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The Splanchnic Microcirculation: Cytokines and Cell Adhesion Molecules

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The Splanchnic Circulation

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 23))

Abstract

This chapter focuses on the function of the intestinal microcirculation in the inflammatory response, which is characterized by leukocyte infiltration, increased microvascular permeability, edema, and frequently also tissue damage. Leukocyte traffic in inflammation is regulated by chemoattractants and by specific adhesion molecules, whose expression on endothelial cells is controlled by cytokines. Regulation of cell adhesion at the blood-endothelial interface has received considerable attention in the past decade, which has led to the development of a conceptual framework for leukocyte movement in inflammatory and immune responses. The recent availability of specific antibodies, peptides, carbohydrates, and gene-deficient and transgenic rodents is critical for further elucidating the mechanisms of intestinal inflammation.

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  1. K. Ley
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Editors and Affiliations

  1. Dept. of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 604 Scaife Hall, 15261, Pittsburgh, PA, USA

    Michael R. Pinsky

  2. Clinical Pharmacology and Critical Care Medicine, Cochin Port-Royal University Hospital, 27 rue du Faubourg St. Jaques, F-75679, Paris, France

    Jean-Francois Dhainaut

  3. Servei des Medicina Intensiva Parc Tauli, Consorci Hospitalari Parc Tauli, E-08208, Sabadell, Spain

    Antonio Artigas

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Ley, K. (1995). The Splanchnic Microcirculation: Cytokines and Cell Adhesion Molecules. In: Pinsky, M.R., Dhainaut, JF., Artigas, A. (eds) The Splanchnic Circulation. Update in Intensive Care and Emergency Medicine, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79715-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-79715-6_3

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