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Endothelin and Pulmonary Hypertension

  • Chapter
The Endothelium in Cardiovascular Disease

Abstract

Pulmonary hypertension (PH) can be a devastating hemodynamic disorder which carries with it grave negative prognostic connotations, regardless of the etiology of increased pulmonary vascular resistance. Like systemic hypertension, PH can be the end result of complex interactions between a variety influences, some of which can be readily identified, and others remain to be elucidated. The pulmonary bed represents a unique circulation that must receive the entire cardiac output and provide the geometric and physical conditions necessary for efficient gas exchange. One crucial aspect of pulmonary vascular physiology is the ability of the lung circulation to accommodate large variations in cardiac output and present minimal impedance to blood flow at all levels of its circulation (Voelkel and Weir 1989). In patients with PH, this function is compromised, usually because of a narrowing of pulmonary arteries, either due to an increase in vascular tone (i.e. vasoconstriction) or by remodelling, with hypertrophy of medial and intimal layers and muscularization of small arterioles (Voelkel and Weir 1989).

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Authors
  1. D. J. Stewart
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  2. D. Langleben
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Editors and Affiliations

  1. Abteilung Kardiologie, Inselspital, 3010, Bern, Switzerland

    Thomas F. Lüscher

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© 1995 Springer-Verlag Berlin Heidelberg

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Stewart, D.J., Langleben, D. (1995). Endothelin and Pulmonary Hypertension. In: Lüscher, T.F. (eds) The Endothelium in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79803-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-79803-0_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79805-4

  • Online ISBN: 978-3-642-79803-0

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