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Clinical and Molecular Advances in Acute Promyelocytic Leukaemia

  • Conference paper
Retinoids in Oncology

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

  • 34 Accesses

Abstract

Acute promyelocytic leukaemia (APL) comprises approximately 10% of the acute myeloblastic leukaemias in adults [1,2]. The disease was first recognised as a distinctive clinical entity in the 1950s [3] and it typically presents with a severe bleeding diathesis that is exacerbated by chemotherapy [4–7]. This feature has led to a relatively high rate of early mortality, ranging from 8% to 47% in recent series [4–9], primarily as a consequence of intracranial haemorrhage [9–11]. In this chapter, we review the latest information regarding the molecular genetics and current methods of therapy of this disease.

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Authors and Affiliations

  1. Hôpital St. Louis, Institut Universitaire d’Hématologie, 1, Avenue Claude Vellefaux, 75010, Paris, France

    Hugues de Thé & Laurent Degos

  2. Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA

    Raymond P. Warrell Jr

Authors
  1. Hugues de Thé
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  2. Laurent Degos
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  3. Raymond P. Warrell Jr
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Editors and Affiliations

  1. Hôpital St. Louis, Institut Universitaire d’Hématologie, 1, Avenue Claude Vellefaux, 75010, Paris, France

    Laurent Degos

  2. Investigational Drug Branch, Division of Cancer Treatment, National Cancer Institute, 6130 Executive Boulevard, 20892, Rockville, MD, USA

    David R. Parkinson M.D.

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© 1995 Springer-verlag Berlin heidelberg

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de Thé, H., Degos, L., Warrell, R.P. (1995). Clinical and Molecular Advances in Acute Promyelocytic Leukaemia. In: Degos, L., Parkinson, D.R. (eds) Retinoids in Oncology. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79706-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-79706-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79708-8

  • Online ISBN: 978-3-642-79706-4

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