CD4 and Signal Transduction
CD4 is a 55–60 kDa monomeric glycoprotein expressed on approximately 60% of peripheral blood T lymphocytes (Reinherz et al. 1979; Terhorst et al. 1980). Originally identified as a phenotypic marker (Reinherz et al. 1979; Webb et al. 1979; Dialynas et al. 1983), a role for CD4 in the activation of T lymphocytes was indicated when anti-CD4 antibodies inhibited a variety of T lymphocyte effector functions in vitro (Krensky et al. 1982; Spits et al. 1982; Wilde et al. 1983; Rogozinski et al. 1984). It was later demonstrated that CD4 facilitates T lymphocyte function by binding to the nonpolymorphic region of the major histocompatibility (MHC) class II antigens expressed on the surface of antigen presenting cells (APCs) (Doyle and Strominger 1987; Sleckman et al. 1987; Gay et al. 1988; Cammarota et al. 1992; König et al. 1992). The interaction between CD4 and MHC class II molecules have proven to be critical for antigen responsiveness of CD4+T cells (Gay et al. 1987; Sleckman et al. 1987).
KeywordsTyrosine Phosphorylation Tyrosine Kinase Activity Cell Antigen Receptor Nucleotide Exchange Activity
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- Baldari CT, Macchia G, Telford JL (1992) lnterleukin-2 promoter activation in T cell expressing activated Ha-ras. J Biol Chem. 267: 4289–4291Google Scholar
- Collins TL, Uniyal S, Shin J, Strominger JL, Mittler RS, Burakoff SJ (1992) p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation. J Immunol 148: 2159–2162Google Scholar
- Dialynas DP, Quan ZS, Wall KA, Pierres A, Quintas J, Loken MR, Pierres M, Fitch FW (1993) Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol 131: 2445–2551Google Scholar
- Duplay P, Thome M, Hervé F, Acuto O (1994) p56lck interacts via its src homology domain with the ZAP-70 kinase. J Exp Med 179: 1163–1172Google Scholar
- Rayter S, Woodrow M, Lucas S, Cantrell D, Downward J (1992) p21ras mediates control of IL2 gene promoter function in T cell activation. EMBO J 11: 4549–4556Google Scholar
- Spits H, Borst J, Terhorst C, de Vries JE (1982) The role of T cell differentiation markers in antigen- specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens. J Immunol 129: 1563–1569PubMedGoogle Scholar
- Wilde DB, Marrack P, Kappler J, Dialynas DP, Fitch FW (1983) Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK15 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol 131: 2178–2183PubMedGoogle Scholar