Intracavernosal pharmacotherapy became popular between 1982 and 1983 when Virag  and Brindley  demonstrated that injection of papaverine, phentolamine, and phenoxybenzamine into the cavernosal body induces a penile erection. One year later Virag  proposed a therapeutic protocol based on “self-injection”. Patients suffering from penile erectile deficiency were examined, and those who showed a favorable response to intracavernous injections of papaverine were taught a technique that provides a “self-erection”. Zorgniotti and Lefleur  in 1985 proposed a combination of papaverine and phentolamine, and immediately thereafter the use of prostaglandin E1 (PGE1) became a common practice. This drug was preferred over the others because of its lower rate of side effects, prolonged erections, and priapism than that with papaverine or papaverine + phentolamine. Today the use of these drugs has become routine, and constitutes either singularly or in combination the first step of every therapeutic protocol that deals with erectile dysfunction.
KeywordsErectile Dysfunction Corpus Cavernosum Penile Erection Intracavernous Injection Penile Tissue
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