthy J, Hansenne M, Frenckell R (1993) Relationship between alpha2-adrenergic function and suicidal behavior in depressed patients. Psychiatry Res 52: 115–123

    Article  Google Scholar 

  • Pollin W, Cardon PV, Kety SS (1960) Effects of amino acid feedings in schizophrenic patients treated with iproniazid. Science 133: 104–105

    Article  Google Scholar 

  • Praag HM van (1983) CSF 5-HIAA and suicide in non-depressed schizophrenics. Lancet II: 977–978

    Google Scholar 

  • Prasad AJ (1985) Neuroendocrine differences between violent and non-violent parasuicides. Neuro- psychobiology 13: 157–159

    CAS  Google Scholar 

  • Rochet T, Kopp N, Vedrinne J, Deluermoz S, Debilly G, Miachon S (1992) Benzodiazepine binding sites and their modulators in hippocampus of violent suicide victims. Biol Psychiatry 32: 922–931

    Article  PubMed  CAS  Google Scholar 

  • Roy A (1993) Neuropeptides in relation to suicidal behavior in depression. Neuropsychobiology 28: 184–186

    Article  PubMed  CAS  Google Scholar 

  • Roy A, Ninan P, Mazonson A, Pickar D, van Kämmen D, Linnoila M, Paul SM (1985) CSF monoamine metabolites in chronic schizophrenic patients who attempt suicide. Psychol Med 15: 335–340

    Article  PubMed  CAS  Google Scholar 

  • Roy A, Karoum F, Pollack S (1992) Marked reduction in indexes of dopamine metabolism among patients with depression who attempt suicide. Arch Gen Psychiatry 49: 447–450

    Article  PubMed  CAS  Google Scholar 

  • Roy-Byrne P, Post RM, Rubinow DR, Linnoila M, Savard D, Davis D (1983) CSF 5-HIAA and personal and family history of suicide in affectively ill patients: a negative study. Psychiatry Res 10: 263–274

    Article  PubMed  CAS  Google Scholar 

  • Sandyk R, Awerbuch GI (1993) Nocturnal melatonin secretion in suicidal patients with multiple sclerosis. Int J Neurosci 71: 173–182

    Article  PubMed  CAS  Google Scholar 

  • Santiago JM, Dalen JE (1944) Cholesterol and violent behavior. Arch Intern Med 154: 1317–1321

    Article  Google Scholar 

  • Sarrias MJ, Artigas F, Martinez E, Gelpi E (1989) Seasonal changes of plasma serotonin and related parameters: correlation with environmental measures. Biol Psychiatry 26: 695–706

    Article  PubMed  CAS  Google Scholar 

  • Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122: 509–522

    PubMed  CAS  Google Scholar 

  • Shaw DM, Camps FE, Eccleston EG (1967) 5-hydroxytryptamine in the hindbrain of depressive suicides. Br J Psychiatry 113: 1407–1411

    Google Scholar 

  • Sherif F, Marcusson J, Oreland L (1991) Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims. Eur Arch Psychiatry Clin Neurosci 241: 139–144

    Article  PubMed  CAS  Google Scholar 

  • Simonsson P, Träskman-Bendz L, Alling C, Oreland L, Regneil G, Ohman R (1991) Peripheral serotonergic markers in patients with suicidal behavior. Eur Neuropsychopharmacol 1 (4): 503–510

    Article  PubMed  CAS  Google Scholar 

  • Sneddon JM (1973) Blood platelets as a model for monoamine-containing neurones. Prog Neurobiol 1 (Part 2): 151–198

    Article  PubMed  CAS  Google Scholar 

  • Sparks DL, Little KY (1990) Altered pineal serotonin binding in some suicides. Psychiatry Res 32: 19–28

    Article  PubMed  CAS  Google Scholar 

  • Stahl SM (1985) Platelets as pharmacologic models for the receptors and biochemistry of monoaminergic neurones. In: Longenecker G (ed) The platelets. Physiology and pharmacology. Academic Press, New York, pp 307–340

    Google Scholar 

  • Stanley M (1984) Cholinergic receptor binding in the frontal cortex of suicide victims. Am J Psychiatry 141: 1432–1436

    PubMed  CAS  Google Scholar 

  • Stanley M, Mann J (1983) Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1: 214–216

    Article  PubMed  CAS  Google Scholar 

  • Stanley M, Virgilio J, Gershon S (1982) Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 216: 1337–1339

    Article  PubMed  CAS  Google Scholar 

  • Stanley M, Mann J, Gerhson S (1983) Alterations in pre- and postsynaptic serotonergic neurons in suicide victims. Psychopharmacol Bull 19: 684–687

    Google Scholar 

  • Stanley M, Träskman-Bendz L, Dorovini-Zis K (1985) Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 37 (Suppl 14): 1279–1286

    Article  PubMed  CAS  Google Scholar 

  • Stockmeier CA, Meitzer H Y (1991)ß-adrenergic receptor binding in frontal cortex of suicide victims. Biol Psychiatry 29: 183–191

    Google Scholar 

  • Stocks GM, Cheetham SC, Crompton MR, Katona CLE, Horton RW (1990) Benzodiazepine binding sites in amygdala and hippocampus of depressed suicide victims. J Affect Disord 18: 11–15

    Article  PubMed  CAS  Google Scholar 

  • Träskman-Bendz L, Ekman R, Regneil G, Ohman R (1992a) HPA-related CSF neuropeptides in suicide attempters. Eur Neuropsychopharmacol 2: 99–106

    Article  PubMed  Google Scholar 

  • Träskman-Bendz L, Alling C, Oreland L, Regnell G, Vinge E, Ohman R (1992b) Prediction of suicidal behavior from biologic tests. J Clin Psychopharmacol 12 (Suppl 2): 21S–26S

    PubMed  Google Scholar 

  • Vestergaard P, Stfrensen T, Hoppe E, Rafaelsen OJ, Yates CM, Nicolaou N (1978) Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders. Acta Psychiatr Scand 58: 88–96

    Article  PubMed  CAS  Google Scholar 

  • Virkkunen M, Nuutila A, Goodwin FK, Linnoila M (1987) Cerebrospinal fluid monoamine metabolite levels in male arsonists. Arch Gen Psychiatry 44: 241–247

    Article  PubMed  CAS  Google Scholar 

  • Wägner A, Äberg-Wistedt A, Asberg M, Ekqvist B, Martensson B, Montero D (1985) Lower 3H- imipramine binding in platelets from untreated depressed patients compared to healthy controls. Psychiatry Res 16: 131–139

    Article  PubMed  Google Scholar 

  • Wesemann W, Weiner N (1990) Circadian rhythm of serotonin binding in rat brain. Prog Neurobiol 35: 405 - 428

    Article  PubMed  CAS  Google Scholar 

  • Wetzler S, Kahn RS, Asnis GM, Korn M, van Praag HM (1991) Serotonin receptor sensitivity and aggression. Psychiatry Res 37: 271–279

    Article  PubMed  CAS  Google Scholar 

  • Wirz-Justice A (1988) Platelet research in psychiatry. Experientia 44: 145–152

    Article  PubMed  CAS  Google Scholar 

  • Wirz-Justice A, Richter R (1979) Seasonality in biochemical determinations: a source of variance and a clue to the temporal incidence of affective illness. Psychiatry Res 1: 53–60

    Article  PubMed  CAS  Google Scholar 

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Demling, J. (1996). Neurobiochemie suizidalen Verhaltens. In: Wolfersdorf, M., Kaschka, W.P. (eds) Suizidalität. Tropon-Symposium, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79855-9_4

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