Abstract
The ability to recognize self and non-self exists in all animal species. Unicellular animals, such as protozoans, which often engulf living microorganisms, must discriminate between them and nutrition proteins, to prevent damage to their own proteins during digestive processes. The mechanism of discrimination at this level is unknown. One can assume that the specificity is based on substrate specificity of the proteolytic enzymes (Valembois et al. 1973; Ratcliffe et al. 1984, 1991; Tučková etal. 1986a). The main defense mechanisms in multicellular invertebrates are certainly represented by innate factors. Microorganisms that break the outer protective barrier and invade the host are mainly eliminated by phagocytosis which can be potentiated by humoral factors. Moreover, body fluids (e.g. hemolymph, celomic fluid) contain antibacterial molecules that probably prevent the multiplication of these bacteria.
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Tučková, L., Bilej, M. (1996). Mechanisms of Antigen Processing in Invertebrates: Are There Receptors?. In: Cooper, E.L. (eds) Invertebrate Immune Responses. Advances in Comparative and Environmental Physiology, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79693-7_3
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