Vitaminversorgung bei unreifen Frühgeborenen

  • O. Genzel-Boroviczény
  • N. Hrboticky
Conference paper

Zusammenfassung

Postnatal findet ein abrupter Übergang von einer relativ hypoxi-schen Umgebung in utero in eine vergleichsweise sauerstoffreiche Umwelt statt, ganz besonders bei beatmeten Frühgeborenen (FG), die zusätzlichen Sauerstoff benötigen. Antioxidanzien haben bei diesem Wechsel wahrscheinlich eine wichtige Funktion als Schutzfaktoren gegenüber diesem oxidativen Streß. Vitamin E wirkt aufgrund seiner Oxidierbarkeit als Antioxidans, d. h. es verhindert die spontane Oxidation stark ungesättigter Stoffe, vor allem die Peroxidbildung langkettiger Fettsäuren in den Membranlipiden.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Amorde-Spalding K, D’Harlingue AE, Phillips BL et al. (1992) Tocopherol levels in infants <1000 grams receiving M.V.I. Pediatric. Pediatrics 90:992–994PubMedGoogle Scholar
  2. Arrowsmith JB, Faich GA, Tomita DK et al. (1989) Morbidity and mortality among low birth weight infants exposed to an intravenous vitamin E product, E-Ferol. Pediatrics 83:244–249PubMedGoogle Scholar
  3. Baeckert PA, Greene HL, Fritz I et al. (1988) Vitamin concentrations in very low birth weight infants given vitamins intravenously in a lipid emulsion: Measurement of vitamins A, D and E and riboflavin. J Pediatr 113:1057–1066PubMedCrossRefGoogle Scholar
  4. Barak M, Herschkowitz S, Montag J (1986) Soft tissue calcification: A complication of vitamin E injection. Pediatrics 77:382–385PubMedGoogle Scholar
  5. Bell EF (1986) Prevention of bronchopulmonary dysplasia: vitamin E and other antioxydants. In: Farrel PM, Taussig LM (eds) BPD and related disorders. Ninth Ross Conference on Pediatric Research, 1986 WashingtonGoogle Scholar
  6. Chiswick M, Gladman G, Sinha S et al. (1991) Vitamin E supplementation and periventricular hemorrhage in the newborn. Am J Clin Nutr 53:370S–372SPubMedGoogle Scholar
  7. DeVito V, Reynolds JE, Benda GI, Carlson C (1986) Serum Vitamin E levels in very low birth weight infants receiving Vitamin E in parenteral nutrition solutions. JPEN 10:63–65CrossRefGoogle Scholar
  8. Dju MY, Mason KE, Filer LI (1952) Vitamin E (tocopherol) in human fetuses and placentae. Etudes Neonatales 1:49–62PubMedGoogle Scholar
  9. Drott P, Ewald U, Meurling S (1993) Plasma levels of fat-soluble vitamins A and E in neonates, after administration of two different vitamin solutions. Clin Nutr 12:96–102PubMedCrossRefGoogle Scholar
  10. Ehrenkranz RA, Bonta BW, Anlow RC, Warshaw JB (1978) Amoliration of bronchopulmonary dysplasia after vitamin E administration: a preliminary report. N Engl J Med 229:564–569CrossRefGoogle Scholar
  11. Finer NN, Grant G, Schindler RF et al. (1982) Effect of intramuscular vitamin E on frequency and severity of retrolental fibroplasia: a controlled trial. Lancet 1:1078–1091Google Scholar
  12. Finer NN, Peters KL, Hayek Z, Merkel CL (1984) Vitamin E and necrotizing enterocolitis. Pediatrics 73:387–393PubMedGoogle Scholar
  13. Fish WH, Cohen M, Franzek et al. (1990) Effect of intramuscular Vitamin E on mortality and intracranial hemorrhage in neonates of 1000 grams or less. Pediatrics 85:578–583PubMedGoogle Scholar
  14. Gillis J, Jones G, Pencharz P (1983) Delivery of vitamins A, D, and E in total parenteral nutrition solutions. JPEN 7:11–14CrossRefGoogle Scholar
  15. Greene HL, Courtney ME, Phillips BL et al. (1986) Evaluation of a pediatric multiple vitamin preparation for total parenteral nutrition II. Blood levels of vitamins A, D, and E. Pediatrics 77:539–547Google Scholar
  16. Greene HL, Phillips BL, Franck L et al. (1987) Persistently low blood retinol levels during and after parenteral feeding of very low birth weight infant: Examination of losses into intravenous administration sets and a method of prevention by addition to a lipid emulsion. Pediatrics 79:894–900PubMedGoogle Scholar
  17. Greene HL, Hambidge KM, Schanler R, Tsang RC (1988) Guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving total parenteral nutrition. Am J Clin Nutr 48:1324–1342PubMedGoogle Scholar
  18. Gross SJ (1993) Vitamin E. In: Tsang RC, Lucas A, Uauy R, Zlotkin S (eds) Nutritional needs of the preterm infant. Williams & Wilkins, Baltimore London, pp 101–109Google Scholar
  19. Gross SJ, Gabriel E (1985) Vitamin E status in preterm infants fed human milk or infant formula. J Pediatr 101:635–639Google Scholar
  20. Gutcher GR, Lax AA, Farrell PM (1984) Vitamin A losses to plastic intravenous infusion devices and an improved method of delivery. Am J Clin Nutr 40:8–13PubMedGoogle Scholar
  21. Hittner H, Godio LB, Rudolph AJ et al. (1981) Retrolental fibroplasia: Efficacy of vitamin E in a double-blind clinical study of preterm infants. N Engl J Med 305:1365–1375PubMedCrossRefGoogle Scholar
  22. Johnson L, Bowen FW, Abbasi S et al. (1985) Relationship of prolonged pharmacologic serum levels of Vitamin E to incidence of sepsis and necrotizing enterocolitis in infants with birth weight 1500 grams or less. Pediatrics 75:619–638PubMedGoogle Scholar
  23. Johnson L, Quinn GE, Abbasi S et al. (1989) Effect of sustained pharmacological vitamin E levels on incidence and severity of retinopathy of prematurity: a controlled clinical trial. J Pediatr 114:827–838PubMedCrossRefGoogle Scholar
  24. Karp WB, Robertson AF (1986) Vitamin E in neonatology. Adv Pediatr 33:127–147PubMedGoogle Scholar
  25. Kretzer FL, Hittner HM (1988) Retinopathy of prematurity: clinical implications of retinal development. Arch Dis Child 63:1151–1167PubMedCrossRefGoogle Scholar
  26. Lorch V, Murphy DM, Hoersten L et al. (1985) Unusual syndrome among premature infants: association with a new intravenous vitamin E product. Pediatrics 75:598–602PubMedGoogle Scholar
  27. MacDonald MG, Fletcher AB, Johnson EL et al. (1987) The potential toxicity to neonates of multivitamin preparations used in parenteral nutrition. JPEN 11:169–171CrossRefGoogle Scholar
  28. McClung HJ, Backes C, Lavin A, Kerzner B (1980) Prospective evaluation of vitamin E therapy in premature infants with hyaline membrane disease. Pediatr Res 14:604. AbstractGoogle Scholar
  29. Phelps DL, Rosenbaum AL, Isenberg SJ et al. (1987) Tocopherol efficacy and safety for preventing retinopathy of prematurity: a randomized controlled double masked trial. Pediatrics 79:489–500PubMedGoogle Scholar
  30. Phillips B, Franck LS, Greene HL (1987) Vitamin E levels in premature infants during and after intravenous multivitamin supplementation. Pediatrics 80:680–683PubMedGoogle Scholar
  31. Shenai JP, Chytil F, Stahlmann MT (1985) Liver vitamin A reserves of very low birth weight neonates. Pediatr Res 119:892–893CrossRefGoogle Scholar
  32. Sinha S, Toner N, Davies et al. (1987) Vitamin E supplementation reduces frequency of periventricular haemorrhage in very preterm babies. Lancet 466–470Google Scholar
  33. Solomon LA, Brown RE, Paquet A (1986) Polysorbate 80 and E-Ferol toxicity. Pediatrics 77:593–596Google Scholar
  34. Speer ME, Blifeld C, Rudolph A et al. (1984) Intraventricular hemorrhage and vitamin E in low-birth-weight-infant: evidence of efficacy of early intramuscular vitamin E administration. Pediatrics 74:1107–1112PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • O. Genzel-Boroviczény
  • N. Hrboticky

There are no affiliations available

Personalised recommendations